(data stored in ACNUC5448 zone)

HOGENOM: CAEELX_PE457

ID   CAEELX_PE457                         STANDARD;      PRT;   2098 AA.
AC   CAEELX_PE457; P91443;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Unconventional myosin heavy chain 6; (CAEELX.PE457).
GN   Name=hum-6; ORFNames=T10H10.1;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELX.PE457.
CC       Caenorhabditis elegans chromosome X WS210  sequence 1..17718854
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:HUM6_CAEEL
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase
CC       activity. Unconventional myosins serve in intracellular movements.
CC       Their highly divergent tails are presumed to bind to membranous
CC       compartments, which would be moved relative to actin filaments (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with unc-98.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Contains 2 FERM domains.
CC   -!- SIMILARITY: Contains 3 IQ domains.
CC   -!- SIMILARITY: Contains 1 myosin head-like domain.
CC   -!- SIMILARITY: Contains 2 MyTH4 domains.
CC   -!- SIMILARITY: Contains 1 Ras-associating domain.
CC   -!- GENE_FAMILY: HOG000007836 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;T10H10.1;T10H10.1;T10H10.1.
DR   EMBL; U80848; - ;
DR   UniProtKB/Swiss-Prot; P91443; -.
DR   EMBL; U80848; AAB37988.1; -; Genomic_DNA.
DR   PIR; T25888; T25888.
DR   RefSeq; NP_508420.1; NM_076019.2.
DR   UniGene; Cel.767; -.
DR   HSSP; P08799; 1MND.
DR   ProteinModelPortal; P91443; -.
DR   SMR; P91443; 3-760, 905-1561, 1583-2083.
DR   IntAct; P91443; 1.
DR   MINT; MINT-227760; -.
DR   STRING; P91443; -.
DR   PRIDE; P91443; -.
DR   EnsemblMetazoa; T10H10.1; T10H10.1; T10H10.1.
DR   GeneID; 180539; -.
DR   KEGG; cel:T10H10.1; -.
DR   NMPDR; fig|6239.3.peg.22643; -.
DR   UCSC; T10H10.1; c. elegans.
DR   CTD; 180539; -.
DR   WormBase; T10H10.1; CE13575; WBGene00002039; hum-6.
DR   eggNOG; meNOG05224; -.
DR   GeneTree; EMGT00050000000756; -.
DR   InParanoid; P91443; -.
DR   OMA; EMSAKKA; -.
DR   PhylomeDB; P91443; -.
DR   NextBio; 909796; -.
DR   ArrayExpress; P91443; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031476; C:myosin VI complex; TAS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:motor activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR011993; PH_type.
DR   Gene3D; G3DSA:1.20.80.10; ACBP; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 2.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00295; B41; 2.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00139; MyTH4; 2.
DR   SUPFAM; SSF47031; FERM_3-hlx; 2.
DR   PROSITE; PS00660; FERM_1; FALSE_NEG.
DR   PROSITE; PS00661; FERM_2; FALSE_NEG.
DR   PROSITE; PS50057; FERM_3; 2.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51016; MYTH4; 2.
DR   PROSITE; PS50200; RA; FALSE_NEG.
DR   HOGENOMDNA; CAEELX.PE457; -.
