(data stored in ACNUC19913 zone)

HOGENOM: HORSE18_4_PE10

ID   HORSE18_4_PE10                       STANDARD;      PRT;   459 AA.
AC   HORSE18_4_PE10; Q28380;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Vitamin K-dependent protein C; EC=3.4.21 69;AltName:
DE   Full=Anticoagulant protein C;AltName: Full=Autoprothrombin IIA;AltName:
DE   Full=Blood coagulation factor XIV;Flags: Fragment; (HORSE18_4.PE10).
GN   Name=PROC;
OS   EQUUS CABALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HORSE18_4.PE10.
CC       Equus caballus chromosome 18 EquCab2 partial sequence 2994767..3994766
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PROC_HORSE
CC   -!- FUNCTION: Protein C is a vitamin K-dependent serine protease that
CC       regulates blood coagulation by inactivating factors Va and VIIIa
CC       in the presence of calcium ions and phospholipids.
CC   -!- CATALYTIC ACTIVITY: Degradation of blood coagulation factors Va
CC       and VIIIa.
CC   -!- TISSUE SPECIFICITY: Plasma; synthesized in the liver.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
CC   -!- GENE_FAMILY: HOG000251821 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Equus_caballus;ENSECAG00000016570;ENSECAT00000017498;ENSECAP00000014224.
DR   EMBL; D43753; - ;
DR   UniProtKB/Swiss-Prot; Q28380; -.
DR   EMBL; D43753; BAA07810.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q28380; -.
DR   SMR; Q28380; 1-157.
DR   STRING; Q28380; -.
DR   MEROPS; S01.218; -.
DR   GeneTree; ENSGT00560000076714; -.
DR   InParanoid; Q28380; -.
DR   OrthoDB; EOG43BMNX; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR009003; Pept_cys/ser_Trypsin-like.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Pept_Ser_Cys; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; PARTIAL.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
DR   HOGENOMDNA; HORSE18_4.PE10; -.
KW   ENSECAG000000165705old_1320000031; ENSECAP000000142241old_1320000031;
KW   D43753;
KW   Blood coagulation; Complete proteome; Disulfide bond; Glycoprotein;
KW   Hydrolase; Protease; Serine protease.
SQ   SEQUENCE   459 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MWQIASLLLF TTIWGISGIP APPDSVFASS ERAHQVLRIR KRANSFLEEL RDGNLERECR
     EEVCDFEEAQ EIFQNLDDTL AFWSKHYDGD QCEAPPPEHP CDSPPISERN PPSSGLGGSG
     LASSRSEQGG EGELALWFTL CREYTCGLLQ GFCVLSRPSH LPCPPAVQLL EFCTHQLPLL
     SVMFPCGRPG KRTEKRRKNL KRDTEQADQI DPRLVNGQLT GWGDSPWQVI LLDSKRKLAC
     GAVLIHTSWV LTAAHCMEDS KKLIVRLGEY DLRRRENGEV DLDIQEVIMH PNYSKSSSDN
     DIALLRLARP ATFSQTIVPI CLPDSGLSER ELTQAGQETV VTGWGYRSET KRNRTFVLNF
     IKVPVVPHSE CVRTMHNLVS ENMLCAGILG DTRDACEGDS GGPMVASFRG TWFLVGLVSW
     GEGCGRLHNY GVYTKVSRYL DWIHGHIRAA EASLKSQVP
//

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