(data stored in ACNUC29543 zone)

HOGENOM: HS11_PE1068

ID   HS11_PE1068                          STANDARD;      PRT;   286 AA.
AC   HS11_PE1068; Q96Q83; A6NDJ1; Q3SYI0; Q6NX57; Q96BU8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog
DE   3;AltName: Full=DEPC-1;AltName: Full=Prostate cancer antigen 1;
DE   (HS11.PE1068).
GN   Name=ALKBH3; Synonyms=ABH3, DEPC1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE1068.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB3_HUMAN
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA containing 1-
CC       methyladenine and 3-methylcytosine by oxidative demethylation. Has
CC       a strong preference for single-stranded DNA. May also act on RNA.
CC       Requires molecular oxygen, alpha-ketoglutarate and iron.
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit.
CC   -!- ENZYME REGULATION: Activated by ascorbate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96Q83-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96Q83-2; Sequence=VSP_019125, VSP_019126, VSP_019127;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Detected in heart, pancreas,
CC       skeletal muscle, thymus, testis, ovary, spleen, prostate, small
CC       intestine, peripheral blood leukocytes, urinary bladder and colon.
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH15155.1; Type=Erroneous initiation;
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/depc1/";
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000166199;ENST00000302708;ENSP00000302232.
DR   EMBL; AB042029; - ;
DR   EMBL; AC087521; - ;
DR   EMBL; BC015155; - ;
DR   EMBL; BC067257; - ;
DR   EMBL; BC103812; - ;
DR   EMBL; BC103813; - ;
DR   EMBL; BC103814; - ;
DR   EMBL; CH471064; - ;
DR   EMBL; DQ196343; - ;
DR   UniProtKB/Swiss-Prot; Q96Q83; A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; -.
DR   EMBL; AB042029; BAB70508.1; -; mRNA.
DR   EMBL; DQ196343; ABA27096.1; -; Genomic_DNA.
DR   EMBL; AC087521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68078.1; -; Genomic_DNA.
DR   EMBL; BC015155; AAH15155.1; ALT_INIT; mRNA.
DR   EMBL; BC103812; AAI03813.1; -; mRNA.
DR   EMBL; BC103813; AAI03814.1; -; mRNA.
DR   EMBL; BC103814; AAI03815.1; -; mRNA.
DR   EMBL; BC067257; AAH67257.1; -; mRNA.
DR   IPI; IPI00076597; -.
DR   IPI; IPI00433171; -.
DR   RefSeq; NP_631917.1; NM_139178.3.
DR   UniGene; Hs.720708; -.
DR   PDB; 2IUW; X-ray; 1.50 A; A=70-286.
DR   PDBsum; 2IUW; -.
DR   ProteinModelPortal; Q96Q83; -.
DR   SMR; Q96Q83; 70-279.
DR   STRING; Q96Q83; -.
DR   PhosphoSite; Q96Q83; -.
DR   PRIDE; Q96Q83; -.
DR   Ensembl; ENST00000302708; ENSP00000302232; ENSG00000166199.
DR   GeneID; 221120; -.
DR   KEGG; hsa:221120; -.
DR   UCSC; uc001mxs.1; human.
DR   CTD; 221120; -.
DR   GeneCards; GC11P043611; -.
DR   H-InvDB; HIX0018784; -.
DR   HGNC; HGNC:30141; ALKBH3.
DR   HPA; CAB005007; -.
DR   HPA; HPA009674; -.
DR   MIM; 610603; gene.
DR   neXtProt; NX_Q96Q83; -.
DR   PharmGKB; PA143485293; -.
DR   eggNOG; prNOG17687; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q96Q83; -.
DR   OMA; HWHPVLS; -.
DR   OrthoDB; EOG41JZCZ; -.
DR   PhylomeDB; Q96Q83; -.
DR   Reactome; REACT_216; DNA Repair.
DR   DrugBank; DB00126; Vitamin C.
DR   NextBio; 91204; -.
DR   ArrayExpress; Q96Q83; -.
DR   Bgee; Q96Q83; -.
DR   CleanEx; HS_ALKBH3; -.
DR   Genevestigator; Q96Q83; -.
DR   GermOnline; ENSG00000166199; Homo sapiens.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0003684; F:damaged DNA binding; EXP:Reactome.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; IDA:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IDA:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IDA:UniProtKB.
DR   GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IDA:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; HS11.PE1068; -.
KW   ENSG000001661991755old_1320000031; ENSP000003022327901old_1320000031;
KW   AB042029; AC087521; BC015155; BC067257; BC103812; BC103813; BC103814;
KW   DQ196343;
KW   3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
KW   Dioxygenase; DNA damage; DNA repair; Iron; Metal-binding; Nucleus;
KW   Oxidoreductase; Polymorphism; Reference proteome; Vitamin C.
SQ   SEQUENCE   286 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEEKRRRARV QGAWAAPVKS QAIAQPATTA KSHLHQKPGQ TWKNKEHHLS DREFVFKEPQ
     QVVRRAPEPR VIDREGVYEI SLSPTGVSRV CLYPGFVDVK EADWILEQLC QDVPWKQRTG
     IREDITYQQP RLTAWYGELP YTYSRITMEP NPHWHPVLRT LKNRIEENTG HTFNSLLCNL
     YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRTFEMRKK PPPEENGDYT YVERVKIPLD
     HGTLLIMEGA TQADWQHRVP KEYHSREPRV NLTFRTVYPD PRGAPW
//

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