(data stored in ACNUC27125 zone)

HOGENOM: HS10_PE1616

ID   HS10_PE1616                          STANDARD;      PRT;   1684 AA.
AC   HS10_PE1616;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Inactive ubiquitin carboxyl-terminal hydrolase 54;AltName:
DE   Full=Inactive ubiquitin-specific peptidase 54; (HS10.PE1616).
GN   Name=USP54; Synonyms=C10orf29;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE1616.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:UBP54_HUMAN
CC   -!- FUNCTION: Has no peptidase activity.
CC   -!- INTERACTION:
CC       P54253:ATXN1; NbExp=3; IntAct=EBI-946185, EBI-930964;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=1;
CC         IsoId=Q70EL1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q70EL1-4; Sequence=VSP_026525, VSP_026526;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q70EL1-6; Sequence=VSP_035675, VSP_035676;
CC         Note=No experimental confirmation available;
CC       Name=4;
CC         IsoId=Q70EL1-7; Sequence=VSP_029922;
CC         Note=No experimental confirmation available;
CC       Name=5;
CC         IsoId=Q70EL1-8; Sequence=VSP_035674;
CC       Name=6;
CC         IsoId=Q70EL1-9; Sequence=VSP_035674, VSP_035678;
CC       Name=7;
CC         IsoId=Q70EL1-10; Sequence=VSP_035674, VSP_035677;
CC   -!- TISSUE SPECIFICITY: Weakly expressed in a few tissues.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC   -!- CAUTION: Although the active site residues are conserved, it lacks
CC       the conserved His residue which is normally found 9 residues
CC       before the catalytic His.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04393.1; Type=Erroneous initiation;
CC       Sequence=BAG53943.1; Type=Erroneous initiation;
CC       Sequence=BX649087; Type=Frameshift; Positions=508;
CC       Sequence=CAO03507.1; Type=Erroneous gene model prediction;
CC       Sequence=CAO03508.1; Type=Erroneous gene model prediction;
CC       Sequence=CAO03509.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000154761 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000166348;ENST00000408019;ENSP00000386080.
DR   EMBL; AC073389; - ;
DR   EMBL; AJ583820; - ;
DR   EMBL; AK094637; - ;
DR   EMBL; AK123711; - ;
DR   EMBL; AK126497; - ;
DR   EMBL; AK127213; - ;
DR   EMBL; AK127267; - ;
DR   EMBL; AK302598; - ;
DR   EMBL; AL359074; - ;
DR   EMBL; BC064967; - ;
DR   EMBL; BC130633; - ;
DR   EMBL; BX649087; - ;
DR   UniProtKB/Swiss-Prot; Q70EL1; A1L4Q4; A3KFK3; A3KFK5; A3KFK6; A3KFK7; A6PVS4; A6PVS5; -.
DR   UniProtKB/Swiss-Prot; A6PVS6; A6PVS7; B3KVY1; B9ZVM1; Q5F2F4; Q6P1N6; Q6ZSP1; Q6ZSR1; -.
DR   UniProtKB/Swiss-Prot; Q6ZTM0; Q8N1X2; -.
DR   EMBL; AJ583820; CAE47747.1; -; mRNA.
DR   EMBL; AK094637; BAC04393.1; ALT_INIT; mRNA.
DR   EMBL; AK123711; BAG53943.1; ALT_INIT; mRNA.
DR   EMBL; AK126497; BAC86566.1; -; mRNA.
DR   EMBL; AK127213; BAC86886.1; -; mRNA.
DR   EMBL; AK127267; BAC86907.1; -; mRNA.
DR   EMBL; BX649087; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC073389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359074; CAO03506.1; -; Genomic_DNA.
DR   EMBL; AL359074; CAO03507.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL359074; CAO03508.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL359074; CAO03509.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC064967; AAH64967.1; -; mRNA.
DR   EMBL; BC130633; AAI30634.1; -; mRNA.
DR   IPI; IPI00642778; -.
DR   IPI; IPI00852605; -.
DR   IPI; IPI00852839; -.
DR   IPI; IPI00877069; -.
DR   IPI; IPI00903012; -.
DR   IPI; IPI00914881; -.
DR   IPI; IPI00942140; -.
