(data stored in ACNUC27125 zone)

HOGENOM: HS10_PE1011

ID   HS10_PE1011                          STANDARD;      PRT;   622 AA.
AC   HS10_PE1011; P0C7U2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Putative neutral ceramidase C; EC=3.5.1 23;AltName:
DE   Full=N-acylsphingosine amidohydrolase 2C;AltName: Full=Non-lysosomal
DE   ceramidase C; (HS10.PE1011).
GN   Name=ASAH2C;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE1011.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ASA2C_HUMAN
CC   -!- FUNCTION: May hydrolyze the sphingolipid ceramide into sphingosine
CC       and free fatty acid (By similarity).
CC   -!- CATALYTIC ACTIVITY: N-acylsphingosine + H(2)O = a carboxylate +
CC       sphingosine.
CC   -!- SIMILARITY: Belongs to the neutral ceramidase family.
CC   -!- CAUTION: In contrast to other mammalian members of the family,
CC       ASAH2C has no predicted transmembrane domain.
CC   -!- GENE_FAMILY: HOG000209915 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000072444;ENST00000426610;ENSP00000399947.
DR   EMBL; AL954360; - ;
DR   UniProtKB/Swiss-Prot; P0C7U2; -.
DR   EMBL; AL954360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IPI; IPI00472292; -.
DR   ProteinModelPortal; P0C7U2; -.
DR   SMR; P0C7U2; 5-621.
DR   STRING; P0C7U2; -.
DR   PRIDE; P0C7U2; -.
DR   Ensembl; ENST00000426610; ENSP00000399947; ENSG00000072444.
DR   GeneCards; GC10M045947; -.
DR   HGNC; HGNC:23457; ASAH2C.
DR   neXtProt; NX_P0C7U2; -.
DR   PharmGKB; PA134984054; -.
DR   eggNOG; prNOG04205; -.
DR   GeneTree; ENSGT00390000015792; -.
DR   InParanoid; P0C7U2; -.
DR   OMA; RIPESAS; -.
DR   CleanEx; HS_ASAH2C; -.
DR   Genevestigator; P0C7U2; -.
DR   GO; GO:0017040; F:ceramidase activity; IEA:EC.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006823; Ceramidase_alk.
DR   PANTHER; PTHR12670; Ceramidase_alk; 1.
DR   HOGENOMDNA; HS10.PE1011; -.
KW   ENSG000000724441755old_1320000031; ENSP000003999477901old_1320000031;
KW   AL954360;
KW   Complete proteome; Hydrolase; Lipid metabolism; Reference proteome;
KW   Sphingolipid metabolism.
SQ   SEQUENCE   622 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDSEKSSEWR SDVLNRLQSK YGSLYRRDNV ILSGTHTHSG PAGYFQYTVF VIASEGFSNQ
     TFQHMVTGIL KSIDIAHTNM KPGKIFINKG NVDGVQINRS PYSYLQNPQS ERARYSSNTD
     KEMIVLKMVD LNGDDLGLIS WFAIHPVSMN NSNHLVNSDN VGYASYLLEQ EKNKGYLPGQ
     GPFVAAFSSS NLGDVSPNIL GPRCINTGES CDNANSTCPI GGPSMCIAKG PGQDMFDSTQ
     IIGRAMYQRA KELYASASQE VTGPLASAHQ WVDMTDVTVW LNSTHASKTC KPALGYSFAA
     GTIDGVGGLN FTQGKTEGDP FWDTIRDQIL GKPSEEIKEC HKPKPILLHT GELSKPHPWH
     PDIVDVQIIT LGSLAITAIP GEFTTMSGRR LREAVQAEFA SHGMQNMTVV ISGLCNVYTH
     YITTYEEYQA QRYEAASTIY GPHTLSAYIQ LFRNLAKAIA TDTVANLSRG PEPPFFKQLI
     VPLIPSIVDR APKGRTFGDV LQPAKPEYRV GEVAEVIFVG ANPKNSVQNQ NHQTFLTVEK
     YEATSTSWQI VCNDASWETR FYWHKGLLGL SNATVEWHIP DTAQPGIYRI RYFGHNRKQD
     ILKPAVILSF EGTSPAFEVV TI
//

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