(data stored in ACNUC11016 zone)

HOGENOM: HS10_PE1001

ID   HS10_PE1001                          STANDARD;      PRT;   658 AA.
AC   HS10_PE1001; Q5T2P9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing
DE   protein 10; Short=AGAP-10;AltName: Full=Centaurin-gamma-like family
DE   member 7; (HS10.PE1001).
GN   Name=AGAP10; Synonyms=CTGLF7;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE1001.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AGA10_HUMAN
CC   -!- FUNCTION: Putative GTPase-activating protein (Potential).
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of centaurin
CC       gamma-like genes clustered in the q11 region of chromosome 10.
CC   -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC   -!- SIMILARITY: Contains 1 ANK repeat.
CC   -!- SIMILARITY: Contains 1 Arf-GAP domain.
CC   -!- SIMILARITY: Contains 1 PH domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI12206.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000007233 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000204172;ENST00000452145;ENSP00000392206.
DR   EMBL; AL391137; - ;
DR   UniProtKB/Swiss-Prot; Q5T2P9; -.
DR   EMBL; AL391137; CAI12206.1; ALT_SEQ; Genomic_DNA.
DR   IPI; IPI00939972; -.
DR   UniGene; Hs.712688; -.
DR   ProteinModelPortal; Q5T2P9; -.
DR   SMR; Q5T2P9; 280-447, 465-657.
DR   PRIDE; Q5T2P9; -.
DR   Ensembl; ENST00000452145; ENSP00000392206; ENSG00000204172.
DR   GeneCards; GC10M047191; -.
DR   HGNC; HGNC:23462; AGAP10.
DR   neXtProt; NX_Q5T2P9; -.
DR   eggNOG; KOG0705; -.
DR   GeneTree; ENSGT00600000084361; -.
DR   InParanoid; Q5T2P9; -.
DR   ArrayExpress; Q5T2P9; -.
DR   CleanEx; HS_AGAP10; -.
DR   Genevestigator; Q5T2P9; -.
DR   GO; GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR001164; ArfGAP.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   Gene3D; G3DSA:1.25.40.20; ANK; 1.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 2.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF57863; ArfGAP; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; FALSE_NEG.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; HS10.PE1001; -.
KW   ENSG000002041721755old_1320000031; ENSP000003922067901old_1320000031;
KW   AL391137;
KW   ANK repeat; Complete proteome; GTPase activation; Metal-binding;
KW   Reference proteome; Zinc; Zinc-finger.
SQ   SEQUENCE   658 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ PAEVTVEVGE
     DLHMHQVRDR EMPEALEFNL SANPEASTIF QRNSQTDALE FNSSANPEAS TIFQRNSQTD
     VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTAIQHYL TMTIISVTLE IPHHITQRDA
     DRSLSIPDEQ LHSFAVSTVH IMKKRNGGGS LNNYSSSIPP TPSTSQEDPQ FSVPPTANTP
     TPVCKLSMRW SNLFTSEKGS DPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
     KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS
     NGLSKDMDTG LGDSICFSPG ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT
     WHFEATTYEE RDAWVQAIQS QILASLQSCK SSKSKSQLTS QSEAMALQSI QNMRGNAHCV
     DCETQNPKWA SLNLGVLMCI ECSGIHRSFG TRLSRVRSLE LDDWPVELRK VMSSIGNELA
     NSIWEGSSQG QTKPSIKSTR EEKEWWIRSK YEEKLFLAPL PCTELSLGQQ LLRATTDEDL
     QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLE QLLTGWTSWP EMPTGTQR
//

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