(data stored in SCRATCH zone)

HOGENOM: HAEPS_1_PE10

ID   HAEPS_1_PE10                         STANDARD;      PRT;   675 AA.
AC   HAEPS_1_PE10; B8F314;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA ligase; EC=6.5.1 2;AltName:
DE   Full=Polydeoxyribonucleotide synthase (HAEPS_1.PE10) [NAD+]; .
GN   Name=ligA; OrderedLocusNames=HAPS_0011;
OS   HAEMOPHILUS PARASUIS SH0165.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=557723;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HAEPS_1.PE10.
CC       Haemophilus parasuis SH0165, complete genome.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:DNLJ_HAEPS
CC   -!- FUNCTION: DNA ligase that catalyzes the formation of
CC       phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl
CC       groups in double-stranded DNA using NAD as a coenzyme and as the
CC       energy source for the reaction. It is essential for DNA
CC       replication and repair of damaged DNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 BRCT domain.
CC   -!- GENE_FAMILY: HOG000218458 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B8F314; -.
DR   EMBL; CP001321; ACL31716.1; -; Genomic_DNA.
DR   RefSeq; YP_002474664.1; NC_011852.1.
DR   ProteinModelPortal; B8F314; -.
DR   STRING; B8F314; -.
DR   GeneID; 7278626; -.
DR   GenomeReviews; CP001321_GR; HAPS_0011.
DR   KEGG; hap:HAPS_0011; -.
DR   OMA; ENVRTIR; -.
DR   ProtClustDB; PRK07956; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003911; F:DNA ligase (NAD+) activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01588; DNA_ligase_A; 1; -.
DR   InterPro; IPR001357; BRCT.
DR   InterPro; IPR018239; DNA_ligase_AS.
DR   InterPro; IPR004150; DNA_ligase_OB.
DR   InterPro; IPR001679; DNAligase.
DR   InterPro; IPR013839; DNAligase_adenylation.
DR   InterPro; IPR013840; DNAligase_N.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004149; Znf_DNAligase_C4.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF01653; DNA_ligase_aden; 1.
DR   Pfam; PF03120; DNA_ligase_OB; 1.
DR   Pfam; PF03119; DNA_ligase_ZBD; 1.
DR   PIRSF; PIRSF001604; LigA; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM00278; HhH1; 4.
DR   SMART; SM00532; LIGANc; 1.
DR   SUPFAM; SSF52113; BRCT; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   SUPFAM; SSF47781; RuvA_2_like; 1.
DR   TIGRFAMs; TIGR00575; Dnlj; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS01055; DNA_LIGASE_N1; 1.
DR   PROSITE; PS01056; DNA_LIGASE_N2; 1.
DR   HOGENOMDNA; HAEPS_1.PE10; -.
KW   NAD-dependent DNA ligase LigA;
KW   Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;
KW   Magnesium; Manganese; Metal-binding; NAD; Zinc.
SQ   SEQUENCE   675 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPHSIETQLE HLREKLREYE YHYHVLDNPL VPDAEYDRLM NELKNLEWQH PELITSDSPT
     QRVGAKPLDG FAQITHEIPM LSLDNAFSDD DLTGFLRRIE DRIAINSNQI EFCCEPKLDG
     LAVSILYVDG VLTQAATRGD GTTGEDITAN IRTIRNIPLK LKTNNPPHRL EVRGEVFMPQ
     QGFEQLNEKA LAKGEKTFAN PRNAAAGSLR QLDPKITSQR PLMLNAYNIG VYESDDELPT
     THFDRLQWLK TLGIPVNAEI TLATGSQALT AFYQKIQAKR SSLGYDIDGT VLKVNEITLQ
     EQLGFISKAP RWAIAYKFPA QEEMTILNDV EFQVGRTGAI TPVAKLEPVF VAGVTVSNAT
     LHNGDEIERL GIAIGDTVII RRAGDVIPQI VGVVAERRPD NAKKIAFPTA CPVCNSAVVR
     VEGEAVARCT GGLFCGAQRK EALKHFVSRK AMDIDGVGEK LIEQLMEREL IHTPADLFKL
     DHTTLMRLDR MGEKSANNAL QSIEKAKNTT LARFLFALGI RDVGESTAQN LANHFGTLDA
     IRQADLDTLK QVQDVGEVVA NRLFQFWQEP HNVEVVEDLI AQGVTWQDVV PQEIADNPLK
     DKTVVLTGTL TQLTRDQAKA LLQQLGCKVS GSVSSKTDYL IAGEKAGSKL AKAQELGVKI
     LSEDELIGYF TTIVS
//

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