(data stored in SCRATCH zone)

HOGENOM: ECOHS_1_PE1007

ID   ECOHS_1_PE1007                       STANDARD;      PRT;   172 AA.
AC   ECOHS_1_PE1007; A7ZYQ6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase;
DE   EC=4.2.1 60;AltName: Full=Beta-hydroxydecanoyl thioester dehydrase;
DE   (ECOHS_1.PE1007).
GN   Name=fabA; OrderedLocusNames=EcHS_A1063;
OS   ESCHERICHIA COLI HS.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331112;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ECOHS_1.PE1007.
CC       Escherichia coli HS, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:FABA_ECOHS
CC   -!- FUNCTION: Necessary for the introduction of cis unsaturation into
CC       fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl-
CC       ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-
CC       decenoyl-ACP (By similarity).
CC   -!- CATALYTIC ACTIVITY: (3R)-3-hydroxydecanoyl-[acyl-carrier-protein]
CC       = trans-dec-2-enoyl-[acyl-carrier-protein] + H(2)O.
CC   -!- CATALYTIC ACTIVITY: (3R)-3-hydroxydecanoyl-[acyl-carrier-protein]
CC       = cis-dec-3-enoyl-[acyl-carrier-protein] + H(2)O.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000277828 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A7ZYQ6; -.
DR   EMBL; CP000802; ABV05410.1; -; Genomic_DNA.
DR   RefSeq; YP_001457793.1; NC_009800.1.
DR   ProteinModelPortal; A7ZYQ6; -.
DR   SMR; A7ZYQ6; 2-172.
DR   STRING; A7ZYQ6; -.
DR   EnsemblBacteria; EBESCT00000052116; EBESCP00000050101; EBESCG00000051164.
DR   GeneID; 5591914; -.
DR   GenomeReviews; CP000802_GR; EcHS_A1063.
DR   KEGG; ecx:EcHS_A1063; -.
DR   eggNOG; COG0764; -.
DR   GeneTree; EBGT00050000010541; -.
DR   OMA; CHFKGDP; -.
DR   ProtClustDB; PRK05174; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00405; FabA; 1; -.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR010083; FabA.
DR   InterPro; IPR013114; FabA_FabZ.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF07977; FabA; 1.
DR   TIGRFAMs; TIGR01749; FabA; 1.
DR   HOGENOMDNA; ECOHS_1.PE1007; -.
KW   Complete proteome; Cytoplasm; Fatty acid biosynthesis;
KW   Lipid synthesis; Lyase.
SQ   SEQUENCE   172 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVDKRESYTK EDLLASGRGE LFGAKGPQLP APNMLMMDRV VKMTETGGNF DKGYVEAELD
     INPDLWFFGC HFIGDPVMPG CLGLDAMWQL VGFYLGWLGG EGKGRALGVG EVKFTGQVLP
     TAKKVTYRIH FKRIVNRRLI MGLADGEVLV DGRLIYTASD LKVGLFQDTS AF
//

If you have problems or comments...

PBIL Back to PBIL home page