(data stored in SCRATCH3701 zone)

HOGENOM6: HELP3_1_PE897

ID   HELP3_1_PE897                        STANDARD;      PRT;   826 AA.
AC   HELP3_1_PE897; D7FE52;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, subunit A; EC=5.99.1 3; (HELP3_1.PE897).
GN   Name=gyrA; OrderedLocusNames=HPB8_902;
OS   HELICOBACTER PYLORI B8.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=693745;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HELP3_1.PE897.
CC       Helicobacter pylori B8, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:D7FE52_HELP3
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D7FE52; -.
DR   EMBL; FN598874; CBI66459.1; -; Genomic_DNA.
DR   RefSeq; YP_003728923.1; NC_014256.1.
DR   GeneID; 9349667; -.
DR   GenomeReviews; FN598874_GR; HPB8_902.
DR   KEGG; hpl:HPB8_902; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; HELP3_1.PE897; -.
DR   PRODOM; HELP3_1_PE897.
DR   SWISS-2DPAGE; HELP3_1_PE897.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   826 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQDNLINETK NIVEVGIDSS IEESYLAYSM SVIIGRALPD ARDGLKPVHR RILYAMHELG
     LTSKVAYKKS ARIVGDVIGK YHPHGDNAVY DALVRMAQDF SMRLELVDGQ GNFGSIDGDN
     AAAMRYTEAR MTKASEEILR DIDKDTIDFV PNYDDTLKEP DILPSRLPNL LVNGANGIAV
     GMATSIPPHR MDEIIDALMH VLENPNAALD EILEFVKGPD FPTGGIIYGK AGIIEAYKTG
     RGRVKVRAKV HVEKTKNKEI IVLDEMPFQT NKAKLVEQIS DLAREKQIEG ISEVRDESDR
     EGIRVVIELK RDAISEIVLN HLYKLTTMET TFSIILLAIY NKEPKIFTLL ELLRLFLNHR
     KTIIIRRTIF ELEKAKARAH ILEGYLIALD NIDEIVQLIK TSPSPEAAKN ALMERFSLSE
     IQSKAILEMR LQRLTGLERD KIKEEYQNLL ELIDDLNGIL KSEDRLNGVV KTELLEVKEQ
     FSSPRRTEIQ ESYESIDIED LIANEPMVVS MSYKGYVKRV DLKAYEKQNR GGKGKLSGST
     YEDDFIENFF VANTHDILLF ITNKGQLYHL KVYKIPEASR IAMGKAIVNL ISLAPDEKIM
     ATLSTKDFSD ERSLAFFTKN GVVKRTNLSE FGGNRSYSGI RAIVLDKGDE LVGAKVVDNN
     AKHLLIASHL GIFIKFPLED VREIGRTTRG VRGIKLNEND FVVGAVVISD DSNKLLSVSE
     NGLGKQTLAE AYREQSRGGK GVIGMKLTQK TGNLVGVISV DDENLDLMIL TASAKMIRVS
     IKDIRETGRN ASGVKLINTA DKVMYVNSCP KEEEPENLEN SPAKFV
//

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