(data stored in SCRATCH3701 zone)

HOGENOM6: FRATO_1_PE441

ID   FRATO_1_PE441                        STANDARD;      PRT;   868 AA.
AC   FRATO_1_PE441; Q0BN26;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA topoisomerase (FRATO_1.PE441) (ATP-hydrolyzing);
DE   EC=5.99.1 3; .
GN   Name=gyrA; OrderedLocusNames=FTH_0535;
OS   FRANCISELLA TULARENSIS SUBSP. HOLARCTICA OSU18.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=393011;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS FRATO_1.PE441.
CC       Francisella tularensis subsp. holarctica OSU18, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:Q0BN26_FRATO
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q0BN26; -.
DR   EMBL; CP000437; ABI82508.1; -; Genomic_DNA.
DR   RefSeq; YP_763145.1; NC_008369.1.
DR   ProteinModelPortal; Q0BN26; -.
DR   SMR; Q0BN26; 30-522, 536-842.
DR   STRING; Q0BN26; -.
DR   GeneID; 4307944; -.
DR   GenomeReviews; CP000437_GR; FTH_0535.
DR   KEGG; fth:FTH_0535; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; FRATO_1.PE441; -.
DR   PRODOM; FRATO_1_PE441.
DR   SWISS-2DPAGE; FRATO_1_PE441.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   868 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSIITKESSS INIEKELKQS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMNELSNYYN
     RPYKKSARVV GDVIGKYHPH GDTAVYDTIV RMAQPFSLRY TLVDGQGNFG SVDGDSPAAM
     RYTEIRMEKL THELLIDIDK ETVDFSPNYD NTELVPDVLP TRVPNLLVNG SSGIAVGMAT
     NIPPHNMTEV INGTIALIDN PNLTIEELIE YIPAPDFPTG SYINGTDGIL EAYKTGRGRV
     IMRAKADIHE DEASGKAQII VTEIPYQVNK AKLVEKIAEL VKDKKVAGIS ELRDESDKDG
     IRVVIDLKRD ESPEVVLNTL YAQTQLQCSF GINMVALSDN RPKLLNLKEI LEQFIKHRKE
     VVTRRTIFEL RKSKERAHIL EGLLLSLANI DEMIELIKAS PSPADAKESM LARSWNGSMV
     KSMLEGVDVK MYRKETLASY YGIQVDSSYN LTEEQADAIL ALRLHRLTGL EQDKIVNEFK
     ELIDRIKYLI SILSDIKELI CVVKDELVEI RDNYGDQRKS EIIESRLDLT REDLIAEEDM
     VVTLSMDGYV KTQPLSMYNA QKRGGVGKSA TKTKEEDSIF KLMLASTHDT MLCFSSLGRV
     YWSKVYDFPV ASRISKGRPI NNILPLEKDE RITAMMPISQ FNEGWYVFMA TKLGRVKKVD
     LSEFARPRST GKIAIGLNDG DELSYVALTD GNKQIMMFSD AGKAIRFDES DVRAMGRSAA
     GVTGMRLHHN QKIVSVIVTN PDEGIVLAAT ENGYGKRTAV SEYRKTKRAS QGVIAISTSE
     RNGKVVVAVL VENDEDIVMI TDNGTLVRTS SDEVRECGRS AQGVRLINLR NNEKLISLKV
     VKQDDVEDNQ DIENNEDIES SDVTVQSE
//

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