(data stored in ACNUC27125 zone)

HOGENOM: HS10_PE1009

ID   HS10_PE1009                          STANDARD;      PRT;   1253 AA.
AC   HS10_PE1009; Q5SNT6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=WASH complex subunit FAM21B; (HS10.PE1009).
GN   Name=FAM21B;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE1009.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:FA21B_HUMAN
CC   -!- FUNCTION: Component of the WASH complex, a complex present at the
CC       surface of endosomes that recruits and activates the Arp2/3
CC       complex to induce actin polymerization. The WASH complex plays a
CC       key role in the fission of tubules that serve as transport
CC       intermediates during endosome sorting. In the complex, it probably
CC       mediates the recruitment of the complex to endosome membranes (By
CC       similarity).
CC   -!- SUBUNIT: Component of the WASH complex, composed of F-actin-
CC       capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-
CC       capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P,
CC       WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C),
CC       KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with
CC       WASH1; the interaction is direct (By similarity).
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane (By similarity).
CC   -!- MISCELLANEOUS: In human, FAM21 has undergone evolutionary
CC       duplication, with 4 highly homologous family members existing,
CC       including FAM21A, FAM21B, FAM21C, and an N-terminally truncated
CC       FAM21D form.
CC   -!- SIMILARITY: Belongs to the FAM21 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI17187.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000112469 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000152726;ENST00000358474;ENSP00000351259.
DR   EMBL; AL954360; - ;
DR   EMBL; BC065500; - ;
DR   UniProtKB/Swiss-Prot; Q5SNT6; -.
DR   EMBL; AL954360; CAI17187.1; ALT_SEQ; Genomic_DNA.
DR   IPI; IPI00884375; -.
DR   RefSeq; NP_060702.1; NM_018232.1.
DR   UniGene; Hs.365286; -.
DR   UniGene; Hs.449662; -.
DR   ProteinModelPortal; Q5SNT6; -.
DR   IntAct; Q5SNT6; 2.
DR   STRING; Q5SNT6; -.
DR   PhosphoSite; Q5SNT6; -.
DR   PRIDE; Q5SNT6; -.
DR   Ensembl; ENST00000358474; ENSP00000351259; ENSG00000152726.
DR   GeneID; 55747; -.
DR   KEGG; hsa:55747; -.
DR   UCSC; uc001jep.2; human.
DR   CTD; 55747; -.
DR   GeneCards; GC10P045861; -.
DR   H-InvDB; HIX0025987; -.
DR   HGNC; HGNC:23417; FAM21B.
DR   neXtProt; NX_Q5SNT6; -.
DR   PharmGKB; PA134877872; -.
DR   InParanoid; Q5SNT6; -.
DR   NextBio; 60723; -.
DR   Bgee; Q5SNT6; -.
DR   CleanEx; HS_FAM21B; -.
DR   Genevestigator; Q5SNT6; -.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071203; C:WASH complex; ISS:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR   HOGENOMDNA; HS10.PE1009; -.
KW   ENSG000001527261755old_1320000031; ENSP000003512597901old_1320000031;
KW   Q5SNT8_HUMAN; Q6P0Q7_HUMAN; AL954360; BC065500;
KW   Complete proteome; Endosome; Membrane; Phosphoprotein;
KW   Reference proteome; Transport.
SQ   SEQUENCE   1253 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN YGLQVLDSAF
     EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI GSKLFMEQED VGLGELSSEE
     GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE
     EEDIEDIEEN TRPKRSRPTS FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE
     RRTPSDDEED NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG
     ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP RKSPYGPPPT
     GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG DLFKEKAVAS PEATVSQTDE
     NKARAEKKVT LSSSKNLKPS SETKTQKGLF SDEEDSEDLF SSQSASKLKG ASLLPGKLPT
     SVSLFDDEDE EDNLFGGTAA KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI
     PASQTHLASD SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS
     LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG VKSVDKKVES
     AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP WDKGTKPRTK TVLSLFDEEE
     DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG VFQDEELLFS HKLQKDNDPD VDLFAGTKKT
     KLLEPSVGSL FGDDEDDDLF SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK
     GIWKPETPQD SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF
     PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR RPQTRAARRL
     AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG EDSTEEALAA AAAPWEGGPV
     PGVDRSPFAK SLGHSRGEAD LFDSGDIFST GTGSQSVERT KPKAKIAENP ANPPVGGKAK
     SPMFPALGEA SSDDDLFQSA KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI
     LTTQDIFEDD IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK
     SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF GGQ
//

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