(data stored in SCRATCH3701 zone)

HOGENOM6: HELPS_1_PE640

ID   HELPS_1_PE640                        STANDARD;      PRT;   826 AA.
AC   HELPS_1_PE640; B2UTC7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; (HELPS_1.PE640).
GN   OrderedLocusNames=HPSH_03350;
OS   HELICOBACTER PYLORI SHI470.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=512562;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HELPS_1.PE640.
CC       Helicobacter pylori Shi470, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:B2UTC7_HELPS
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B2UTC7; -.
DR   EMBL; CP001072; ACD48109.1; -; Genomic_DNA.
DR   RefSeq; YP_001910139.1; NC_010698.2.
DR   STRING; B2UTC7; -.
DR   GeneID; 6296014; -.
DR   GenomeReviews; CP001072_GR; HPSH_03350.
DR   KEGG; hps:HPSH_03350; -.
DR   OMA; TSIPPHR; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; HELPS_1.PE640; -.
DR   PRODOM; HELPS_1_PE640.
DR   SWISS-2DPAGE; HELPS_1_PE640.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   826 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQDNLINETK NIVEVGIDSS IEESYLAYSM SVIIGRALPD ARDGLKPVHR RILYAMHELG
     LTSKVAYKKS ARIVGDVIGK YHPHGDNAVY DALVRMAQDF SMRLELVDGQ GNFGSIDGDN
     AAAMRYTEAR MTKASEEILR DIDKDTIDFV PNYDDTLKEP DILPSRLPNL LVNGANGIAV
     GMATSIPPHR IDEIIDALVH VLENPNAGLD EILEFVKGPD FPTGGIIYGK AGIIEAYKTG
     RGRVKVRAKV HVEKTKNKEI IVLDEMPFQT NKAKLVEQIS DLAREKQIEG ISEVRDESDR
     EGIRVVIELK RDAMSEIVLN HLYKLTTMET TFSIILLAIY NKEPKIFTLL ELLRLFLNHR
     KTIIIRRTIF ELEKAKARAH ILEGYLIALD NIDEIVRLIK TSQSPEAAKD ALMERFTLSE
     IQSKAILEMR LQRLTGLERD KIKEEYQNLL ELISDLNGIL KSEDRLNEVV KTELLEVKEQ
     FSSQRCTEIQ EVYENIDIED LIANEPMVVS MSYKGYVKRV DLKAYERQNR GGKGKLSGNT
     YEDDFIENFF VANTHDILLF ITNKGQLYRL KVYKIPEASR IAMGKAIVNL ISLAPDEKIM
     ATLSTKDFSD ERSLAFFTKK GVVKRTNLSE FDSNYNGMRA IVLDEGDELV SAKIVDKNAK
     HLLIASYLGI FIKFSLEDVR EIGRTTRGVR GIRLNENDFV VGAVVISDDS NKLLSVSENG
     LGKQTLAEAY REQSRGGKGI IGMKLTQKTG NLVSVISVDD ENLDLMILTA SAKMIRVSIQ
     DIKETIGRNT SGVKLIDTAD KVVYANSCPK EEEPENSENP PTQLFE
//

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