(data stored in ACNUC8465 zone)

HOGENOM: CAEELX_PE2329

ID   CAEELX_PE2329                        STANDARD;      PRT;   363 AA.
AC   CAEELX_PE2329; Q20347; O01707;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=MAP kinase kinase mkk-4; EC=2.7.12 2; (CAEELX.PE2329).
GN   Name=mkk-4; ORFNames=F42G10.2;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELX.PE2329.
CC       Caenorhabditis elegans chromosome X WS210  sequence 1..17718854
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MKK4_CAEEL
CC   -!- FUNCTION: Activity is required in presynaptic neurons, in a dose-
CC       dependent manner, for normal presynaptic development and
CC       morphology.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;F42G10.2;F42G10.2;F42G10.2.
DR   EMBL; Z48230; - ;
DR   EMBL; Z95122; - ;
DR   UniProtKB/Swiss-Prot; Q20347; O01707; -.
DR   EMBL; Z95122; CAB08355.1; -; Genomic_DNA.
DR   EMBL; Z48230; CAB08355.1; JOINED; Genomic_DNA.
DR   EMBL; Z48230; CAA88264.1; -; Genomic_DNA.
DR   EMBL; Z95122; CAA88264.1; JOINED; Genomic_DNA.
DR   PIR; T22107; T22107.
DR   RefSeq; NP_509682.1; NM_077281.3.
DR   UniGene; Cel.1019; -.
DR   ProteinModelPortal; Q20347; -.
DR   SMR; Q20347; 59-339.
DR   DIP; DIP-25523N; -.
DR   IntAct; Q20347; 3.
DR   MINT; MINT-1043930; -.
DR   STRING; Q20347; -.
DR   PRIDE; Q20347; -.
DR   EnsemblMetazoa; F42G10.2; F42G10.2; F42G10.2.
DR   GeneID; 185682; -.
DR   KEGG; cel:F42G10.2; -.
DR   NMPDR; fig|6239.3.peg.24349; -.
DR   UCSC; F42G10.2; c. elegans.
DR   CTD; 185682; -.
DR   WormBase; F42G10.2; CE10328; WBGene00003368; mkk-4.
DR   eggNOG; meNOG06028; -.
DR   GeneTree; EMGT00050000000989; -.
DR   InParanoid; Q20347; -.
DR   OMA; AIFSEGD; -.
DR   PhylomeDB; Q20347; -.
DR   NextBio; 929126; -.
DR   ArrayExpress; Q20347; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:WormBase.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; IGI:WormBase.
DR   GO; GO:0050807; P:regulation of synapse organization; IMP:WormBase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; CAEELX.PE2329; -.
KW   F42G10.21149200367fold_1320000031; F42G10.2.211.20.62fold_1320000031;
KW   Z48230; Z95122;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   363 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVQEDDENLR NSMSLRPTSL STRPTSLSVN GNEKTLPEES VLRSLSTGTL KYPDDEHLYT
     FSSANLQDLG AIGNGNFGTV YKMRHKETGK LIAVKRIRCN NIGHREQIRL LREHDTIVKS
     EKGPNIVKFY GAIFSEGDCW ICMELMDISM DLLYKRVYMV KNSRLNENVV GHITVCTVDA
     LDYLKKELKI IHRDVKPSNI LVDGTGAVKL CDFGICGQLE ESFAKTHDAG CQPYLAPERI
     TSSDKYDVRS DVWSLGITLY EIATGKFPYQ EWNSLFDQIA TVVSGDPPIL HPDSDDFHYS
     LPLVKFINTC LTKDRRHRPK YDTLKSFDFY RIYAVAGPEI EEAKRILGVE AIDTRNHPVD
     HRG
//

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