(data stored in SCRATCH3701 zone)

HOGENOM6: CAMJ2_1_PE950

ID   CAMJ2_1_PE950                        STANDARD;      PRT;   863 AA.
AC   CAMJ2_1_PE950; Q03470; Q0P9M5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (CAMJ2_1.PE950).
GN   Name=gyrA; OrderedLocusNames=Cj1027c;
OS   CAMPYLOBACTER JEJUNI SUBSP. JEJUNI NCTC 11168.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAMJ2_1.PE950.
CC       Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete geno
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_CAMJE
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q03470; Q0P9M5; -.
DR   EMBL; L04566; AAA23028.1; -; Genomic_DNA.
DR   EMBL; AL111168; CAL35145.1; -; Genomic_DNA.
DR   PIR; A48902; A48902.
DR   RefSeq; YP_002344422.1; NC_002163.1.
DR   ProteinModelPortal; Q03470; -.
DR   SMR; Q03470; 33-488.
DR   IntAct; Q03470; 23.
DR   GeneID; 905319; -.
DR   GenomeReviews; AL111168_GR; Cj1027c.
DR   KEGG; cje:Cj1027c; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; CJEJ192222:CJ1027C-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; CAMJ2_1.PE950; -.
DR   PRODOM; CAMJ2_1_PE950.
DR   SWISS-2DPAGE; CAMJ2_1_PE950.
KW   Antibiotic resistance; ATP-binding; Complete proteome; Cytoplasm;
KW   DNA-binding; Isomerase; Nucleotide-binding; Reference proteome;
KW   Topoisomerase.
SQ   SEQUENCE   863 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MENIFSKDSD IELVDIENSI KSSYLDYSMS VIIGRALPDA RDGLKPVHRR ILYAMQNDEA
     KSRTDFVKSA RIVGAVIGRY HPHGDTAVYD ALVRMAQDFS MRYPSITGQG NFGSIDGDSA
     AAMRYTEAKM SKLSHELLKD IDKDTVDFVP NYDGSESEPD VLPSRVPNLL LNGSSGIAVG
     MATNIPPHSL NELIDGLLYL LDNKDASLEE IMQFIKGPDF PTGGIIYGKK GIIEAYRTGR
     GRVKVRAKTH IEKKTNKDVI VIDELPYQTN KARLIEQIAE LVKERQIEGI SEVRDESNKE
     GIRVVIELKR EAMSEIVLNN LFKSTTMEST FGVIMLAIHN KEPKIFSLLE LLNLFLTHRK
     TVIIRRTIFE LQKARARAHI LEGLKIALDN IDEVIALIKN SSDNNTARDS LVAKFGLSEL
     QANAILDMKL GRLTGLEREK IENELAELMK EIARLEEILK SETLLENLIR DELKEIRSKF
     DVPRITQIED DYDDIDIEDL IPNENMVVTI THRGYIKRVP SKQYEKQKRG GKGKLAVTTY
     DDDFIESFFT ANTHDTLMFV TDRGQLYWLK VYKIPEGSRT AKGKAVVNLI NLQAEEKIMA
     IIPTTDFDES KSLCFFTKNG IVKRTNLSEY QNIRSVGVRA INLDENDELV TAIIVQRDED
     EIFATGGEEN LENQEIENLD DENLENEESV STQGKMLFAV TKKGMCIKFP LAKVREIGRV
     SRGVTAIKFK EKNDELVGAV VIENDEQEIL SISAKGIGKR TNAGEYRLQS RGGKGVICMK
     LTEKTKDLIS VVIVDETMDL MALTSSGKMI RVDMQSIRKA GRNTSGVIVV NVENDEVVSI
     AKCPKEENDE DELSDENFGL DLQ
//

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