(data stored in SCRATCH3701 zone)

HOGENOM6: FRAP2_2_PE1195

ID   FRAP2_2_PE1195                       STANDARD;      PRT;   864 AA.
AC   FRAP2_2_PE1195; B0TXG1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA topoisomerase (FRAP2_2.PE1195) (ATP-hydrolyzing);
DE   EC=5.99.1 3; .
GN   OrderedLocusNames=Fphi_1194;
OS   FRANCISELLA PHILOMIRAGIA SUBSP. PHILOMIRAGIA ATCC 25017.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=484022;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS FRAP2_2.PE1195.
CC       Francisella philomiragia subsp. philomiragia ATCC 25017, complete genom
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:B0TXG1_FRAP2
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B0TXG1; -.
DR   EMBL; CP000937; ABZ87419.1; -; Genomic_DNA.
DR   RefSeq; YP_001677920.1; NC_010336.1.
DR   ProteinModelPortal; B0TXG1; -.
DR   SMR; B0TXG1; 30-522, 536-842.
DR   STRING; B0TXG1; -.
DR   GeneID; 5908671; -.
DR   GenomeReviews; CP000937_GR; Fphi_1194.
DR   KEGG; fph:Fphi_1194; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; FRAP2_2.PE1195; -.
DR   PRODOM; FRAP2_2_PE1195.
DR   SWISS-2DPAGE; FRAP2_2_PE1195.
KW   DNA topoisomerase (ATP-hydrolyzing);
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   864 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSIPTKESSS INIEKELKQS YLDYAMSVII GRALPDVRDG LKPVHRRVLF AMNELSNYYN
     RPYKKSARVV GDVIGKYHPH GDTAVYDTIV RMAQPFSLRY TLVDGQGNFG SVDGDSPAAM
     RYTEIRMQKL THELLIDIDK ETVDFSPNYD NTELVPDVLP TRVPNLLING SSGIAVGMAT
     NIPPHNMTEV INGTMALIDN SQLTIEDLIQ YIPAPDFPTG SYINGTDGIL EAYKTGRGRV
     IMRAKVDIHE DEASGKSQIV ITEIPYQVNK AKLVEKIAEL VKDKKVTGIS ELRDESDKDG
     IRVVIDLKRD ESPEVVLNTL YAQTQLQCSF GINMVALSDN RPKLLNLKEI LEQFIKHRKE
     VVTRRTIFEL RKSKERAHIL EGLLLSLANI DEMIDLIKAS PSPAEAKESM LARSWNGSMV
     KSMLEGVDVK MYRKETLASH YGIQADSSYN LTEEQAEAIL ALRLHRLTGL EQDKITNEFK
     ELIERIKYLI GILSDVSELI RVVKEELVEI RDNYGDERKS EIIVSRLDLT REDLITEEDM
     VVTLSMDGYV KTQPLSMYNA QKRGGVGKSA TKTKEEDSIF KLMLASTHDT MLCFSSLGRV
     YWSKVYDFPV ASRISKGRPI NNILPLDKNE RITALMPISE FTEGWYVFMS TKLGRVKKVD
     LSEFARPRST GKIAIGLNDG DELSYVALTD GNKQIMMFSD AGKAIRFDES DVRAMGRSAA
     GVTGMRLHDN QKIVSVIVTN PDEGVVLAAT ENGYGKRTAV SEYRKTKRAS QGVIAISTSE
     RNGKVVVAVL VDNDEDIVMI TDNGTLVRTS SDQVRECGRS AQGVRLINLR NNEKLISLKV
     VKQEDEEAHD DQELESSEAT EQSE
//

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