(data stored in ACNUC27125 zone)

HOGENOM: HS10_PE1602

ID   HS10_PE1602                          STANDARD;      PRT;   524 AA.
AC   HS10_PE1602; P16298; P16299; Q5F2F9; Q8N3W4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit
DE   beta isoform; EC=3.1.3 16;AltName: Full=CAM-PRP catalytic
DE   subunit;AltName: Full=Calmodulin-dependent calcineurin A subunit beta
DE   isoform; (HS10.PE1602).
GN   Name=PPP3CB; Synonyms=CALNA2, CALNB, CNA2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE1602.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PP2BB_HUMAN
CC   -!- FUNCTION: Calcium-dependent, calmodulin-stimulated protein
CC       phosphatase. This subunit may have a role in the calmodulin
CC       activation of calcineurin.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Composed of two components (A and B), the A component is
CC       the catalytic subunit and the B component confers calcium
CC       sensitivity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist. Calcineurin A beta
CC         isoform consists of at least two isoenzymes that may result from
CC         alternative splicing events;
CC       Name=1;
CC         IsoId=P16298-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P16298-2; Sequence=VSP_005096, VSP_005097;
CC       Name=3;
CC         IsoId=P16298-3; Sequence=VSP_012617;
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-2B
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000172699 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000107758;ENST00000360663;ENSP00000353881.
DR   EMBL; AJ488506; - ;
DR   EMBL; AK300701; - ;
DR   EMBL; AL353731; - ;
DR   EMBL; AL359074; - ;
DR   EMBL; CH471083; - ;
DR   EMBL; M29550; - ;
DR   EMBL; M29551; - ;
DR   EMBL; S40012; - ;
DR   UniProtKB/Swiss-Prot; P16298; P16299; Q5F2F9; Q8N3W4; -.
DR   EMBL; M29551; AAA35706.1; -; mRNA.
DR   EMBL; M29550; AAA35705.1; -; mRNA.
DR   EMBL; AJ488506; CAD32694.1; -; mRNA.
DR   EMBL; AL353731; CAI52487.1; -; Genomic_DNA.
DR   EMBL; AL359074; CAI52487.1; JOINED; Genomic_DNA.
DR   EMBL; AL359074; CAI52473.1; -; Genomic_DNA.
DR   EMBL; AL353731; CAI52473.1; JOINED; Genomic_DNA.
DR   EMBL; CH471083; EAW54498.1; -; Genomic_DNA.
DR   IPI; IPI00181738; -.
DR   IPI; IPI00218862; -.
DR   IPI; IPI00872930; -.
DR   PIR; A36222; A36222.
DR   PIR; B36222; B36222.
DR   RefSeq; NP_001135826.1; NM_001142354.1.
DR   RefSeq; NP_066955.1; NM_021132.2.
DR   UniGene; Hs.500067; -.
DR   ProteinModelPortal; P16298; -.
DR   SMR; P16298; 24-379.
DR   IntAct; P16298; 2.
DR   STRING; P16298; -.
DR   PhosphoSite; P16298; -.
DR   PRIDE; P16298; -.
DR   Ensembl; ENST00000360663; ENSP00000353881; ENSG00000107758.
DR   GeneID; 5532; -.
DR   KEGG; hsa:5532; -.
DR   UCSC; uc001jue.1; human.
DR   UCSC; uc001jug.1; human.
DR   UCSC; uc001jui.1; human.
DR   CTD; 5532; -.
DR   GeneCards; GC10M069190; -.
DR   H-InvDB; HIX0022172; -.
DR   HGNC; HGNC:9315; PPP3CB.
DR   HPA; HPA008233; -.
DR   MIM; 114106; gene.
DR   neXtProt; NX_P16298; -.
DR   PharmGKB; PA33679; -.
DR   eggNOG; prNOG12777; -.
DR   OMA; TPHSFAN; -.
DR   OrthoDB; EOG4PVNZK; -.
DR   PhylomeDB; P16298; -.
DR   Pathway_Interaction_DB; bcr_5pathway; BCR signaling pathway.
DR   Pathway_Interaction_DB; tcrcalciumpathway; Calcium signaling in the CD4+ TCR pathway.
DR   Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; il12_stat4pathway; IL12 signaling mediated by STAT4.
DR   Pathway_Interaction_DB; il12_2pathway; IL12-mediated signaling events.
DR   Pathway_Interaction_DB; nfat_3pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes.
DR   Reactome; REACT_15295; Opioid Signalling.
DR   NextBio; 21430; -.
DR   ArrayExpress; P16298; -.
DR   Bgee; P16298; -.
DR   CleanEx; HS_PPP3CB; -.
DR   Genevestigator; P16298; -.
DR   GermOnline; ENSG00000107758; Homo sapiens.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR   HOGENOMDNA; HS10.PE1602; -.
KW   ENSG000001077581755old_1320000031; ENSP000003538817901old_1320000031;
KW   B7Z6P2_HUMAN; Q9UMB2_HUMAN; AJ488506; AK300701; AL353731; AL359074;
KW   M29550; M29551; S40012;
KW   Acetylation; Alternative splicing; Calmodulin-binding;
KW   Complete proteome; Hydrolase; Iron; Metal-binding;
KW   Protein phosphatase; Reference proteome; Zinc.
SQ   SEQUENCE   524 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAPEPARAA PPPPPPPPPP PGADRVVKAV PFPPTHRLTS EEVFDLDGIP RVDVLKNHLV
     KEGRVDEEIA LRIINEGAAI LRREKTMIEV EAPITVCGDI HGQFFDLMKL FEVGGSPANT
     RYLFLGDYVD RGYFSIECVL YLWVLKILYP STLFLLRGNH ECRHLTEYFT FKQECKIKYS
     ERVYEACMEA FDSLPLAALL NQQFLCVHGG LSPEIHTLDD IRRLDRFKEP PAFGPMCDLL
     WSDPSEDFGN EKSQEHFSHN TVRGCSYFYN YPAVCEFLQN NNLLSIIRAH EAQDAGYRMY
     RKSQTTGFPS LITIFSAPNY LDVYNNKAAV LKYENNVMNI RQFNCSPHPY WLPNFMDVFT
     WSLPFVGEKV TEMLVNVLSI CSDDELMTEG EDQFDGSAAA RKEIIRNKIR AIGKMARVFS
     VLREESESVL TLKGLTPTGM LPSGVLAGGR QTLQSATVEA IEAEKAIRGF SPPHRICSFE
     EAKGLDRINE RMPPRKDAVQ QDGFNSLNTA HATENHGTGN HTAQ
//

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