(data stored in ACNUC27637 zone)

HOGENOM: DANRE22_43_PE40

ID   DANRE22_43_PE40                      STANDARD;      PRT;   155 AA.
AC   DANRE22_43_PE40; Q8JGR6; Q1MT38; Q5XIY9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Nuclear cap-binding protein subunit 2;AltName: Full=20 kDa
DE   nuclear cap-binding protein;AltName: Full=NCBP 20 kDa subunit;
DE   Short=CBP20; (DANRE22_43.PE40).
GN   Name=ncbp2; Synonyms=cbp20; ORFNames=ch211-258l4.5;
OS   DANIO RERIO.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala;
OC   Clupeocephala; Otocephala; Ostariophysi; Otophysi; Cypriniphysi;
OC   Cypriniformes; Cyprinoidea; Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DANRE22_43.PE40.
CC       Danio rerio chromosome 22 Zv9 partial sequence 41085028..42052114 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:NCBP2_DANRE
CC   -!- FUNCTION: Component of the cap-binding complex (CBC), which binds
CC       co-transcriptionally to the 5' cap of pre-mRNAs and is involved in
CC       various processes such as pre-mRNA splicing, translation
CC       regulation, nonsense-mediated mRNA decay, RNA-mediated gene
CC       silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC
CC       complex is involved in mRNA export from the nucleus, leading to
CC       the recruitment of the mRNA export machinery to the 5' end of mRNA
CC       and to mRNA export in a 5' to 3' direction through the nuclear
CC       pore. The CBC complex is also involved in mediating U snRNA and
CC       intronless mRNAs export from the nucleus. The CBC complex is
CC       essential for a pioneer round of mRNA translation, before steady
CC       state translation when the CBC complex is replaced by cytoplasmic
CC       cap-binding protein eIF4E. The pioneer round of mRNA translation
CC       mediated by the CBC complex plays a central role in nonsense-
CC       mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to
CC       the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex
CC       enhances NMD in mRNAs containing at least one exon-junction
CC       complex (EJC), promoting the interaction between upf1 and upf2.
CC       The CBC complex is also involved in 'failsafe' NMD, which is
CC       independent of the EJC complex, while it does not participate in
CC       Staufen-mediated mRNA decay (SMD). During cell proliferation, the
CC       CBC complex is also involved in microRNAs (miRNAs) biogenesis via
CC       its interaction with srrt/ars2, thereby being required for miRNA-
CC       mediated RNA interference. The CBC complex also acts as a negative
CC       regulator of parn, thereby acting as an inhibitor of mRNA
CC       deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and
CC       binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to
CC       stabilize the movement of its N-terminal loop and lock the CBC
CC       into a high affinity cap-binding state with the cap structure (By
CC       similarity).
CC   -!- SUBUNIT: Component of the nuclear cap-binding complex (CBC), a
CC       heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts
CC       with m7GpppG-capped RNA (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the RRM NCBP2 family.
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CC   -!- GENE_FAMILY: HOG000217589 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Danio_rerio;ENSDARG00000014898;ENSDART00000008365;ENSDARP00000020688.
DR   EMBL; AL953867; - ;
DR   EMBL; AY099530; - ;
DR   EMBL; BC083529; - ;
DR   UniProtKB/Swiss-Prot; Q8JGR6; Q1MT38; Q5XIY9; -.
DR   EMBL; AY099530; AAM28218.1; -; mRNA.
DR   EMBL; AL953867; CAK04823.1; -; Genomic_DNA.
DR   EMBL; BC083529; AAH83529.1; -; mRNA.
DR   IPI; IPI00487113; -.
DR   RefSeq; NP_775356.1; NM_173249.1.
DR   UniGene; Dr.83993; -.
DR   HSSP; P52298; 1H6K.
DR   ProteinModelPortal; Q8JGR6; -.
DR   SMR; Q8JGR6; 5-151.
DR   STRING; Q8JGR6; -.
DR   Ensembl; ENSDART00000008365; ENSDARP00000020688; ENSDARG00000014898.
DR   GeneID; 192325; -.
DR   KEGG; dre:192325; -.
DR   CTD; 22916; -.
DR   ZFIN; ZDB-GENE-020419-31; ncbp2.
DR   GeneTree; ENSGT00390000003197; -.
DR   InParanoid; Q8JGR6; -.
DR   OMA; RTDYDAG; -.
DR   OrthoDB; EOG470TJG; -.
DR   ArrayExpress; Q8JGR6; -.
DR   Bgee; Q8JGR6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006370; P:mRNA capping; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0046833; P:positive regulation of RNA export from nucleus; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; ISS:UniProtKB.
DR   GO; GO:0006408; P:snRNA export from nucleus; ISS:UniProtKB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   HOGENOMDNA; DANRE22_43.PE40; -.
KW   ENSDARG000000148985old_1320000031; ENSDARP000000206881old_1320000031;
KW   AL953867; AY099530; BC083529;
KW   Complete proteome; Cytoplasm; mRNA capping; mRNA processing;
KW   mRNA splicing; mRNA transport; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; RNA-binding; RNA-mediated gene silencing;
KW   Translation regulation; Transport.
SQ   SEQUENCE   155 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSIKLNALFS DSYVDVSQYR DQHFKGNRYE QEKLLKQSAT LYVGNLSFYT TEEQVHELFA
     KCGDVKRIII GLDKIKKTAC GFCFVEYYTR ADAENAMRFV NGTRLDDRII RTDWDAGFKE
     GRQYGRGKSG GQVRDEYRQD YDPARGGYGK MVQKS
//

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