(data stored in ACNUC17492 zone)

HOGENOM: HORSE30_23_PE3

ID   HORSE30_23_PE3                       STANDARD;      PRT;   196 AA.
AC   HORSE30_23_PE3; Q6RG78;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 1; Short=RGS1;
DE   (HORSE30_23.PE3).
GN   Name=RGS1;
OS   EQUUS CABALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HORSE30_23.PE3.
CC       Equus caballus chromosome 30 EquCab2 partial sequence 20771313..2165729
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS1_HORSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. This protein may be involved in the
CC       regulation of B-cell activation and proliferation (By similarity).
CC   -!- PTM: Could be phosphorylated. Might be functionally regulated by
CC       protein kinase(s) (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Equus_caballus;ENSECAG00000004942;ENSECAT00000005582;ENSECAP00000003936.
DR   EMBL; AY499344; - ;
DR   UniProtKB/Swiss-Prot; Q6RG78; -.
DR   EMBL; AY499344; AAR91750.1; -; mRNA.
DR   RefSeq; NP_001075408.1; NM_001081939.1.
DR   UniGene; Eca.588; -.
DR   ProteinModelPortal; Q6RG78; -.
DR   SMR; Q6RG78; 58-191.
DR   Ensembl; ENSECAT00000005582; ENSECAP00000003936; ENSECAG00000004942.
DR   GeneID; 100034151; -.
DR   KEGG; ecb:100034151; -.
DR   CTD; 5996; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q6RG78; -.
DR   OMA; KIYKAFV; -.
DR   OrthoDB; EOG42822Z; -.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HORSE30_23.PE3; -.
KW   ENSECAG000000049425old_1320000031; ENSECAP000000039361old_1320000031;
KW   AY499344;
KW   B-cell activation; Complete proteome; Phosphoprotein;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   196 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPGMFFSANP KDLKGTDQSL LDDKTQKRRP KTFGMDVKAY LRSMIPHLES GMKSSKSKDI
     LSADEVMQWS QSLEKLLANQ TGQDVFGNFL KSEFSEENIE FWLACEDYKK TESDLLRCKA
     EKIYKAFVHS DAAKQINIDF HTRESTAKKI KAPTLTCFDE AQKVIYTLME KDSYPRFLKS
     NIYLNLLNDL QANSLK
//

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