(data stored in ACNUC27670 zone)

HOGENOM: HORSE5_45_PE20

ID   HORSE5_45_PE20                       STANDARD;      PRT;   92 AA.
AC   HORSE5_45_PE20; O77691;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A6;AltName: Full=Calcyclin;AltName: Full=S100
DE   calcium-binding protein A6; (HORSE5_45.PE20).
GN   Name=S100A6; Synonyms=CACY;
OS   EQUUS CABALLUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HORSE5_45.PE20.
CC       Equus caballus chromosome 5 EquCab2 partial sequence 43645312..44645311
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A6_HORSE
CC   -!- FUNCTION: May function as calcium sensor and contribute to
CC       cellular calcium signaling (Potential). May function by
CC       interacting with other proteins and indirectly play a role in the
CC       reorganization of the actin cytoskeleton and in cell motility.
CC       Binds 2 calcium ions. Calcium binding is cooperative (By
CC       similarity). Interacts with FKBP4 (By similarity).
CC   -!- SUBUNIT: Homodimer; head to tail assembly of 2 subunits. Interacts
CC       with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1 and
CC       CACYBP. Interacts with TP53. Interacts with tropomyosin (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope (By similarity). Cytoplasm
CC       (By similarity). Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Equus_caballus;ENSECAG00000008401;ENSECAT00000008544;ENSECAP00000006408.
DR   EMBL; AF083065; - ;
DR   UniProtKB/Swiss-Prot; O77691; -.
DR   EMBL; AF083065; AAC33290.1; -; mRNA.
DR   RefSeq; NP_001075310.1; NM_001081841.1.
DR   UniGene; Eca.212; -.
DR   ProteinModelPortal; O77691; -.
DR   SMR; O77691; 2-90.
DR   Ensembl; ENSECAT00000008544; ENSECAP00000006408; ENSECAG00000008401.
DR   GeneID; 100033887; -.
DR   KEGG; ecb:100033887; -.
DR   CTD; 6277; -.
DR   GeneTree; ENSGT00600000084162; -.
DR   InParanoid; O77691; -.
DR   OMA; VVNFQEY; -.
DR   OrthoDB; EOG4MSD0W; -.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; HORSE5_45.PE20; -.
KW   ENSECAG000000084015old_1320000031; ENSECAP000000064081old_1320000031;
KW   AF083065;
KW   Acetylation; Calcium; Cell membrane; Complete proteome; Cytoplasm;
KW   Membrane; Metal-binding; Nucleus; Repeat.
SQ   SEQUENCE   92 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MACPLDQAIS LLVAIFHKYS SREGDKNTLS KGELKELIQK ELTIGAELED SEIAKLLDDL
     DQNKDQVVNF QEYVTFLGAL AMIYNEVLKA CS
//

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