(data stored in ACNUC7421 zone)

HOGENOM: DEPSY1_1_PE1006

ID   DEPSY1_1_PE1006                      STANDARD;      PRT;   679 AA.
AC   DEPSY1_1_PE1006; Q6API9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA ligase; EC=6.5.1 2;AltName:
DE   Full=Polydeoxyribonucleotide synthase (DEPSY1_1.PE1006) [NAD+]; .
GN   Name=ligA; OrderedLocusNames=DP1006;
OS   DESULFOTALEA PSYCHROPHILA LSV54.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobulbaceae; Desulfotalea.
OX   NCBI_TaxID=177439;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS DEPSY1_1.PE1006.
CC       Desulfotalea psychrophila LSv54, complete genome.
CC       / IFO 0083) chromosome G, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:DNLJ_DESPS
CC   -!- FUNCTION: DNA ligase that catalyzes the formation of
CC       phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl
CC       groups in double-stranded DNA using NAD as a coenzyme and as the
CC       energy source for the reaction. It is essential for DNA
CC       replication and repair of damaged DNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 BRCT domain.
CC   -!- GENE_FAMILY: HOG000078342 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6API9; -.
DR   EMBL; CR522870; CAG35735.1; -; Genomic_DNA.
DR   RefSeq; YP_064742.1; NC_006138.1.
DR   ProteinModelPortal; Q6API9; -.
DR   GeneID; 2944684; -.
DR   GenomeReviews; CR522870_GR; DP1006.
DR   KEGG; dps:DP1006; -.
DR   NMPDR; fig|177439.1.peg.1006; -.
DR   OMA; EDWRFLA; -.
DR   ProtClustDB; CLSK831577; -.
DR   BioCyc; DPSY177439:DP1006-MON; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003911; F:DNA ligase (NAD+) activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01588; DNA_ligase_A; 1; -.
DR   InterPro; IPR001357; BRCT.
DR   InterPro; IPR004150; DNA_ligase_OB.
DR   InterPro; IPR001679; DNAligase.
DR   InterPro; IPR013839; DNAligase_adenylation.
DR   InterPro; IPR013840; DNAligase_N.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF01653; DNA_ligase_aden; 2.
DR   Pfam; PF03120; DNA_ligase_OB; 1.
DR   PIRSF; PIRSF001604; LigA; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM00532; LIGANc; 1.
DR   SUPFAM; SSF52113; BRCT; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   SUPFAM; SSF47781; RuvA_2_like; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS01055; DNA_LIGASE_N1; FALSE_NEG.
DR   PROSITE; PS01056; DNA_LIGASE_N2; FALSE_NEG.
DR   HOGENOMDNA; DEPSY1_1.PE1006; -.
KW   NAD-dependent DNA ligase;
KW   Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;
KW   Magnesium; Manganese; Metal-binding; NAD; Zinc.
SQ   SEQUENCE   679 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLFCAGNPWL PAFFLQFVIM KKIDLTEKQR DLLVDVLDAE AGFAEEKLLD IASGAVSPLF
     LSESDLLSFL QAANALYRAG YPLLSDEAYD FTFLTELRRR NPQHPYLLQV EAEPVQQGKT
     VELPMRMLST DKAYDLESIR RWGRRIEKAA QEKGIDFTSL VFRGTPKLDG FAAYDDGRRL
     YTRGDGKKGT DVSRAFARGL QVSRGGSRGL GAGEIVVNKD YFTEHLAQFF DNSRNFQASL
     IKEKTLALPV VKAIEAGAAI FFPFSMLPDW RGSWLELLQE FEEIVEGLWQ KVPYEIDGVV
     FEIIDEGLRE VMGATRHHHR WQIAFKKNTE IAEVTVLRVR PQTSRLGRVN PVAEVEPTRL
     SGALIQRVTA HHYAMVRDRG IGPGARIRMS RSGEVIPKIE EVVKPVAAAQ LDIPAHCPSC
     GSDLAWDGDY LFCLNNMSCP AQITNSMEHF FKILGNVDGF GPSSVQRLYE GGLVDLPALY
     AMESADFEQV GFGPKQATNM VEQLNRSREE LIEDWRFLAA FGVHRLGMGN CEKLLRYVRL
     EDVFNLSEEQ IVAEIKGFQE KTAHSICAGL AGIKDLFFQL FALGFKLEPT PLLAEGGQGE
     KSPISGKTIV FTGAMLAASR GDMEKQAKAL GATVGKSITG KTDMLVTGQR VGATKMAKAE
     TLGIAILSEE AYRQLVSLD
//

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