DR   RefSeq; NP_689799.3; NM_152586.3.
DR   UniGene; Hs.657355; -.
DR   ProteinModelPortal; Q70EL1; -.
DR   IntAct; Q70EL1; 7.
DR   MINT; MINT-6946944; -.
DR   STRING; Q70EL1; -.
DR   MEROPS; C19.080; -.
DR   PRIDE; Q70EL1; -.
DR   Ensembl; ENST00000339859; ENSP00000345216; ENSG00000166348.
DR   Ensembl; ENST00000408019; ENSP00000386080; ENSG00000166348.
DR   GeneID; 159195; -.
DR   KEGG; hsa:159195; -.
DR   UCSC; uc001juo.1; human.
DR   CTD; 159195; -.
DR   GeneCards; GC10M069250; -.
DR   H-InvDB; HIX0008927; -.
DR   HGNC; HGNC:23513; USP54.
DR   neXtProt; NX_Q70EL1; -.
DR   PharmGKB; PA134959960; -.
DR   GeneTree; ENSGT00440000033513; -.
DR   InParanoid; Q70EL1; -.
DR   OMA; QASGYHS; -.
DR   ArrayExpress; Q70EL1; -.
DR   Bgee; Q70EL1; -.
DR   CleanEx; HS_USP54; -.
DR   Genevestigator; Q70EL1; -.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR001394; Peptidase_C19.
DR   Pfam; PF00443; UCH; 1.
DR   PROSITE; PS00972; UCH_2_1; FALSE_NEG.
DR   PROSITE; PS00973; UCH_2_2; FALSE_NEG.
DR   PROSITE; PS50235; UCH_2_3; 1.
DR   HOGENOMDNA; HS10.PE1616; -.
KW   ENSG000001663481755old_1320000031; ENSP000003860807901old_1320000031;
KW   B7Z7X1_HUMAN; AC073389; AJ583820; AK094637; AK123711; AK126497; AK127213;
KW   AK302598; AL359074; BC064967; BC130633; BX649087;
KW   Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein;
KW   Polymorphism; Reference proteome.
SQ   SEQUENCE   1684 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS
     FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD
     AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ
     MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM
     NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG
     KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ
     DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY PYKHSHHESV VSHFSSDSQG
     TVIYNVENDS MSQSSRDTGH LTDSECNQKH TSKKGSLIER KRSSGRVRRK GDEPQASGYH
     SEGETLKEKQ APRNASKPSS STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP
     DKKPPRTLPL HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT
     QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES
     GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS WRHIPKSHSS SILEVDSTAS
     MGGWTKSQPF SGEEISSKSE LDELQEEVAR RAQEQELRRK REKELEAAKG FNPHPSRFMD
     LDELQNQGRS DGFERSLQEA ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS
     THSRALVDKK LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ
     VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR SALKLLTSVE
     VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ GSRCDNSSCS KLPPQEGRGI
     AQEQLFQEKK DPANPSPVMP GIATSERGDE HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS
     SFVLHCPDPV QKTNQCLQGQ SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ
     GVSMRDSTGF KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE
     ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS STDLGTSLPL
     DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN HILLHPHWNQ DTEQETSELE
     SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT GSADGMGRRL HSAHDPGLSK TSTAEMEHGL
     HEARTVRTSQ ATPCRGLSRE CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS
     NVRKPLETGH RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT
     SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ HIGTRFLTTP
     GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV HPVYPPSSSL HVPLRSAWNS
     DPVPGSRTPG PRRVDMPPDD DWRQSSYASH SGHRRTVGEG FLFVLSDAPR REQIRARVLQ
     HSQW
//

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