(data stored in ACNUC7421 zone)

HOGENOM: CLOBH_1_PE1001

ID   CLOBH_1_PE1001                       STANDARD;      PRT;   468 AA.
AC   CLOBH_1_PE1001; A5I0N4; A7G2E6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Sensor histidine kinase; EC=2.7.3 -;SubName:
DE   Full=Two-component sensor kinase;Flags: Precursor; (CLOBH_1.PE1001).
GN   OrderedLocusNames=CBO1042, CLC_1094;
OS   CLOSTRIDIUM BOTULINUM A STR. HALL.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CLOBH_1.PE1001.
CC       Clostridium botulinum A str. Hall, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:A5I0N4_CLOBH
CC   -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
CC       phospho-L-histidine.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 histidine kinase domain.
CC   -!- GENE_FAMILY: HOG000245618 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A5I0N4; A7G2E6; -.
DR   EMBL; CP000727; ABS36296.1; -; Genomic_DNA.
DR   EMBL; AM412317; CAL82595.1; -; Genomic_DNA.
DR   RefSeq; YP_001253573.1; NC_009495.1.
DR   RefSeq; YP_001386961.1; NC_009698.1.
DR   ProteinModelPortal; A5I0N4; -.
DR   STRING; A5I0N4; -.
DR   GeneID; 5185297; -.
DR   GeneID; 5399993; -.
DR   GenomeReviews; AM412317_GR; CBO1042.
DR   GenomeReviews; CP000727_GR; CLC_1094.
DR   KEGG; cbh:CLC_1094; -.
DR   KEGG; cbo:CBO1042; -.
DR   eggNOG; COG0642; -.
DR   OMA; EPVTKEM; -.
DR   ProtClustDB; CLSK971828; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:two-component sensor activity; IEA:InterPro.
DR   GO; GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
DR   InterPro; IPR003594; ATPase-like_ATP-bd.
DR   InterPro; IPR003660; HAMP_linker_domain.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR003661; Sig_transdc_His_kin_sub1_dim/P.
DR   InterPro; IPR005467; Sig_transdc_His_kinase_core.
DR   InterPro; IPR009082; Sig_transdc_His_kinase_dimeric.
DR   Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF55874; ATP_bd_ATPase; 1.
DR   SUPFAM; SSF47384; His_kin_homodim; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   HOGENOMDNA; CLOBH_1.PE1001; -.
KW   sensor histidine kinase;
KW   ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Signal; Transferase;
KW   Transmembrane; Two-component regulatory system.
SQ   SEQUENCE   468 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKMSLKKKLS LGFLIAVIGS IIIASSISNY MINNRFNEYL VQEHKNKINQ IIVAIEDMYK
     EDKGFQALKY DEIKRYAVLN ELYIEIKDKK GSKIFTSGDD HLKHRSMMNS MMGHGMGNMM
     GKMKNLDLGD YKEEEQWLKK NNVTFGKITI GYFGTSYLNN GALTFKRTLN HSFIVSMVIT
     FILGLILSWI LSKQLSKPLV KIKEIANTMR MGNLNIRSNI KSNTTEIQEL SNSINYLAET
     LQQQEALRKR LTSDMAHEIR TPITTLKTHV EAIIDGIWEP TEERLQVFYE ELERLTNLVN
     NLRNISKLEK AETVVNKTNL NITKEIEKVV ETFNPLYEKS GFKIVTKLEK DVYGFIDKDK
     LKQIMHNLLS NSHKYLNEDG LVKVSLSKGK DKIFIKVEDN GEGIPEEDLP HIFERFYRSD
     VSRNKTTGGT GLGLTITKTL VEAHGGHIRV ESKMGVGTKF IIEIKTTL
//

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