(data stored in SCRATCH zone)

HOGENOM: CROTZ_1_PE1001

ID   CROTZ_1_PE1001                       STANDARD;      PRT;   304 AA.
AC   CROTZ_1_PE1001; C9XX86;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=2-dehydropantoate 2-reductase; EC=1.1.1 169;
DE   (CROTZ_1.PE1001).
GN   Name=panE; OrderedLocusNames=Ctu_10010; ORFNames=CTU_10010;
OS   CRONOBACTER TURICENSIS Z3032.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=693216;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CROTZ_1.PE1001.
CC       Cronobacter turicensis z3032, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C9XX86_CROTZ
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC       into pantoic acid (By similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate +
CC       NADPH.
CC   -!- PATHWAY: Cofactor biosynthesis; pantothenate biosynthesis;
CC       pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC   -!- GENE_FAMILY: HOG000050223 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C9XX86; -.
DR   EMBL; FN543093; CBA28603.1; -; Genomic_DNA.
DR   RefSeq; YP_003209364.1; NC_013282.2.
DR   ProteinModelPortal; C9XX86; -.
DR   STRING; C9XX86; -.
DR   GeneID; 8461872; -.
DR   GenomeReviews; FN543093_GR; Ctu_10010.
DR   KEGG; ctu:Ctu_10010; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; ApbA_C.
DR   InterPro; IPR013332; ApbA_N.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR   TIGRFAMs; TIGR00745; ApbA_panE; 1.
DR   HOGENOMDNA; CROTZ_1.PE1001; -.
KW   2-dehydropantoate 2-reductase;
KW   Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis.
SQ   SEQUENCE   304 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKITVLGCGA LGQLWMSALH KQGHEVQGWL RVPQSSYNVS LVETDHSAFQ HTFTTNDSGF
     LAQSELLLVT LKAWQVSDAV STLATRLPAA SPILLLHNGM GTLDELRAVQ QPLLAGVTTH
     AARREGNLVI HVACGTTHIG PVTPGAQDYS RLAELLQQAL PDVAWHDNVN VSRWIKLAAN
     CVINPLTALS NCPNGDLRAR QDEVRDICAE VALVMQREGH HTSPESLLYY INQVIDSTAA
     NISSMLQDVR QQRHTEIDYI TGYLLRRARA HGLTLPVNSR LYEQIKRKED EYERIGTGMP
     RPWH
//

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