(data stored in ACNUC8465 zone)

HOGENOM: CHICK21_PE322

ID   CHICK21_PE322                        STANDARD;      PRT;   191 AA.
AC   CHICK21_PE322; Q90694;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Cell division control protein 42 homolog;AltName: Full=G25K
DE   GTP-binding protein;Flags: Precursor; (CHICK21.PE322).
GN   Name=CDC42;
OS   GALLUS GALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Sauropsida; Sauria; Archosauria;
OC   Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae;
OC   Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CHICK21.PE322.
CC       Gallus gallus chromosome 21 WASHUC2  sequence 1..6959642 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CDC42_CHICK
CC   -!- FUNCTION: Plasma membrane-associated small GTPase which cycles
CC       between an active GTP-bound and an inactive GDP-bound state. In
CC       active state binds to a variety of effector proteins to regulate
CC       cellular responses. Involved in epithelial cell polarization
CC       processes. Plays a role in the extension and maintenance of the
CC       formation of thin, actin-rich surface projections called filopodia
CC       (By similarity).
CC   -!- ENZYME REGULATION: Regulated by guanine nucleotide exchange
CC       factors (GEFs) which promote the exchange of bound GDP for free
CC       GTP, GTPase activating proteins (GAPs) which increase the GTP
CC       hydrolysis activity, and GDP dissociation inhibitors which inhibit
CC       the dissociation of the nucleotide from the GTPase (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       CDC42 subfamily.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Gallus_gallus;ENSGALG00000004796;ENSGALT00000034897;ENSGALP00000034254.
DR   EMBL; U40848; - ;
DR   UniProtKB/Swiss-Prot; Q90694; -.
DR   EMBL; U40848; AAC00027.1; -; mRNA.
DR   IPI; IPI00598959; -.
DR   RefSeq; NP_990379.1; NM_205048.1.
DR   UniGene; Gga.4438; -.
DR   ProteinModelPortal; Q90694; -.
DR   SMR; Q90694; 1-179.
DR   MINT; MINT-126406; -.
DR   STRING; Q90694; -.
DR   PRIDE; Q90694; -.
DR   Ensembl; ENSGALT00000034897; ENSGALP00000034254; ENSGALG00000004796.
DR   GeneID; 395917; -.
DR   KEGG; gga:395917; -.
DR   CTD; 998; -.
DR   eggNOG; veNOG11688; -.
DR   GeneTree; ENSGT00560000076570; -.
DR   InParanoid; Q90694; -.
DR   OrthoDB; EOG4R23VV; -.
DR   PhylomeDB; Q90694; -.
DR   GO; GO:0005912; C:adherens junction; ISS:AgBase.
DR   GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR   GO; GO:0030175; C:filopodium; ISS:AgBase.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; ISS:AgBase.
DR   GO; GO:0046847; P:filopodium assembly; ISS:AgBase.
DR   GO; GO:0045185; P:maintenance of protein location; ISS:AgBase.
DR   GO; GO:0031333; P:negative regulation of protein complex assembly; ISS:AgBase.
DR   GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:AgBase.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:AgBase.
DR   GO; GO:0031274; P:positive regulation of pseudopodium assembly; ISS:AgBase.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; CHICK21.PE322; -.
KW   ENSGALG00000004796fold_1320000031; ENSGALP00000034254fold_1320000031;
KW   U40848;
KW   Cell membrane; Complete proteome; Differentiation; GTP-binding;
KW   Lipoprotein; Membrane; Methylation; Neurogenesis; Nucleotide-binding;
KW   Prenylation; Reference proteome.
SQ   SEQUENCE   191 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
     QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR
     DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP
     EPKKTRRCVL L
//

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