(data stored in ACNUC8465 zone)

HOGENOM: DANRE12_39_PE7

ID   DANRE12_39_PE7                       STANDARD;      PRT;   361 AA.
AC   DANRE12_39_PE7; Q9DGE0; Q6IQW6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 6;
DE   Short=MAP kinase kinase 6; Short=MAPKK 6; EC=2.7.12 2;AltName:
DE   Full=Mitogen-activated protein kinase kinase 3; Short=zMKK3;
DE   (DANRE12_39.PE7).
GN   Name=map2k6; Synonyms=map2k3;
OS   DANIO RERIO.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala;
OC   Clupeocephala; Otocephala; Ostariophysi; Otophysi; Cypriniphysi;
OC   Cypriniformes; Cyprinoidea; Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DANRE12_39.PE7.
CC       Danio rerio chromosome 12 Zv9 partial sequence 37186334..38186333 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K6_DANRE
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in MAP kinase p38 exclusively. This
CC       phosphorylation asymmetrically activates p38 on one side of the
CC       blastodisc, an event which is necessary for blastomere cleavage.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Zygotic expression continues throughout development.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- CAUTION: Was originally (PubMed:10995439) thought to be a Map2k3
CC       protein but sequence analysis shows closer similarity to the
CC       Map2k6 proteins.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH71285.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Danio_rerio;ENSDARG00000005567;ENSDART00000129683;ENSDARP00000107541.
DR   EMBL; AB030899; - ;
DR   EMBL; BC044129; - ;
DR   EMBL; BC071285; - ;
DR   UniProtKB/Swiss-Prot; Q9DGE0; Q6IQW6; -.
DR   EMBL; AB030899; BAB11809.1; -; mRNA.
DR   EMBL; BC044129; AAH44129.1; -; mRNA.
DR   EMBL; BC071285; AAH71285.1; ALT_INIT; mRNA.
DR   IPI; IPI00480961; -.
DR   RefSeq; NP_571799.1; NM_131724.1.
DR   UniGene; Dr.150491; -.
DR   HSSP; P36507; 1S9I.
DR   ProteinModelPortal; Q9DGE0; -.
DR   STRING; Q9DGE0; -.
DR   Ensembl; ENSDART00000129683; ENSDARP00000107541; ENSDARG00000005567.
DR   GeneID; 65239; -.
DR   KEGG; dre:65239; -.
DR   CTD; 5608; -.
DR   ZFIN; ZDB-GENE-010202-3; map2k6.
DR   eggNOG; fiNOG12009; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; Q9DGE0; -.
DR   ArrayExpress; Q9DGE0; -.
DR   Bgee; Q9DGE0; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; DANRE12_39.PE7; -.
KW   ENSDARG000000055675old_1320000031; ENSDARP000001075411old_1320000031;
KW   AB030899; BC044129; BC071285;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   361 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEGGSDKESK VFCDSPSPNP KGEMSVPSNV RGKKKLPKEL KLPKEVFEKP APAPTPPRDL
     DSKAYVTIGE KNFVVKADDL EQIGELGRGA YGVVDKMRHV PSGVIMAVKR IRATVNTQEQ
     KRLLMDLDIS MRTVDCFYTV TFYGALFREG DVWICMELMD TSLDKFYKQV HEKGKTIPED
     ILGKITVSIV KALEHLHSNL SVIHRDVKPS NVLINMQGQV KMCDFGISGY LVDSVAKTMD
     AGCKPYMAPE RINPETNQKG YNVKSDIWSL GITMIELAIL RFPYDSWGTP FQQLKQVVEE
     PSPQLPADRF SADFVDFTSQ CLRKNSTERP TYTELMQHPF FTLHDSKDTD VASFVKTILG
     D
//

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