(data stored in ACNUC9435 zone)

HOGENOM: CLOD6_2_PE1

ID   CLOD6_2_PE1                          STANDARD;      PRT;   439 AA.
AC   CLOD6_2_PE1; Q18C85;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
DE   (CLOD6_2.PE1).
GN   Name=dnaA; OrderedLocusNames=CD630_00010;
OS   CLOSTRIDIUM DIFFICILE 630.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272563;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CLOD6_2.PE1.
CC       Clostridium difficile 630 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:Q18C85_CLOD6
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC   -!- SIMILARITY: Belongs to the dnaA family.
CC   -!- GENE_FAMILY: HOG000235658 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q18C85; -.
DR   EMBL; AM180355; CAJ66815.1; -; Genomic_DNA.
DR   RefSeq; YP_001086464.1; NC_009089.1.
DR   ProteinModelPortal; Q18C85; -.
DR   STRING; Q18C85; -.
DR   GeneID; 4913287; -.
DR   GenomeReviews; AM180355_GR; CD0001.
DR   KEGG; cdf:CD0001; -.
DR   NMPDR; fig|1496.1.peg.3674; -.
DR   eggNOG; COG0593; -.
DR   OMA; IQRVVGQ; -.
DR   ProtClustDB; PRK00149; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:HAMAP.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA-dependent DNA replication initiation; IEA:HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00377; DnaA_bact; 1; -.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR013317; DnaA_Hda.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   Gene3D; G3DSA:1.10.1750.10; DnaA_C; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; Trp_repress_rep; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
DR   HOGENOMDNA; CLOD6_2.PE1; -.
KW   chromosomal replication initiator protein;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding.
SQ   SEQUENCE   439 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDIVSLWDKT LQLIKGDLTS VSFNTFFKNI VPLKIHLNDL ILLAPSDFNK DILENRYLHL
     IEDAISQLSL KKYNIKFVLS EKEVADLNSD STDLNYRVLY PNLNPKYTFD TFVIGNSNRF
     AHAACVAVAE SPAKAYNPLF LYGGVGLGKT HLMHAIGHHI VSQKKDSKVV YVSSEKFTNE
     LINSIKDDKN EEFRNKYRNV DVLLIDDIQF IAGKERTQEE FFHTFNTLHE ANKQIIISSD
     RPPKDIPTLE DRLRSRFEMG LITDIQAPDF ETRIAILRKK AQLERIDVPN EVMSYIAKNI
     KSNIRELEGA LTRVVAYSSL SNRVISFDLA TEALKDIITT SKNEEINVLR IKEKVSSVFN
     LKMEDFNSKK RTRSIAYPRQ IAMYLTRELT DLSLPKIGEE FGGRDHTTVI HAHDKVSKDI
     EESEEIKTKI DKIISDLKG
//

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