(data stored in ACNUC7421 zone)

HOGENOM: HAINF3_1_PE1005

ID   HAINF3_1_PE1005                      STANDARD;      PRT;   418 AA.
AC   HAINF3_1_PE1005; E7AG43;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=tRNA-specific 2-thiouridylase mnmA; EC=2.8.1 -;
DE   (HAINF3_1.PE1005).
GN   Name=mnmA; ORFNames=HICON_13010;
OS   HAEMOPHILUS INFLUENZAE F3047.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=935897;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HAINF3_1.PE1005.
CC       Haemophilus influenzae F3047, complete genome.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:E7AG43_HAEIF
CC   -!- FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble
CC       position (U34) of tRNA, leading to the formation of s(2)U34 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the mnmA/TRMU family.
CC   -!- GENE_FAMILY: HOG000218046 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E7AG43; -.
DR   EMBL; FQ670204; CBY86764.1; -; Genomic_DNA.
DR   RefSeq; YP_004138444.1; NC_014922.1.
DR   GeneID; 10111653; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00144; tRNA_thiouridyl_MnmA; 1; -.
DR   InterPro; IPR023382; Adenine_a_hdrlase_dom.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR004506; tRNA-specific_2-thiouridylase.
DR   Gene3D; G3DSA:2.30.30.280; G3DSA:2.30.30.280; 1.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   PANTHER; PTHR11933; TrmU_mtfrase; 1.
DR   Pfam; PF03054; tRNA_Me_trans; 1.
DR   TIGRFAMs; TIGR00420; TrmU; 1.
DR   HOGENOMDNA; HAINF3_1.PE1005; -.
KW   ATP-binding; Cytoplasm; Disulfide bond; Methyltransferase;
KW   Nucleotide-binding; RNA-binding; Transferase; tRNA processing;
KW   tRNA-binding.
SQ   SEQUENCE   418 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTALYVQNKI NGKIILPFSH SMTNVLRLNR SYGRTMLISN TYNQHFPQLT QEQLASNATK
     KVICGMSGGV DSSVSAFILQ QQGYQVEGLF MKNWEEDDDT DYCTAAADLA DAQAVCDKLG
     IKLHKINFAA EYWDNVFEHF LTEYKAGRTP NPDILCNKEI KFKAFLEYAA EDLGADYIAT
     GHYVRRAGDD ENAKLLRGLD ANKDQSYFLY TLSHKQVGQS LFPVGKIEKP IVRAIAEDLG
     LITAKKKDST GICFIGERKF KDFLARYLPA QPGNIRTVDN EIIGRHDGLM YHTLGQRKGL
     GIGGLKNAGD EAWYVVDKDV KNNELIVAQG HDHPRLFSKG LIASQLHWVD RQPIRELLRC
     TVKTRYRQQD ISCAIEPIDD ETIRVIFDEP QSAVTPGQSA VFYLGEVCLG GGIIAERI
//

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