(data stored in ACNUC7421 zone)

HOGENOM: ECOL5_1_PE101

ID   ECOL5_1_PE101                        STANDARD;      PRT;   347 AA.
AC   ECOL5_1_PE101; Q0TLN6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GMP reductase; EC=1.7.1 7;AltName: Full=Guanosine
DE   5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;
DE   (ECOL5_1.PE101).
GN   Name=guaC; OrderedLocusNames=ECP_0105;
OS   ESCHERICHIA COLI 536.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ECOL5_1.PE101.
CC       Escherichia coli 536, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:GUAC_ECOL5
CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination
CC       of GMP to IMP. It functions in the conversion of nucleobase,
CC       nucleoside and nucleotide derivatives of G to A nucleotides, and
CC       in maintaining the intracellular balance of A and G nucleotides
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) =
CC       guanosine 5'-phosphate + NADPH.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 1
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000165756 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q0TLN6; -.
DR   EMBL; CP000247; ABG68145.1; -; Genomic_DNA.
DR   RefSeq; YP_668044.1; NC_008253.1.
DR   ProteinModelPortal; Q0TLN6; -.
DR   SMR; Q0TLN6; 9-336.
DR   STRING; Q0TLN6; -.
DR   EnsemblBacteria; EBESCT00000048598; EBESCP00000046787; EBESCG00000047647.
DR   GeneID; 4189650; -.
DR   GenomeReviews; CP000247_GR; ECP_0105.
DR   KEGG; ecp:ECP_0105; -.
DR   eggNOG; COG0516; -.
DR   GeneTree; EBGT00050000009443; -.
DR   OMA; FRNSKQM; -.
DR   PhylomeDB; Q0TLN6; -.
DR   ProtClustDB; PRK05096; -.
DR   BioCyc; ECOL362663:ECP_0105-MON; -.
DR   GO; GO:0003920; F:GMP reductase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:InterPro.
DR   HAMAP; MF_00596; GMP_reduct_type1; 1; -.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005993; GMP_reduct1.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR11911:SF33; PTHR11911:SF33; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   PIRSF; PIRSF000235; GMP_reductase; 1.
DR   TIGRFAMs; TIGR01305; GMP_reduct_1; 1.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
DR   HOGENOMDNA; ECOL5_1.PE101; -.
KW   guanosine 5'-monophosphate oxidoreductase;
KW   Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium.
SQ   SEQUENCE   347 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQSWSGVPII AANMDTVGTF
     SMASALASFD ILTAVHKHYS VEEWQAFINN SSADVLKHVM VSTGTSDADF EKTKQILDLN
     PALNFVCIDV ANGYSEHFVQ FVAKAREAWP TKTICAGNVV TGEMCEELIL SGADIVKVGI
     GPGSVCTTRV KTGVGYPQLS AVIECADAAH GLGGMIVSDG GCTTPGDVAK AFGGGADFVM
     LGGMLAGHEE SGGRIVEENG EKFMLFYGMS SESAMKRHVG GVAEYRAAEG KTVKLPLRGP
     VENTARDILG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNNL
//

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