(data stored in SCRATCH9089 zone)

HOGENOM6: ESCOL1_1_PE2969

ID   ESCOL1_1_PE2969                      STANDARD;      PRT;   752 AA.
AC   ESCOL1_1_PE2969; P0AFI2; O69154; P20082; Q2M9I1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA topoisomerase 4 subunit A; EC=5.99.1 -;AltName:
DE   Full=Topoisomerase IV subunit A; (ESCOL1_1.PE2969).
GN   Name=parC; OrderedLocusNames=b3019, JW2987;
OS   ESCHERICHIA COLI STR. K-12 SUBSTR. MG1655.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=511145;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ESCOL1_1.PE2969.
CC       Escherichia coli str. K-12 substr. MG1655 chromosome, complete genome.
CC       pEp5, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:PARC_ECOLI
CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome
CC       segregation. It relaxes supercoiled DNA. Performs the decatenation
CC       events required during the replication of a circular DNA molecule.
CC   -!- SUBUNIT: Composed of two subunits: ParC and ParE.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA24297.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000076277 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P0AFI2; O69154; P20082; Q2M9I1; -.
DR   EMBL; M58408; AAA24297.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M63491; AAA24396.1; -; Genomic_DNA.
DR   EMBL; U28377; AAA69187.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76055.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77075.1; -; Genomic_DNA.
DR   EMBL; L22025; AAC36840.1; -; Unassigned_DNA.
DR   PIR; A65089; A65089.
DR   RefSeq; AP_003569.1; AC_000091.1.
DR   RefSeq; NP_417491.1; NC_000913.2.
DR   PDB; 1ZVT; X-ray; 1.70 A; A/B=497-752.
DR   PDB; 1ZVU; X-ray; 3.00 A; A=27-742.
DR   PDBsum; 1ZVT; -.
DR   PDBsum; 1ZVU; -.
DR   ProteinModelPortal; P0AFI2; -.
DR   SMR; P0AFI2; 28-742.
DR   DIP; DIP-36030N; -.
DR   IntAct; P0AFI2; 23.
DR   MINT; MINT-1227290; -.
DR   PRIDE; P0AFI2; -.
DR   EnsemblBacteria; EBESCT00000000502; EBESCP00000000502; EBESCG00000000421.
DR   EnsemblBacteria; EBESCT00000015620; EBESCP00000014911; EBESCG00000014680.
DR   GeneID; 947499; -.
DR   GenomeReviews; AP009048_GR; JW2987.
DR   GenomeReviews; U00096_GR; b3019.
DR   KEGG; ecj:JW2987; -.
DR   KEGG; eco:b3019; -.
DR   EchoBASE; EB0680; -.
DR   EcoGene; EG10686; parC.
DR   eggNOG; COG0188; -.
DR   GeneTree; EBGT00050000010885; -.
DR   OMA; ILAITNE; -.
DR   ProtClustDB; PRK05561; -.
DR   BioCyc; EcoCyc:EG10686-MON; -.
DR   DrugBank; DB00817; Rosoxacin.
DR   Genevestigator; P0AFI2; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IDA:EcoliWiki.
DR   GO; GO:0009330; C:DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki.
DR   GO; GO:0019897; C:extrinsic to plasma membrane; IDA:EcoliWiki.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:RefGenome.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IDA:EcoliWiki.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IDA:EcoliWiki.
DR   GO; GO:0030541; P:plasmid partitioning; IDA:EcoliWiki.
DR   GO; GO:0007062; P:sister chromatid cohesion; IMP:EcoliWiki.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   InterPro; IPR005742; TopoIV_A_Gneg.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01062; ParC_Gneg; 1.
DR   HOGENOMDNA; ESCOL1_1.PE2969; -.
DR   PRODOM; ESCOL1_1_PE2969.
DR   SWISS-2DPAGE; ESCOL1_1_PE2969.
KW   3D-structure; Cell membrane; Complete proteome; DNA-binding;
KW   Isomerase; Membrane; Reference proteome; Topoisomerase.
SQ   SEQUENCE   752 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDMAERLAL HEFTENAYLN YSMYVIMDRA LPFIGDGLKP VQRRIVYAMS ELGLNASAKF
     KKSARTVGDV LGKYHPHGDS ACYEAMVLMA QPFSYRYPLV DGQGNWGAPD DPKSFAAMRY
     TESRLSKYSE LLLSELGQGT ADWVPNFDGT LQEPKMLPAR LPNILLNGTT GIAVGMATDI
     PPHNLREVAQ AAIALIDQPK TTLDQLLDIV QGPDYPTEAE IITSRAEIRK IYENGRGSVR
     MRAVWKKEDG AVVISALPHQ VSGARVLEQI AAQMRNKKLP MVDDLRDESD HENPTRLVIV
     PRSNRVDMDQ VMNHLFATTD LEKSYRINLN MIGLDGRPAV KNLLEILSEW LVFRRDTVRR
     RLNYRLEKVL KRLHILEGLL VAFLNIDEVI EIIRNEDEPK PALMSRFGLT ETQAEAILEL
     KLRHLAKLEE MKIRGEQSEL EKERDQLQGI LASERKMNNL LKKELQADAQ AYGDDRRSPL
     QEREEAKAMS EHDMLPSEPV TIVLSQMGWV RSAKGHDIDA PGLNYKAGDS FKAAVKGKSN
     QPVVFVDSTG RSYAIDPITL PSARGQGEPL TGKLTLPPGA TVDHMLMESD DQKLLMASDA
     GYGFVCTFND LVARNRAGKA LITLPENAHV MPPVVIEDAS DMLLAITQAG RMLMFPVSDL
     PQLSKGKGNK IINIPSAEAA RGEDGLAQLY VLPPQSTLTI HVGKRKIKLR PEELQKVTGE
     RGRRGTLMRG LQRIDRVEID SPRRASSGDS EE
//

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