(data stored in ACNUC14452 zone)

HOGENOM: DANRE19_30_PE11

ID   DANRE19_30_PE11                      STANDARD;      PRT;   517 AA.
AC   DANRE19_30_PE11; Q1LWG4; A1L1Q0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Lysophosphatidylcholine acyltransferase 1; Short=LPC
DE   acyltransferase 1; Short=LPCAT-1; Short=LysoPC acyltransferase 1;
DE   EC=2.3.1.-;AltName: Full=1-acylglycerophosphocholine O-acyltransferase;
DE   EC=2.3.1.23;AltName: Full=1-alkylglycerophosphocholine
DE   O-acetyltransferase; EC=2.3.1 67;AltName:
DE   Full=Acetyl-CoA:lyso-platelet-activating factor acetyltransferase;
DE   Short=Acetyl-CoA:lyso-PAF acetyltransferase; Short=Lyso-PAF
DE   acetyltransferase; Short=LysoPAFAT;AltName: Full=Acyltransferase-like 2;
DE   (DANRE19_30.PE11).
GN   Name=lpcat1; Synonyms=aytl2; ORFNames=si:dkey-261i16.4, zgc:158232;
OS   DANIO RERIO.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala;
OC   Clupeocephala; Otocephala; Ostariophysi; Otophysi; Cypriniphysi;
OC   Cypriniformes; Cyprinoidea; Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DANRE19_30.PE11.
CC       Danio rerio chromosome 19 Zv9 partial sequence 28321578..29321577 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PCAT1_DANRE
CC   -!- FUNCTION: Possesses both acyltransferase and acetyltransferase
CC       activities. Activity is calcium-independent. Mediates the
CC       conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into
CC       phosphatidylcholine (PC) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CC       = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + 1-alkyl-sn-glycero-3-
CC       phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-
CC       phosphocholine.
CC   -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type II membrane protein (By similarity). Golgi apparatus
CC       membrane; Single-pass type II membrane protein (By similarity).
CC   -!- DOMAIN: The HXXXXD motif is essential for acyltransferase activity
CC       and may constitute the binding site for the phosphate moiety of
CC       the glycerol-3-phosphocholine (By similarity).
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum
CC       localization for type I membrane proteins (By similarity).
CC   -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC       acyltransferase family.
CC   -!- SIMILARITY: Contains 1 EF-hand domain.
CC   -!- GENE_FAMILY: HOG000234374 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Danio_rerio;ENSDARG00000011506;ENSDART00000103855;ENSDARP00000094631.
DR   EMBL; BC129167; - ;
DR   EMBL; BX571830; - ;
DR   UniProtKB/Swiss-Prot; Q1LWG4; A1L1Q0; -.
DR   EMBL; BX571830; CAK10868.1; -; Genomic_DNA.
DR   EMBL; BC129167; AAI29168.1; -; mRNA.
DR   IPI; IPI00497621; -.
DR   RefSeq; NP_001037806.2; NM_001044341.2.
DR   UniGene; Dr.80588; -.
DR   ProteinModelPortal; Q1LWG4; -.
DR   STRING; Q1LWG4; -.
DR   Ensembl; ENSDART00000103855; ENSDARP00000094631; ENSDARG00000011506.
DR   Ensembl; ENSDART00000139433; ENSDARP00000120048; ENSDARG00000011506.
DR   GeneID; 555969; -.
DR   KEGG; dre:555969; -.
DR   CTD; 79888; -.
DR   ZFIN; ZDB-GENE-060503-915; lpcat1.
DR   eggNOG; fiNOG11461; -.
DR   GeneTree; ENSGT00390000004914; -.
DR   InParanoid; Q1LWG4; -.
DR   OMA; RAQSNGK; -.
DR   OrthoDB; EOG49GKGF; -.
DR   ArrayExpress; Q1LWG4; -.
DR   Bgee; Q1LWG4; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0047192; F:1-alkylglycerophosphocholine O-acetyltransferase activity; IEA:EC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR002123; Acyltransferase.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR002048; EF_hand_Ca-bd.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 2.
DR   Pfam; PF01553; Acyltransferase; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00563; PlsC; 1.
DR   PROSITE; PS00018; EF_HAND_1; FALSE_NEG.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   HOGENOMDNA; DANRE19_30.PE11; -.
KW   ENSDARG000000115065old_1320000031; ENSDARP000000946311old_1320000031;
KW   BC129167; BX571830;
KW   Acyltransferase; Calcium; Complete proteome; Endoplasmic reticulum;
KW   Glycoprotein; Golgi apparatus; Membrane; Phospholipid biosynthesis;
KW   Reference proteome; Repeat; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   517 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRFPNRKLHT AVNGGDSGVS THFRNPFVHE LRFTTLQKLK IAVMTVTLFP VRLLFAAFMM
     LLAWPFAFVA TVGRSENAVE PLSWWRWLVD LALKAIMRAM WFSGGFHWVR VKGRPALPSE
     APILTMAPHS SYFDAIPVTM TMASIVMKAE SKDIPVWGTL IKFIRPVFVS RSDQDSRRKT
     VEEIKRRASS NGEWPQIMIF PEGTCTNRSC LIAFKPGAFI PGVPVQPVVL RYPNELDTIS
     WTWQGPGAFK ILWLTLCQLH NFVEIEYLPT YTPSEEEKKD PALFASNVRR IMAKALGLPI
     IDYSFEDCQL AMAKGPLRLP KHTCLLEFAR LVRLLGLKTK VTDEVLQEEA CSARQLCGRR
     LDMEGFAQYL HQPMTEAVQD IFSLFEEHGM MDVREYVIAL SVVCRPFRYL DTVKLAFRMF
     EAQEDGAIVE DELTVILKTA LGVGDLAVSE LFRAIDSQDK GKITFDELCS FMEKCPDLVE
     QYHCLCESIS QHSRESTSSS NGFCADFSPR NHSKKQD
//

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