(data stored in ACNUC7421 zone)

HOGENOM: FRATN_1_PE1003

ID   FRATN_1_PE1003                       STANDARD;      PRT;   171 AA.
AC   FRATN_1_PE1003; A0Q6P9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Crossover junction endodeoxyribonuclease ruvC; EC=3.1.22
DE   4;AltName: Full=Holliday junction nuclease ruvC;AltName: Full=Holliday
DE   junction resolvase ruvC; (FRATN_1.PE1003).
GN   Name=ruvC; OrderedLocusNames=FTN_1027;
OS   FRANCISELLA NOVICIDA U112.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS FRATN_1.PE1003.
CC       Francisella tularensis subsp. novicida U112, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:RUVC_FRATN
CC   -!- FUNCTION: Nuclease that resolves Holliday junction intermediates
CC       in genetic recombination. Cleaves the cruciform structure in
CC       supercoiled DNA by nicking to strands with the same polarity at
CC       sites symmetrically opposed at the junction in the homologous arms
CC       and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl
CC       group (By similarity).
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at a junction such as
CC       a reciprocal single-stranded crossover between two homologous DNA
CC       duplexes (Holliday junction).
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the ruvC family.
CC   -!- GENE_FAMILY: HOG000012181 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A0Q6P9; -.
DR   EMBL; CP000439; ABK89914.1; -; Genomic_DNA.
DR   RefSeq; YP_898668.1; NC_008601.1.
DR   ProteinModelPortal; A0Q6P9; -.
DR   SMR; A0Q6P9; 2-156.
DR   STRING; A0Q6P9; -.
DR   GeneID; 4548309; -.
DR   GenomeReviews; CP000439_GR; FTN_1027.
DR   KEGG; ftn:FTN_1027; -.
DR   eggNOG; COG0817; -.
DR   OMA; GCIRTGS; -.
DR   ProtClustDB; PRK00039; -.
DR   BioCyc; FTUL401614:FTN_1027-MON; -.
DR   GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   HAMAP; MF_00034; RuvC; 1; -.
DR   InterPro; IPR012337; RNaseH-like.
DR   InterPro; IPR020563; X-over_junc_endoDNase_Mg_BS.
DR   InterPro; IPR002176; X-over_junc_endoDNase_RuvC.
DR   Pfam; PF02075; RuvC; 1.
DR   PRINTS; PR00696; RSOLVASERUVC.
DR   SUPFAM; SSF53098; RNaseH_fold; 1.
DR   TIGRFAMs; TIGR00228; RuvC; 1.
DR   PROSITE; PS01321; RUVC; 1.
DR   HOGENOMDNA; FRATN_1.PE1003; -.
KW   Holliday junction resolvase;
KW   Complete proteome; DNA damage; DNA recombination; DNA repair;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease.
SQ   SEQUENCE   171 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVILGIDPGS RITGFGVIKV QDNKIYYVAS GCIRITEITT PKRLKQIADG ITQIINIYAP
     TEAAIEQIFM FQNPMGAIKL GQARGVAMCT LAINNLEVSE YSAKQIKQAV VGTGGAAKSQ
     VQHMVQSLLG LSKKPPEDAA DALAIAICHY HSSKSLAKIS GASRVSQKRI K
//

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