(data stored in ACNUC8465 zone)

HOGENOM: CHICK28_PE138

ID   CHICK28_PE138                        STANDARD;      PRT;   398 AA.
AC   CHICK28_PE138; Q90891;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2;
DE   Short=MAP kinase kinase 2; Short=MAPKK 2; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 2;AltName: Full=MAPK/ERK kinase 2; Short=MEK2;
DE   (CHICK28.PE138).
GN   Name=MAP2K2; Synonyms=MEK2, MKK2, PRKMK2;
OS   GALLUS GALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Sauropsida; Sauria; Archosauria;
OC   Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae;
OC   Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CHICK28.PE138.
CC       Gallus gallus chromosome 28 WASHUC2  sequence 1..4512026 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K2_CHICK
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- PTM: Activated by phosphorylation on Ser/Thr catalyzed by MAP
CC       kinase kinase kinases (RAF) (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Gallus_gallus;ENSGALG00000001267;ENSGALT00000001934;ENSGALP00000001932.
DR   EMBL; L28703; - ;
DR   UniProtKB/Swiss-Prot; Q90891; -.
DR   EMBL; L28703; AAA75576.1; -; mRNA.
DR   IPI; IPI00596185; -.
DR   RefSeq; NP_990719.1; NM_205388.1.
DR   UniGene; Gga.2391; -.
DR   ProteinModelPortal; Q90891; -.
DR   SMR; Q90891; 58-390.
DR   STRING; Q90891; -.
DR   PRIDE; Q90891; -.
DR   GeneID; 396349; -.
DR   KEGG; gga:396349; -.
DR   CTD; 5605; -.
DR   eggNOG; veNOG05046; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q90891; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; Q90891; -.
DR   BRENDA; 2.7.12.2; 1306.
DR   Reactome; REACT_25035; Innate immune response mediated by toll like receptors.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0035419; P:activation of MAPK activity involved in innate immune response; TAS:Reactome.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0035681; P:toll-like receptor 15 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0035682; P:toll-like receptor 21 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   GO; GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
DR   GO; GO:0034154; P:toll-like receptor 7 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; CHICK28.PE138; -.
KW   ENSGALG00000001267fold_1320000031; ENSGALP00000001932fold_1320000031;
KW   L28703;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   398 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPAKRKPVLP ALTITPSPAE GPGPGGSAEA NLVDLQKKLE ELELDEQQKK RLEAFLTQKA
     KVGELKDDDF ERISELGAGN GGVVTKVQHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL
     HECNSPYIVG FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA
     YLREKHQIMH RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT
     HYSVQSDIWS MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPRARPPG
     RPISGHGMDS RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK NPAERADLKM
     LMNHTFIKRS EVEEVDFAGW LCKTLRLNQP STPTRAAV
//

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