(data stored in ACNUC7421 zone)

HOGENOM: FRASU_1_PE1002

ID   FRASU_1_PE1002                       STANDARD;      PRT;   330 AA.
AC   FRASU_1_PE1002; E3IYV2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ketol-acid reductoisomerase; EC=1.1.1 86;AltName:
DE   Full=Acetohydroxy-acid isomeroreductase;AltName:
DE   Full=Alpha-keto-beta-hydroxylacil reductoisomerase; (FRASU_1.PE1002).
GN   Name=ilvC; OrderedLocusNames=FraEuI1c_1017;
OS   FRANKIA SP. EUI1C.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Frankineae;
OC   Frankiaceae; Frankia.
OX   NCBI_TaxID=298654;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS FRASU_1.PE1002.
CC       Frankia sp. EuI1c chromosome, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:E3IYV2_FRASU
CC   -!- CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate +
CC       NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
CC   -!- CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
CC       = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 2/4.
CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
CC   -!- GENE_FAMILY: HOG000016230 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E3IYV2; -.
DR   EMBL; CP002299; ADP79090.1; -; Genomic_DNA.
DR   RefSeq; YP_004014960.1; NC_014666.1.
DR   ProteinModelPortal; E3IYV2; -.
DR   GeneID; 9971440; -.
DR   GenomeReviews; CP002299_GR; FraEuI1c_1017.
DR   KEGG; fri:FraEuI1c_1017; -.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00435; IlvC; 1; -.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR013023; AcH_isomrdctse.
DR   InterPro; IPR000506; AcH_isomrdctse_C.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013116; IlvN.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   PANTHER; PTHR21371; AcH_isomrdctse; 1.
DR   Pfam; PF01450; IlvC; 1.
DR   Pfam; PF07991; IlvN; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR   TIGRFAMs; TIGR00465; IlvC; 1.
DR   HOGENOMDNA; FRASU_1.PE1002; -.
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Isomerase; NADP; Oxidoreductase.
SQ   SEQUENCE   330 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVEIYYDDDA NLDDLTDRKV AIIGYGSQGH AHALNLRDSG VDVRVGLPET SKSRAKAQEE
     GLRVVTPFEA AAEADIIMIL APDTAHRKIY AESILPNLKA GDALAFGHGF NIRYNLISPP
     EGVDVFMIAP KGPGHLVRRV FQEGKGVPCL VAVETDATGK ALATALAYAK GIGGTRAGTL
     RTTFTEETET DLFGEQAVLC GGASALVQAG FETLVEAGYQ PEIAYFECLH ELKLIVDLMY
     EGGISQMRYS ISDTAEYGDV TRGPRVVTPA VKAEMRKILD EIQDGTFARE WVAEDDNGRP
     NFTKLVEEGK SHPIEKVGSK LRSMMSWIAK
//

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