(data stored in SCRATCH3701 zone)

HOGENOM6: EHRRW_2_PE246

ID   EHRRW_2_PE246                        STANDARD;      PRT;   898 AA.
AC   EHRRW_2_PE246; Q5HBT5; Q5FE35;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (EHRRW_2.PE246).
GN   Name=gyrA; OrderedLocusNames=ERWE_CDS_02460, Erum2420;
OS   EHRLICHIA RUMINANTIUM STR. WELGEVONDEN.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=254945;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS EHRRW_2.PE246.
CC       Ehrlichia ruminantium str. Welgevonden, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q5HBT5_EHRRW
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5HBT5; Q5FE35; -.
DR   EMBL; CR767821; CAH57959.1; -; Genomic_DNA.
DR   EMBL; CR925678; CAI26740.1; -; Genomic_DNA.
DR   RefSeq; YP_180109.1; NC_005295.2.
DR   RefSeq; YP_197122.1; NC_006832.1.
DR   ProteinModelPortal; Q5HBT5; -.
DR   STRING; Q5HBT5; -.
DR   GeneID; 3233355; -.
DR   GeneID; 3260882; -.
DR   GenomeReviews; CR767821_GR; Erum2420.
DR   GenomeReviews; CR925678_GR; ERWE_CDS_02460.
DR   KEGG; eru:Erum2420; -.
DR   KEGG; erw:ERWE_CDS_02460; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   PhylomeDB; Q5HBT5; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; EHRRW_2.PE246; -.
DR   PRODOM; EHRRW_2_PE246.
DR   SWISS-2DPAGE; EHRRW_2_PE246.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   898 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSNLNNVIPV SIEQELEDSY LSYAMSVIVS RAIPDIRDGL KPVHRRILYS MYKSGYDYSK
     PYKKAARVVG DVMGKYHPHA DAAIYDSLVR MAQDFSLLLP LIDSQGNFGS IDGDPPASMR
     YTEARLARAA HFLLNDIDED TVDFRPNYDG NESEPVVLPA EFPNILVNGA GGVAVGMSTN
     IPSHNLGEVV DACIAYIDNP DITFDELIQI VHGPDFPTGG TILGDAGIRS AFMTGKGTII
     VQGKTHVEDL PSGKQAIIID EIPYQVNKAK LIERIHELVK EKRIEGILDL RDESNKMGIR
     VAIELKKQVS HQVVLNQILG LTPLRTSFSI NTLVLDNNKP KVMSLLDIIS TFIEYRKEVL
     TRRTQFRLRK VREKAHLYIG MYIAVLNIDQ VISIIRSSRD TAEATKRLLE CKWSALASVK
     EMIELVADSK SIVVNDVCQL TGVQVKSILE MKLQRLTSLE KEKLELDLKS MVSMIKQYTE
     LLGNKESLLK LVKNGLEEIK AKLAVPRKTT IDYSHFETDV EDLIPKEDMV VTVTMSGYIK
     RVKLSNYRAQ RRGGKGRIGQ AIREEDVITN LFVVNTHTSV LFFSNIGRVY KLKVYKLPLG
     DPTSRGRSLV NIFPLSENEV ITSVMPLPEN QEDTEQLNIL FATASGNLRR NALSDFQYVP
     SNGKIAMVLD EGDTLISVKV CTAENHVLIS TKLGKSIRFA VSNIRQFKGR ISDGVRAIRL
     SSEEDQVISM SVLIAMEVDS ETKDLYLKVP LEKRLLVKED GVINQGVANM LVDLGLSQDV
     FMSMVQNEEF ILTVTENGFG KRTSAYEYRT TLRGGVGVVN ILTTRRNGNV ISSFSVESND
     HIMLITNKGK LIRIAVNDIR IVGRSTQGVT LFKTDKQEKV VSVAKVIDHK DESDIDDV
//

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