(data stored in ACNUC7421 zone)

HOGENOM: CAUCN_1_PE1008

ID   CAUCN_1_PE1008                       STANDARD;      PRT;   513 AA.
AC   CAUCN_1_PE1008; B8H2S1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Histidine ammonia-lyase; Short=Histidase; EC=4.3.1 3;
DE   (CAUCN_1.PE1008).
GN   Name=hutH; OrderedLocusNames=CCNA_01010;
OS   CAULOBACTER CRESCENTUS NA1000.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAUCN_1.PE1008.
CC       Caulobacter crescentus NA1000 chromosome, complete genome.
CC       (1809 nt) ;
CC   -!- ANNOTATIONS ORIGIN:HUTH_CAUCN
CC   -!- CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO),
CC       which is formed autocatalytically by cyclization and dehydration
CC       of residues Ala-Ser-Gly (By similarity).
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
CC   -!- GENE_FAMILY: HOG000237620 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B8H2S1; -.
DR   EMBL; CP001340; ACL94475.1; -; Genomic_DNA.
DR   RefSeq; YP_002516383.1; NC_011916.1.
DR   STRING; B8H2S1; -.
DR   GeneID; 7329758; -.
DR   GenomeReviews; CP001340_GR; CCNA_01010.
DR   KEGG; ccs:CCNA_01010; -.
DR   OMA; NAPVYGI; -.
DR   ProtClustDB; PRK09367; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006548; P:histidine catabolic process; IEA:InterPro.
DR   HAMAP; MF_00229; His_ammonia-lyase; 1; -.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   InterPro; IPR024083; L-Aspartase-like_N.
DR   InterPro; IPR001106; Phe/His_NH3-lyase.
DR   InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR   Gene3D; G3DSA:1.10.275.10; G3DSA:1.10.275.10; 1.
DR   Pfam; PF00221; PAL; 1.
DR   SUPFAM; SSF48557; L-Aspartase-like; 1.
DR   TIGRFAMs; TIGR01225; HutH; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
DR   HOGENOMDNA; CAUCN_1.PE1008; -.
KW   histidine ammonia-lyase;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Lyase.
SQ   SEQUENCE   513 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MERPVTELVL NPGAVPLAEW KAIYRGASAR LAESAWPVIA ESAAAVQRIL AKGEPVYGIN
     TGFGKLASVR IGDADLETLQ RNIVLSHAAG VGEPSPVPVI RLMMALKLAS LAQGASGVRV
     ETVRMLEEML VEGLTPVVPC QGSVGASGDL APLSHMAATM IGVGEIFVGG QRLPAAQALA
     QAGLEPLTLG PKEGLALLNG TQFSTANALA GLFEAERLFQ SALVTGALST EAAKGSDTPF
     DPRIHTLRRH VGQIETAAAL RALMSASEIR ASHLKEDERV QDPYCLRCQP QVMGAALDIL
     RQAATTLATE ANCVSDNPLI FPEADEALSG GNFHAEPVAF AADMIALAVC EIGSIAERRI
     AMLVDPALSG LPAFLTPKPG LNSGFMIPQV TAAALVSENK QRAYPASVDS IPTSANQEDH
     VSMAAHGARR LLAMVENADA VLGIELLAAA QGCDFHAPLR SSAALEAVRA LTRSKVPHLS
     DDRHFHPDME AANTLVRSGA VIAAVGALPG VTA
//

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