KW   T10H10.1.149200367fold_1320000031; T10H10.1.222.20.62fold_1320000031;
KW   U80848;
KW   Actin-binding; ATP-binding; Complete proteome; Cytoplasm;
KW   Motor protein; Myosin; Nucleotide-binding; Reference proteome; Repeat.
SQ   SEQUENCE   2098 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVLVSKGDFI WIEPGKTEGS IPIGARVIDQ DHGRLKVIDD LGNEQWLSAD RRVRLMHPTS
     VQGVEDMCQL GDFHESAILR NLFIRYREKL IYAYTGSILI AVNPYMDIAI YTADEIRMYK
     RKRIGELPPH IFAIADNAYT NMRREKKNQS VIISGESGAG KTESTKLVLQ FLATISGQHS
     WIEQQVLEAN PVLEAFGNAK TIRNDNSSRF GKYIDVHFNE SGSIEGAKIE QYLLEKSRIV
     TQSENERNYH IFYCLLAGLS REEKSELELG TAADYYYLIQ GKTLTAEGRD DAADLAEIRS
     AMRVLMINEQ EIGSIFKLLA SLLHIGNIRF RQNTNDNMES VDVADPSTLV RIAKLLQLHE
     QNLLDAITTK SLVTREERVI SRLNGQQAVD ARDALAKAIY GKLFIHIVRR VNDAIYKPSQ
     SRRTSIGILD IFGFENFESN SFEQLCINFA NETLQQFFVH HVFKMEQKEY DEEHINWRHI
     KFVDNQATVD LIAQRPLNIL SLIDEESIFP KGTDKTMLLK LHSTHGRNEL YLQPKSELQR
     AFGVTHFAGN VFYNTRGFLE KNRDSFSADL SVLISSSKMP FLARLFDDIE YDTSSRKKVT
     VGNQFRRSLE QLMSQLTQTH PFFIRCIKPN EMKRALVMDR DLVLRQLRYS GMMETIKIRR
     SGYPIRHDYY PFVFRYRVLV SSIQGPVNRI DLHDAAKKIC HMILGTNADY QLGKTKVFLK
     DKHDLVLEQE YYRILKDKAI VIQKNVRRWL VRKDFEKQRQ AAVTIQTAWR GFDQRKRYRQ
     IISGFSRLQA VLRSRQLVSH YQTLRKTIIQ FQAVCRGSLV RRQVGEKRKR GEKAPLTEVS
     STASVISDSH EELVGHLFDF LPSDGKDSGN ENDSADSSRR GSYSRLHTSP VMPPANIPRV
     DSYVDEDLSK YQFGKYAATF FQAQATATHV KKPLKTALLT HTEPSAQLAA LTAWTTILRF
     MGDLADVKPG STNGSEVYDK TPVMIKLYAT LGKKFSAHDL EEAMLSSEYG GAKTLKKGMG
     RKLISMTLKR KGKINGSDTS SISSDSVYSS FNAMLENKPM TSLDKLHYII GLGILREDLR
     DEIYCQLCKQ LSNNPSKLSA ARGWILLSLC VGCFAPSERF IKYLFCFIRE RGPAGTGYSK
     YIEDRLRRTQ VNGTRHQPPS YVELQANKSQ KPVVLAVTFM DGSVKTLCAD SATTAAELCK
     QLAEKVGLTN SFGFSLYIAL FDKVSSLGSG TDHVMDAISQ CEQYAKEQGR QERNAPWRLF
     FRKEIFSPWH DPRDDPVSTN LIYQQVIRGI KYGEYRCDKD EELAAICAQQ YYIDEGTMDV
     NKLENNLPSY LPDFEMSGKE MALEKWTQTI MHQYRKKFTG RLPSQIEVKE NVVSVAKTKW
     PLLFSRFYEA LKFAGPPLPK NEVIIAVNWT GVYVVDDREH VMLEFSFPEI STAYYGKGKR
     STTDTCTVRT VVGDEYTFQS PNADDITNLI VMFLEGLKKR SRYLVAIKSQ KGDEKNNFLE
     FEKGDLLILV NEFTGNTLLT ESVVKGENSR TCLFGLIRAE NVYVLPTLVK PSKNTLQIFP
     KDMDLSLDLF NNNKQVTVVD YNAEPYTLEN FAEDNFNSQV KRVGSQISLM TLRKKESQIE
     CWRFSREHID QPLLKKLNGR EDACRGAIEI FAAIMKYMGD EPSKRSRLGT HLTDHIFKLP
     ISMEALRDEL YCQLVKQLTL NPSIMSEERG WELLWMATGL FAPSAALAKE ISHFLKSRPH
     PIALDCQNRM QKLAKGGSRK YPPHLVEVEA IQHKTTQIFH KVFFPDNTDE AIEVDSATRA
     RDFCHKIGYR LGLKSSDGFS LFVKIKDKVL AVPESEFFFD YVRSLSDWVH TNHATQKDAT
     MIPINYQVYF MRKLWYNFVA GADPQADIIF HYHQESQKYL LGYHKTTKND VIELAALILR
     SMTKDGKNAP LAQIPQLLDE IIPKDSLKMY SASEWRKTIS NAYARIEHLK SDQAKIEFLN
     YICRWPTFGS AFFPVSQYSD LNLPDRLLLA INQTGVNIYH LDTKNLLVQY PFNVICNWTS
     GNTYFNMTVG NMLKGNEGKK LLLDTTVGYK MDDLLTSYIS LLISNQNNHP SKTREVAL
//

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