(data stored in ACNUC9552 zone)

HOGENOM: CHICK20_PE304

ID   CHICK20_PE304                        STANDARD;      PRT;   229 AA.
AC   CHICK20_PE304; Q07816; Q98908;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bcl-2-like protein 1; Short=Bcl2-L-1;AltName:
DE   Full=Apoptosis regulator Bcl-X; (CHICK20.PE304).
GN   Name=BCL2L1; Synonyms=BCL-X, BCLX;
OS   GALLUS GALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Sauropsida; Sauria; Archosauria;
OC   Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae;
OC   Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CHICK20.PE304.
CC       Gallus gallus chromosome 20 WASHUC2  sequence 1..13986235 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B2CL1_CHICK
CC   -!- FUNCTION: Dominant regulator of apoptotic cell death. The long
CC       form displays cell death repressor activity, whereas the short
CC       isoform promotes apoptosis (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC       protein (By similarity). Nucleus membrane; Single-pass membrane
CC       protein; Cytoplasmic side (By similarity). Note=Mitochondrial
CC       membranes and perinuclear envelope (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=Q07816-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=Q07816-2; Sequence=VSP_000514;
CC   -!- TISSUE SPECIFICITY: Highest expression in organs with lymphoid
CC       development.
CC   -!- DOMAIN: The BH4 motif seems to be involved in the anti-apoptotic
CC       function. Intact BH1 and BH2 motifs are required for anti-
CC       apoptotic activity (By similarity).
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC   -!- GENE_FAMILY: HOG000056452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Gallus_gallus;ENSGALG00000006211;ENSGALT00000010073;ENSGALP00000010059.
DR   EMBL; AF432511; - ;
DR   EMBL; GU230783; - ;
DR   EMBL; U26645; - ;
DR   EMBL; Z23110; - ;
DR   UniProtKB/Swiss-Prot; Q07816; Q98908; -.
DR   EMBL; Z23110; CAA80657.1; -; Genomic_DNA.
DR   EMBL; U26645; AAB07677.1; -; mRNA.
DR   IPI; IPI00576590; -.
DR   IPI; IPI00594932; -.
DR   PIR; A47537; A47537.
DR   RefSeq; NP_001020475.1; NM_001025304.1.
DR   UniGene; Gga.4944; -.
DR   ProteinModelPortal; Q07816; -.
DR   SMR; Q07816; 1-204.
DR   STRING; Q07816; -.
DR   Ensembl; ENSGALT00000010073; ENSGALP00000010059; ENSGALG00000006211.
DR   GeneID; 373954; -.
DR   KEGG; gga:373954; -.
DR   CTD; 598; -.
DR   eggNOG; veNOG15148; -.
DR   InParanoid; Q07816; -.
DR   OMA; NGSPSWH; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013279; Apop_reg_BclX.
DR   InterPro; IPR002475; Bcl2-like_apoptosis.
DR   InterPro; IPR000712; Bcl2_BH.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR020728; Bcl2_BH3_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR020731; Bcl2_BH4_motif_CS.
DR   InterPro; IPR004725; Bcl2_reg.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01864; APOPREGBCLX.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   TIGRFAMs; TIGR00865; Bcl-2; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
DR   PROSITE; PS01259; BH3; 1.
DR   PROSITE; PS01260; BH4_1; 1.
DR   PROSITE; PS50063; BH4_2; 1.
DR   HOGENOMDNA; CHICK20.PE304; -.
KW   ENSGALG00000006211fold_1320000031; ENSGALP00000010059fold_1320000031;
KW   D2XQ55_CHICK; Q8UWJ1_CHICK; AF432511; GU230783; U26645; Z23110;
KW   Alternative splicing; Apoptosis; Complete proteome; Membrane;
KW   Mitochondrion; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   229 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSSNRELVI DFVSYKLSQR GHCWSELEEE DENRTDTAAE AEMDSVLNGS PSWHPPAGHV
     VNGATVHRSS LEVHEIVRAS DVRQALRDAG DEFELRYRRA FSDLTSQLHI TPGTAYQSFE
     QVVNELFHDG VNWGRIVAFF SFGGALCVES VDKEMRVLVG RIVSWMTTYL TDHLDPWIQE
     NGGWERFVDL YGNNAAAELR KGQETFNKWL LTGATVAGVL LLGSLLSRK
//

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