(data stored in ACNUC15468 zone)

HOGENOM: CANFA16_10_PE14

ID   CANFA16_10_PE14                      STANDARD;      PRT;   984 AA.
AC   CANFA16_10_PE14; Q9MZT1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein 1; Short=ClC-1;AltName:
DE   Full=Chloride channel protein, skeletal muscle; (CANFA16_10.PE14).
GN   Name=CLCN1;
OS   CANIS LUPUS FAMILIARIS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CANFA16_10.PE14.
CC       Canis familiaris chromosome 16 BROADD2 partial sequence 8971290..996653
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN1_CANFA
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- DISEASE: Note=Defects in CLCN1 are the cause of autosomal
CC       recessive myotonia congenita (MCR). MCR is a disorder of
CC       sarcolemmal excitation leading to delayed relaxation of skeletal
CC       muscle following contractions. The disease has been identified in
CC       the miniature Schnauzer breed.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The absence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as channels (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-1/CLCN1 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Canis_familiaris;ENSCAFG00000003619;ENSCAFT00000020333;ENSCAFP00000018866.
DR   EMBL; AF162445; - ;
DR   UniProtKB/Swiss-Prot; Q9MZT1; -.
DR   EMBL; AF162445; AAF82606.1; -; mRNA.
DR   RefSeq; NP_001003124.1; NM_001003124.1.
DR   RefSeq; XP_855566.1; XM_850473.1.
DR   UniGene; Cfa.3588; -.
DR   ProteinModelPortal; Q9MZT1; -.
DR   SMR; Q9MZT1; 773-867.
DR   GeneID; 403723; -.
DR   KEGG; cfa:403723; -.
DR   CTD; 1180; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; Q9MZT1; -.
DR   OrthoDB; EOG4VT5WG; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002243; Cl_channel-1.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 1.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01112; CLCHANNEL1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; CANFA16_10.PE14; -.
KW   ENSCAFG00000003619fold_1320000031; ENSCAFP00000018866fold_1320000031;
KW   O46609_CANFA; AF162445;
KW   CBS domain; Chloride; Chloride channel; Complete proteome;
KW   Disease mutation; Ion transport; Ionic channel; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
SQ   SEQUENCE   984 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQPSQSLRRG GEQSWWGSAP QYQYMPFEHC TSYGLPSENG ALQHRLHRDA GLRANTRPTQ
     IYGHYKQQFS DKEQDTGMSK KMGSSESMDS KDEDHYSKCQ GCVRRLGHVV RRKLGEDWIF
     LVLLGLLMAL VSWSMDYVSA KSLQAYKWSY YQMQPNLPLQ YLVWVTFPLT LILFSAVFCH
     LISPQAVGSG IPEMKTILRG VILKEYLTLK AFVAKVVALT AGLGSGIPVG KEGPFVHIAS
     ICAAVLSKFM SMFCGVYEQP YYYTDMLTVG CAVGVGCCFG TPLGGVLFSI EVTSTYFAVR
     NYWRGFFAAT FSAFVFRVLA VWNKDAVTIT ALFRTNFRMD FPFDLQELPA FAIIGICCGF
     LGAVFVYLHR QVMLGVRKHK ALSQFLAKHR LLYPGIVTFI IASFTFPPGI GQFMAGELMP
     REAISTLFDN NTWVKHVGDP ESLGRSAVWI HPRVNVIIII FLFFIMKFWM SIVATTMPIP
     CGGFMPVFVL GAAFGRLVGE IMAMLFPDGI LFDDIIYKIL PGGYAVIGAA ALTGAVSHTV
     STAVICFELT GQIAHILPMM VAVILANMVA QSLQPSLYDS IIQVKKLPYL PDLGWNQLSK
     FTIFVEDIMV RDVKFVSATC TYGELRTLLQ TTTVKTLPLV DSKDSMILLG SVERSELQSL
     LQRHLGPERR LRVAQDMARK LSELPYDGKG HQGISPEGRR ESFAFVDEDE DEDLSGKPEV
     TKQTMVPLPP LPPPHPLPSA PLSSEESNGP LPSHKQQPEA PEPADQRPSV FRSLLRCLLG
     RPRPTKKKTT QESMDLVDNM SPEEIEAWEQ EQLSQPVCFD YCCIDQSPFQ LVEQTSLHKT
     HTLFSLLGLH LAYVTSMGKL RGVLALEELQ KAIEGHTKSG VQLRPPLASF RSTTSTRKNP
     GGPPPPTEAW SLPEDGTGAP ASPEPPAPSP SPAPLLSEAP AKVEGELEEL ELGESPGLEE
     ELADILQGPS LRSTDEEDED ELIL
//

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