(data stored in SCRATCH3701 zone)

HOGENOM6: CLOAI_1_PE1268

ID   CLOAI_1_PE1268                       STANDARD;      PRT;   874 AA.
AC   CLOAI_1_PE1268; B0VIP6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (CLOAI_1.PE1268).
GN   Name=gyrA; OrderedLocusNames=CLOAM1331;
OS   CANDIDATUS CLOACAMONAS ACIDAMINOVORANS.
OC   Bacteria; candidate division WWE1; Candidatus Cloacamonas.
OX   NCBI_TaxID=456827;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CLOAI_1.PE1268.
CC       Candidatus Cloacamonas acidaminovorans.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:B0VIP6_CLOAI
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B0VIP6; -.
DR   EMBL; CU466930; CAO81187.1; -; Genomic_DNA.
DR   RefSeq; YP_001741393.1; NS_000195.1.
DR   ProteinModelPortal; B0VIP6; -.
DR   GeneID; 7193544; -.
DR   GenomeReviews; CU466930_GR; CLOAM1331.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; CLOAI_1.PE1268; -.
DR   PRODOM; CLOAI_1_PE1268.
DR   SWISS-2DPAGE; CLOAI_1_PE1268.
KW   DNA gyrase, A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   874 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSETTNIIPV QIEEQLKQAY LDYSMSVIVS RALPDIRDGL KPSQRRIIYA MHELNLTPGS
     HFRKCAKIAG DTSGNYHPHG EQVVYPTLVR LAQPWIMRYP LIEGQGNFGS IDGDPPAAMR
     YTEARLQKIT MEMLTELEKD TVEFRSNYDE TRQEPTVFPA RFPNLLVNGS SGIAVGMATN
     MPPHNIGEVC DAIIALIDNP DLQPLDLLEY IKGPDFPTGG FILGTEGIRE YFETGRGKII
     MRGETEIETL PNDIEQIIIR SIPYQLSTSQ LIERMVELVK DKKIEGISDI RDESGRDGMR
     IVIQVKRNHD AQVVRNLLYK YTQLQSTFGV INLCLIDGVP QVVNMKEMLQ NFIDFRHEVV
     LRRTQFDLRN AKERLHILEG LKIALDNLDE VIALIRASQT PNDASVGLQE KFGLSEIQAK
     AILDMRLQRL TGLERDKIET EYQELLIIIA RLTELVEHKE LRMNLIKEET AEIRDKFADK
     RLTTIIPAPA GSFNMEDLIA DEMVVVTITH DGYVKRLPVD TYKVQARGGK GLSASNLKEE
     DFIQYLFVAS THSYILLFTD HGMCYWLKVF EIPEASRTAR GKAIVNLVKL AEGDRIKAFV
     TLKDFHPEQN IVMCTRNGLV KKTPLTAFSH PRSIGIKAIK LREGDELIDA RICEAGDDIL
     LATHDGKCNR FSESEIRSMR RFSQGVKGIR LRNGDYVISM TIATAQDQLE NGKPNSSTIL
     AISEKGYGKR SPISSYSVTR RGSMGVITLK TNERNGYLAA LMLVRDDDDL MIITQGGMII
     RQRVSEISVV GRNTLGVRLI NLAPNDVVRD ISLVHSEPDE ESLDKEVETL KAKPASNLEE
     FADGEDEEFA EEDEEEIEEM DESEEDLENE EDNE
//

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