(data stored in SCRATCH9089 zone)

HOGENOM6: ESCOL3_1_PE3882

ID   ESCOL3_1_PE3882                      STANDARD;      PRT;   752 AA.
AC   ESCOL3_1_PE3882; P0AFI3; O69154; P20082;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA topoisomerase 4 subunit A; EC=5.99.1 -;AltName:
DE   Full=Topoisomerase IV subunit A; (ESCOL3_1.PE3882).
GN   Name=parC; OrderedLocusNames=Z4373, ECs3903;
OS   ESCHERICHIA COLI O157:H7 STR. EDL933.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=155864;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ESCOL3_1.PE3882.
CC       Escherichia coli O157:H7 str. EDL933 chromosome, complete genome.
CC       pEp5, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:PARC_ECO57
CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome
CC       segregation. It relaxes supercoiled DNA. Performs the decatenation
CC       events required during the replication of a circular DNA molecule
CC       (By similarity).
CC   -!- SUBUNIT: Composed of two subunits: ParC and ParE (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076277 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P0AFI3; O69154; P20082; -.
DR   EMBL; AE005174; AAG58155.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37326.1; -; Genomic_DNA.
DR   PIR; G85961; G85961.
DR   PIR; G91116; G91116.
DR   RefSeq; NP_289596.1; NC_002655.2.
DR   RefSeq; NP_311930.1; NC_002695.1.
DR   ProteinModelPortal; P0AFI3; -.
DR   SMR; P0AFI3; 28-742.
DR   MINT; MINT-1227277; -.
DR   PRIDE; P0AFI3; -.
DR   EnsemblBacteria; EBESCT00000029064; EBESCP00000027957; EBESCG00000028114.
DR   EnsemblBacteria; EBESCT00000057190; EBESCP00000055018; EBESCG00000056238.
DR   GeneID; 916274; -.
DR   GeneID; 958400; -.
DR   GenomeReviews; AE005174_GR; Z4373.
DR   GenomeReviews; BA000007_GR; ECs3903.
DR   KEGG; ece:Z4373; -.
DR   KEGG; ecs:ECs3903; -.
DR   GeneTree; EBGT00050000010885; -.
DR   OMA; ILAITNE; -.
DR   ProtClustDB; PRK05561; -.
DR   BioCyc; ECOL83334:ECS3903-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   InterPro; IPR005742; TopoIV_A_Gneg.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01062; ParC_Gneg; 1.
DR   HOGENOMDNA; ESCOL3_1.PE3882; -.
DR   PRODOM; ESCOL3_1_PE3882.
DR   SWISS-2DPAGE; ESCOL3_1_PE3882.
KW   DNA topoisomerase IV subunit A;
KW   Cell membrane; Complete proteome; DNA-binding; Isomerase; Membrane;
KW   Topoisomerase.
SQ   SEQUENCE   752 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDMAERLAL HEFTENAYLN YSMYVIMDRA LPFIGDGLKP VQRRIVYAMS ELGLNASAKF
     KKSARTVGDV LGKYHPHGDS ACYEAMVLMA QPFSYRYPLV DGQGNWGAPD DPKSFAAMRY
     TESRLSKYSE LLLSELGQGT ADWVPNFDGT LQEPKMLPAR LPNILLNGTT GIAVGMATDI
     PPHNLREVAQ AAIALIDQPK TTLDQLLDIV QGPDYPTEAE IITSRAEIRK IYENGRGSVR
     MRAVWKKEDG AVVISALPHQ VSGARVLEQI AAQMRNKKLP MVDDLRDESD HENPTRLVIV
     PRSNRVDMDQ VMNHLFATTD LEKSYRINLN MIGLDGRPAV KNLLEILSEW LVFRRDTVRR
     RLNYRLEKVL KRLHILEGLL VAFLNIDEVI EIIRNEDEPK PALMSRFGLT ETQAEAILEL
     KLRHLAKLEE MKIRGEQSEL EKERDQLQGI LASERKMNNL LKKELQADAQ AYGDDRRSPL
     QEREEAKAMS EHDMLPSEPV TIVLSQMGWV RSAKGHDIDA PGLNYKAGDS FKAAVKGKSN
     QPVVFVDSTG RSYAIDPITL PSARGQGEPL TGKLTLPPGA TVDHMLMESD DQKLLMASDA
     GYGFVCTFND LVARNRAGKA LITLPENAHV MPPVVIEDAS DMLLAITQAG RMLMFPVSDL
     PQLSKGKGNK IINIPSAEAA RGEDGLAQLY VLPPQSTLTI HVGKRKIKLR PEELQKVTGE
     RGRRGTLMRG LQRIDRVEID SPRRASSGDS EE
//

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