(data stored in ACNUC9543 zone)

HOGENOM: HS10_PE2930

ID   HS10_PE2930                          STANDARD;      PRT;   743 AA.
AC   HS10_PE2930;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA
DE   helicase DHX32; EC=3.6.4 13;AltName: Full=DEAD/H box 32;AltName:
DE   Full=DEAD/H helicase-like protein 1; Short=DHLP1;AltName: Full=DEAH box
DE   protein 32;AltName: Full=HuDDX32; (HS10.PE2930).
GN   Name=DHX32; Synonyms=DDX32;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS10.PE2930.
CC       Homo sapiens chromosome 10 GRCh37  sequence 1..135524747 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX32_HUMAN
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Mitochondrion.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7L7V1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7L7V1-2; Sequence=VSP_026427;
CC   -!- TISSUE SPECIFICITY: Expressed in lymphoid tissues (at protein
CC       level). Expressed in brain, heart, skeletal muscle, colon, thymus,
CC       spleen, kidney, liver, small intestine, placenta, lung, lymphoid
CC       tissues and blood leukocytes.
CC   -!- INDUCTION: Up-regulated by ionomycin in T lymphocytes. Down-
CC       regulated in acute lymphoblastic leukemia.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH37925.1; Type=Frameshift; Positions=439;
CC       Sequence=BAB15029.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000089876;ENST00000284690;ENSP00000284690.
DR   EMBL; AF427340; - ;
DR   EMBL; AF427341; - ;
DR   EMBL; AK001556; - ;
DR   EMBL; AK001751; - ;
DR   EMBL; AK024869; - ;
DR   EMBL; AK315430; - ;
DR   EMBL; AL162051; - ;
DR   EMBL; AL360176; - ;
DR   EMBL; AY064247; - ;
DR   EMBL; AY064250; - ;
DR   EMBL; BC002473; - ;
DR   EMBL; BC037925; - ;
DR   EMBL; BC068471; - ;
DR   EMBL; CH471066; - ;
DR   UniProtKB/Swiss-Prot; Q7L7V1; A8MSV2; D3DRF9; Q49AG5; Q5T3L0; Q5T3L5; Q96NY1; Q9BUN0; -.
DR   UniProtKB/Swiss-Prot; Q9H769; Q9NSL5; Q9NV74; Q9NVJ7; -.
DR   EMBL; AF427340; AAL26550.1; -; mRNA.
DR   EMBL; AF427341; AAL26551.1; -; mRNA.
DR   EMBL; AY064247; AAL55437.1; -; Genomic_DNA.
DR   EMBL; AY064250; AAL55441.1; -; mRNA.
DR   EMBL; AK001556; BAA91754.1; -; mRNA.
DR   EMBL; AK001751; BAA91882.1; -; mRNA.
DR   EMBL; AK024869; BAB15029.1; ALT_INIT; mRNA.
DR   EMBL; AL360176; CAI12094.1; -; Genomic_DNA.
DR   EMBL; AL360176; CAI12095.1; -; Genomic_DNA.
DR   EMBL; AL360176; CAI12096.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49216.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49217.1; -; Genomic_DNA.
DR   EMBL; BC002473; AAH02473.3; -; mRNA.
DR   EMBL; BC037925; AAH37925.1; ALT_FRAME; mRNA.
DR   EMBL; BC068471; AAH68471.1; -; mRNA.
DR   EMBL; AL162051; CAB82394.1; -; mRNA.
DR   IPI; IPI00334601; -.
DR   IPI; IPI00644447; -.
DR   PIR; T47184; T47184.
DR   RefSeq; NP_060650.2; NM_018180.2.
DR   UniGene; Hs.370292; -.
DR   ProteinModelPortal; Q7L7V1; -.
DR   SMR; Q7L7V1; 44-237, 451-700.
DR   IntAct; Q7L7V1; 1.
DR   STRING; Q7L7V1; -.
DR   PhosphoSite; Q7L7V1; -.
DR   PRIDE; Q7L7V1; -.
DR   Ensembl; ENST00000284690; ENSP00000284690; ENSG00000089876.
DR   GeneID; 55760; -.
DR   KEGG; hsa:55760; -.
DR   UCSC; uc001ljf.1; human.
DR   CTD; 55760; -.
DR   GeneCards; GC10M121214; -.
DR   HGNC; HGNC:16717; DHX32.
DR   MIM; 607960; gene.
DR   neXtProt; NX_Q7L7V1; -.
DR   PharmGKB; PA27219; -.
DR   eggNOG; prNOG13675; -.
DR   GeneTree; ENSGT00550000074627; -.
DR   InParanoid; Q7L7V1; -.
DR   OMA; PVEVVYL; -.
DR   OrthoDB; EOG4N30NF; -.
DR   PhylomeDB; Q7L7V1; -.
DR   NextBio; 60779; -.
DR   ArrayExpress; Q7L7V1; -.
DR   Bgee; Q7L7V1; -.
DR   Genevestigator; Q7L7V1; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00847; HA2; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; FALSE_NEG.
DR   HOGENOMDNA; HS10.PE2930; -.
KW   ENSG000000898761755old_1320000031; ENSP000002846907901old_1320000031;
KW   B2RD71_HUMAN; D3DRF9_HUMAN; AF427340; AF427341; AK001556; AK001751;
KW   AK315430; AL162051; AL360176; AY064247; AY064250; BC002473; BC037925;
KW   CH471066;
KW   Alternative splicing; ATP-binding; Complete proteome; Helicase;
KW   Hydrolase; Mitochondrion; Nucleotide-binding; Nucleus; Polymorphism;
KW   Reference proteome.
SQ   SEQUENCE   743 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEEEGLECPN SSSEKRYFPE SLDSSDGDEE EVLACEDLEL NPFDGLPYSS RYYKLLKERE
     DLPIWKEKYS FMENLLQNQI VIVSGDAKCG KSAQVPQWCA EYCLSIHYQH GGVICTQVHK
     QTVVQLALRV ADEMDVNIGH EVGYVIPFEN CCTNETILRY CTDDMLQREM MSNPFLGSYG
     VIILDDIHER SIATDVLLGL LKDVLLARPE LKLIINSSPH LISKLNSYYG NVPVIEVKNK
     HPVEVVYLSE AQKDSFESIL RLIFEIHHSG EKGDIVVFLA CEQDIEKVCE TVYQGSNLNP
     DLGELVVVPL YPKEKCSLFK PLDETEKRCQ VYQRRVVLTT SSGEFLIWSN SVRFVIDVGV
     ERRKVYNPRI RANSLVMQPI SQSQAEIRKQ ILGSSSSGKF FCLYTEEFAS KDMTPLKPAE
     MQEANLTSMV LFMKRIDIAG LGHCDFMNRP APESLMQALE DLDYLAALDN DGNLSEFGII
     MSEFPLDPQL SKSILASCEF DCVDEVLTIA AMVTAPNCFS HVPHGAEEAA LTCWKTFLHP
     EGDHFTLISI YKAYQDTTLN SSSEYCVEKW CRDYFLNCSA LRMADVIRAE LLEIIKRIEL
     PYAEPAFGSK ENTLNIKKAL LSGYFMQIAR DVDGSGNYLM LTHKQVAQLH PLSGYSITKK
     MPEWVLFHKF SISENNYIRI TSEISPELFM QLVPQYYFSN LPPSESKDIL QQVVDHLSPV
     STMNKEQQMC ETCPETEQRC TLQ
//

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