(data stored in ACNUC14376 zone)

HOGENOM: DANRE12_30_PE24

ID   DANRE12_30_PE24                      STANDARD;      PRT;   494 AA.
AC   DANRE12_30_PE24; Q9PUQ1; O57586;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ETS translocation variant 4;AltName: Full=Polyomavirus
DE   enhancer activator 3 homolog; Short=Protein PEA3; (DANRE12_30.PE24).
GN   Name=etv4; Synonyms=pea3;
OS   DANIO RERIO.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala;
OC   Clupeocephala; Otocephala; Ostariophysi; Otophysi; Cypriniphysi;
OC   Cypriniformes; Cyprinoidea; Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DANRE12_30.PE24.
CC       Danio rerio chromosome 12 Zv9 partial sequence 28447412..29275262 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ETV4_DANRE
CC   -!- FUNCTION: Transcriptional activator that binds to the (5'-
CC       CCGGA[AT]-3') motif. May control the acquisition of specific cell
CC       fates at an early stage during development of the somites and
CC       nervous system. May mediate the cellular effects of the fibroblast
CC       growth factors on embryogenesis.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: In the embryo, expressed ubiquitously until
CC       the late blastula stage, in the marginal zone of gastrula stages,
CC       in the presumptive forebrain and hindbrain and in the trunk region
CC       of early somite stages. In later stages, also expressed in Rohon-
CC       Beard neurons, epiphysis, lateral line placodes, pectoral fin
CC       buds, developing lens and heart.
CC   -!- DEVELOPMENTAL STAGE: First detected in the embryo after 4.3 hours.
CC   -!- INDUCTION: By the fibroblast growth factors FGF3 and FGF8.
CC   -!- PTM: Phosphorylated (Probable).
CC   -!- MISCELLANEOUS: Transcriptional activation activity is enhanced by
CC       Raf1, ERK and PKA.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC   -!- SIMILARITY: Contains 1 ETS DNA-binding domain.
CC   -!- GENE_FAMILY: HOG000230986 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Danio_rerio;ENSDARG00000018303;ENSDART00000013033;ENSDARP00000016969.
DR   EMBL; AF168008; - ;
DR   EMBL; AJ003200; - ;
DR   EMBL; BC066500; - ;
DR   UniProtKB/Swiss-Prot; Q9PUQ1; O57586; -.
DR   EMBL; AJ003200; CAA05980.1; -; mRNA.
DR   EMBL; AF168008; AAD50434.1; -; mRNA.
DR   IPI; IPI00510635; -.
DR   RefSeq; NP_571500.1; NM_131425.1.
DR   UniGene; Dr.75840; -.
DR   ProteinModelPortal; Q9PUQ1; -.
DR   SMR; Q9PUQ1; 348-437.
DR   STRING; Q9PUQ1; -.
DR   GeneID; 30700; -.
DR   KEGG; dre:30700; -.
DR   CTD; 30700; -.
DR   ZFIN; ZDB-GENE-990415-71; pea3.
DR   eggNOG; fiNOG09250; -.
DR   GeneTree; ENSGT00600000083997; -.
DR   InParanoid; Q9PUQ1; -.
DR   OrthoDB; EOG4W0XCT; -.
DR   Bgee; Q9PUQ1; -.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; NAS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
DR   InterPro; IPR000418; Ets.
DR   InterPro; IPR006715; ETS_PEA3_N.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF04621; ETS_PEA3_N; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   HOGENOMDNA; DANRE12_30.PE24; -.
KW   ENSDARG000000183035old_1320000031; ENSDARP000000169691old_1320000031;
KW   Q6NYQ6_DANRE; AF168008; AJ003200; BC066500;
KW   Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
SQ   SEQUENCE   494 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDYKMDGYLD QQVPYTLANR SQGNGPLNRL LMATKRKYMD AELPPQESED LFQDLSQLQE
     TWLTEAQVPD SDEQFVPDFH SENSVAFHSP PVKIKKEPQS PGSDPSQSCS HKQSFSYPNG
     EQCLYASAYE QKRAAVAGAG GSKSSCPGTP MSPMQHYSPK PTVGTRQESG YMNPPSASQS
     HACHSHSYPM NPSSRFPSGS AEMCPPFASQ GQALQRMHPA HASGGGGGGY HRQHSDPCLP
     YPPQQTFKQE YMDPLYDRAA HINGPQPQRF PPAHMMVKQE PTDYTYEPDV PGCPSMYHHN
     EGYSNPQHNS EGYMFENDSR VVPEKFEGEV KQEGGSVFRE GAPYQRRGSL QLWQFLVALL
     DDPSNAHFIA WTGRGMEFKL IEPEEVARLW GMQKNRPAMN YDKLSRSLRY YYEKGIMQKV
     AGERYVYKFV CEPEALISLA FPDNQRPSLK AEFERYVNEE DTVPLSHLDE GVSYPPEPAA
     TNMGPQPYSK GYMY
//

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