(data stored in ACNUC7421 zone)

HOGENOM: DEHSB_1_PE1004

ID   DEHSB_1_PE1004                       STANDARD;      PRT;   433 AA.
AC   DEHSB_1_PE1004; A5FQD5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Homoserine dehydrogenase; EC=1.1.1 3; (DEHSB_1.PE1004).
GN   OrderedLocusNames=DehaBAV1_1016;
OS   DEHALOCOCCOIDES SP. BAV1.
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=216389;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DEHSB_1.PE1004.
CC       Dehalococcoides sp. BAV1, complete genome.
CC       / IFO 0083) chromosome G, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:A5FQD5_DEHSB
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC   -!- GENE_FAMILY: HOG000076615 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A5FQD5; -.
DR   EMBL; CP000688; ABQ17596.1; -; Genomic_DNA.
DR   RefSeq; YP_001214474.1; NC_009455.1.
DR   ProteinModelPortal; A5FQD5; -.
DR   STRING; A5FQD5; -.
DR   GeneID; 5131245; -.
DR   GenomeReviews; CP000688_GR; DehaBAV1_1016.
DR   KEGG; deb:DehaBAV1_1016; -.
DR   eggNOG; COG0460; -.
DR   OMA; VHPAMIP; -.
DR   ProtClustDB; CLSK837068; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT-bd.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
DR   HOGENOMDNA; DEHSB_1.PE1004; -.
KW   homoserine dehydrogenase;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis;
KW   NADP; Oxidoreductase; Threonine biosynthesis.
SQ   SEQUENCE   433 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEKKYIGVGV IGLGVVAGQV SKVLCEREEF LSAQLGFPLK LKKVKVLPQD MPRPLAKSLP
     EGVLTTDEDD FFNTPGLDIV VEAIGGEYPA FNLLSRGLKM GKCVVTSNKE VIAKHAPELV
     KLAKDNNVGL RCEASVGGGI PLISPFQYDL AANHINGIYA IINGTTNYIL TRMAKEGLDF
     ATALKQAQSL GYAEANPSND IEGTDAVYKL AIMASINFQC MVKPEDIYRE GISRLTSRDF
     CYADELGFNI KLLAITKPGN GQIEARVHPV FLPKDDWLAK VDGVFNAVLV EGDLVGPVLF
     QGQGAGALAT SSAVVADVLA AAQDIHLGVG NRMRWNMDKP LGIKPMSDIL TRYYLRMTVT
     DSPGVLALIA KVLGDHSISI SSVIQKETDE KNLTAEIVIM THPAKEAFVQ QALVKLGGLD
     KVKEINNFVR VGI
//

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