(data stored in ACNUC15468 zone)

HOGENOM: CAVPO7_51_PE12

ID   CAVPO7_51_PE12                       STANDARD;      PRT;   877 AA.
AC   CAVPO7_51_PE12; Q9WU45; Q9R247; Q9R248; Q9WU46;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein 2; Short=ClC-2; (CAVPO7_51.PE12).
GN   Name=CLCN2;
OS   CAVIA PORCELLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAVPO7_51.PE12.
CC       Cavia porcellus scaffold scaffold_7 cavPor3 partial sequence
CC       49315865..50315864 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN2_CAVPO
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9WU45-1; Sequence=Displayed;
CC       Name=2; Synonyms=Delta77-86;
CC         IsoId=Q9WU45-2; Sequence=VSP_001041, VSP_001042;
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The absence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as channels (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-2/CLCN2 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Cavia_porcellus;ENSCPOG00000009200;ENSCPOT00000009284;ENSCPOP00000008261.
DR   EMBL; AF113528; - ;
DR   EMBL; AF113529; - ;
DR   EMBL; AF113530; - ;
DR   UniProtKB/Swiss-Prot; Q9WU45; Q9R247; Q9R248; Q9WU46; -.
DR   EMBL; AF113528; AAD37111.1; -; Genomic_DNA.
DR   EMBL; AF113528; AAD37112.1; -; Genomic_DNA.
DR   EMBL; AF113529; AAD37113.1; -; mRNA.
DR   EMBL; AF113530; AAD37114.1; -; mRNA.
DR   ProteinModelPortal; Q9WU45; -.
DR   SMR; Q9WU45; 770-845.
DR   Ensembl; ENSCPOT00000009284; ENSCPOP00000008261; ENSCPOG00000009200.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; Q9WU45; -.
DR   OrthoDB; EOG4G7BXQ; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   InterPro; IPR002244; Cl-channel-2.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 1.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01113; CLCHANNEL2.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; CAVPO7_51.PE12; -.
KW   ENSCPOG00000009200fold_1320000031; ENSCPOP00000008261fold_1320000031;
KW   AF113528; AF113529; AF113530;
KW   Alternative splicing; CBS domain; Chloride; Chloride channel;
KW   Ion transport; Ionic channel; Membrane; Repeat; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
SQ   SEQUENCE   877 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MYGRYTQELG AFAKEEAARI RLGGPEPWKG PPSPRVPPEL LEYGQSRCAP CCICSVRCHK
     FLVSRVGEDW IFLVLLGLLM ALVSWAMDYA IAVCLQAQQW MSQGLNTNIL LQYLAWVTYP
     VVLITFSAGF TQILAPQAVG SGIPEMKTIL RGVVLKEYLT LKTFVAKVIG LTCALGSGMP
     LGKEGPFVHI ASMCASLLSK FLSLFGGIYE NESRNTEMLA AACAVGVGCC FAAPIGGVLF
     SIEPSTFFAV PNYWPSFFAA FSAFIFRVLA VWNRDEETIT ALFKTRFRLD FPFDLQELPA
     FAVIGIASGF GGALFVYLNR KIVQVMRKQK TINRFLMRKR LLFPALVTLL ISTLTFPPGF
     GQFMAGQLSQ KETLVTLFDN RTWVHQGLVE EQEPPSTSQA WNPPRANVFL TLVIFILMKF
     WMSALATTIP VPCGAFMPVF VIGAAFGRLV GESMAAWFPD GIHTDGSTYR IVPGGYAVVG
     AAALAGAVTH TVSTAVIVFE LTGQIAHILP VMIAVILANA VAQSLQPSLY DSIIRIKKLP
     YLPELGWGRH QQYRVRVEDI MVRDVPYVAL NCTFRDLRLA LHRTKGRMLA LVESSESMIL
     LGSIERSQVV TLLGAQLSAA RRRQHMQERR KAQMSPPSDQ DGLPSPESSV HFQVNTEDSA
     FIPARGETHK PLKPALKRGP SNASKVGETS TGSMESAGIA LRSLFCGSPP PEATSDLEKP
     ESCEKRKLKR VRISLANDAD LEGEMSPEEI LEWEEQQLNE PVNFSDCKID PAPFQLVERT
     SLHKTHTIFS LLGVDHAYVT SIGRLIGIVT LKELRKAIEG SVTAQGVKVR PPLASFRDSA
     TSSSDTETTE VHALWGPHSC HGLPRDGSPS DSDDKCQ
//

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