(data stored in ACNUC8465 zone)

HOGENOM: CANFA2_82_PE2

ID   CANFA2_82_PE2                        STANDARD;      PRT;   205 AA.
AC   CANFA2_82_PE2; P60952; P21181; P25763;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Cell division control protein 42 homolog;AltName: Full=G25K
DE   GTP-binding protein;Flags: Precursor; (CANFA2_82.PE2).
GN   Name=CDC42;
OS   CANIS LUPUS FAMILIARIS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CANFA2_82.PE2.
CC       Canis familiaris chromosome 2 BROADD2 partial sequence 80044001..808906
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CDC42_CANFA
CC   -!- FUNCTION: Plasma membrane-associated small GTPase which cycles
CC       between an active GTP-bound and an inactive GDP-bound state. In
CC       active state binds to a variety of effector proteins to regulate
CC       cellular responses. Involved in epithelial cell polarization
CC       processes. Plays a role in the extension and maintenance of the
CC       formation of thin, actin-rich surface projections called filopodia
CC       (By similarity).
CC   -!- ENZYME REGULATION: Regulated by guanine nucleotide exchange
CC       factors (GEFs) which promote the exchange of bound GDP for free
CC       GTP, GTPase activating proteins (GAPs) which increase the GTP
CC       hydrolysis activity, and GDP dissociation inhibitors which inhibit
CC       the dissociation of the nucleotide from the GTPase (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4,
CC       CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-
CC       dependent manner). Interacts with activated CSPG4 and with BAIAP2.
CC       Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate
CC       it by exchanging GDP for GTP. Interacts with NET1 and
CC       ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and
CC       PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1 (By
CC       similarity). Interacts with USP6 (By similarity). Interacts with
CC       NEK6 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential). Cytoplasm, cytoskeleton, centrosome (By
CC       similarity). Note=Co-localizes with NEK6 in the centrosome (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Placental;
CC         IsoId=P60952-2, P21181-4;
CC         Sequence=Displayed;
CC       Name=2; Synonyms=Brain;
CC         IsoId=P60952-1, P21181-1;
CC         Sequence=VSP_010078, VSP_010079;
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       CDC42 subfamily.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Canis_familiaris;ENSCAFG00000014707;ENSCAFT00000023351;ENSCAFP00000021684.
DR   EMBL; Z49944; - ;
DR   UniProtKB/Swiss-Prot; P60952; P21181; P25763; -.
DR   EMBL; Z49944; CAA90215.1; -; mRNA.
DR   PIR; S57563; S57563.
DR   RefSeq; NP_001003254.1; NM_001003254.1.
DR   RefSeq; XP_855582.1; XM_850489.1.
DR   UniGene; Cfa.39956; -.
DR   ProteinModelPortal; P60952; -.
DR   SMR; P60952; 1-191.
DR   STRING; P60952; -.
DR   PRIDE; P60952; -.
DR   Ensembl; ENSCAFT00000023350; ENSCAFP00000021683; ENSCAFG00000014707.
DR   GeneID; 403934; -.
DR   KEGG; cfa:403934; -.
DR   CTD; 998; -.
DR   eggNOG; maNOG09480; -.
DR   GeneTree; ENSGT00560000076570; -.
DR   InParanoid; P60952; -.
DR   OMA; EITHHCQ; -.
DR   OrthoDB; EOG4R23VV; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; CANFA2_82.PE2; -.
KW   ENSCAFG00000014707fold_1320000031; ENSCAFP00000021684fold_1320000031;
KW   Z49944;
KW   Acetylation; Alternative splicing; Cell membrane; Complete proteome;
KW   Cytoplasm; Cytoskeleton; Differentiation; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Neurogenesis; Nucleotide-binding; Prenylation;
KW   Reference proteome.
SQ   SEQUENCE   205 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     SVFGLTMQTI KCVVVGDGAV GKTCLLISYT TNKFPSEYVP TVFDNYAVTV MIGGEPYTLG
     LFDTAGQEDY DRLRPLSYPQ TDVFLVCFSV VSPSSFENVK EKWVPEITHH CPKTPFLLVG
     TQIDLRDDPS TIEKLAKNKQ KPITPETAEK LARDLKAVKY VECSALTQRG LKNVFDEAIL
     AALEPPETQP KRNCGSRSLH PCLRL
//

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