(data stored in ACNUC18777 zone)

HOGENOM: DANRE8_49_PE9

ID   DANRE8_49_PE9                        STANDARD;      PRT;   285 AA.
AC   DANRE8_49_PE9; Q9DG10;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Steroidogenic acute regulatory protein, mitochondrial;
DE   Short=StAR;AltName: Full=START domain-containing protein 1;
DE   Short=StARD1;Flags: Precursor; (DANRE8_49.PE9).
GN   Name=star;
OS   DANIO RERIO.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala;
OC   Clupeocephala; Otocephala; Ostariophysi; Otophysi; Cypriniphysi;
OC   Cypriniformes; Cyprinoidea; Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DANRE8_49.PE9.
CC       Danio rerio chromosome 8 Zv9 partial sequence 46412804..47412803 annota
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:STAR_DANRE
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by
CC       enhancing the metabolism of cholesterol into pregnenolone.
CC       Mediates the transfer of cholesterol from the outer mitochondrial
CC       membrane to the inner mitochondrial membrane where it is cleaved
CC       to pregnenolone (By similarity).
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and at lower
CC       levels in the ovary, kidney and head.
CC   -!- SIMILARITY: Contains 1 START domain.
CC   -!- GENE_FAMILY: HOG000142452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Danio_rerio;ENSDARG00000006137;ENSDART00000016225;ENSDARP00000023907.
DR   EMBL; AF220435; - ;
DR   EMBL; BC075967; - ;
DR   UniProtKB/Swiss-Prot; Q9DG10; -.
DR   EMBL; AF220435; AAG28593.1; -; mRNA.
DR   EMBL; BC075967; AAH75967.1; -; mRNA.
DR   IPI; IPI00490329; -.
DR   RefSeq; NP_571738.1; NM_131663.1.
DR   UniGene; Dr.82598; -.
DR   ProteinModelPortal; Q9DG10; -.
DR   STRING; Q9DG10; -.
DR   Ensembl; ENSDART00000016225; ENSDARP00000023907; ENSDARG00000006137.
DR   GeneID; 63999; -.
DR   KEGG; dre:63999; -.
DR   CTD; 6770; -.
DR   ZFIN; ZDB-GENE-001120-3; star.
DR   eggNOG; fiNOG08976; -.
DR   GeneTree; ENSGT00530000063139; -.
DR   InParanoid; Q9DG10; -.
DR   OMA; QEGWKKE; -.
DR   OrthoDB; EOG4JWVF2; -.
DR   PhylomeDB; Q9DG10; -.
DR   ArrayExpress; Q9DG10; -.
DR   Bgee; Q9DG10; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR   GO; GO:0017127; F:cholesterol transporter activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000799; StAR.
DR   InterPro; IPR023393; START-like_dom.
DR   InterPro; IPR002913; START_lipid-bd.
DR   Gene3D; G3DSA:3.30.530.20; G3DSA:3.30.530.20; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
DR   HOGENOMDNA; DANRE8_49.PE9; -.
KW   ENSDARG000000061375old_1320000031; ENSDARP000000239071old_1320000031;
KW   AF220435; BC075967;
KW   Complete proteome; Lipid transport; Lipid-binding; Mitochondrion;
KW   Reference proteome; Steroidogenesis; Transit peptide; Transport.
SQ   SEQUENCE   285 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLPATFKLCA GISYRHMRNM TGLRKNAMIA IHHELNKLSG PGASTWINHI RRRSSLLSSP
     IAEETYSEAD QCYVQQGQEA LQKSISILED QDGWQTEIES INGEKVMSKV LPGIGKVFKL
     EVTLEQQTGD LYDELVDNME QMGEWNPNVK QVKILQKIGQ ETMITHEISA ETPGNVVGPR
     DFVNVRHAKR RGSTCFLAGM STQHPGMPEQ KGFVRAENGP TCIVMRPSAD DPNKTKFTWL
     LSLDLKGWIP KTVINRVLSQ TQVDFVNHLR DRMASGGGID AAIAC
//

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