(data stored in ACNUC1829 zone)

HOGENOM: HS11_PE1081

ID   HS11_PE1081                          STANDARD;      PRT;   267 AA.
AC   HS11_PE1081; P27701; D3DQN6; Q7Z2D4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD82 antigen;AltName: Full=C33 antigen;AltName:
DE   Full=IA4;AltName: Full=Inducible membrane protein R2;AltName:
DE   Full=Metastasis suppressor Kangai-1;AltName: Full=Suppressor of
DE   tumorigenicity 6 protein;AltName: Full=Tetraspanin-27;
DE   Short=Tspan-27;AltName: CD_antigen=CD82; (HS11.PE1081).
GN   Name=CD82; Synonyms=KAI1, SAR2, ST6, TSPAN27;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE1081.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD82_HUMAN
CC   -!- FUNCTION: Associates with CD4 or CD8 and delivers costimulatory
CC       signals for the TCR/CD3 pathway.
CC   -!- SUBUNIT: Interacts directly with IGSF8.
CC   -!- INTERACTION:
CC       Q8TAA9:VANGL1; NbExp=6; IntAct=EBI-682379, EBI-682393;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Lymphoid specific.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000085117;ENST00000227155;ENSP00000227155.
DR   EMBL; BC000726; - ;
DR   EMBL; BC001821; - ;
DR   EMBL; CH471064; - ;
DR   EMBL; CR407650; - ;
DR   EMBL; CR542255; - ;
DR   EMBL; S48196; - ;
DR   EMBL; U20770; - ;
DR   EMBL; U67268; - ;
DR   EMBL; U67269; - ;
DR   EMBL; U67270; - ;
DR   EMBL; U67271; - ;
DR   EMBL; U67272; - ;
DR   EMBL; U67273; - ;
DR   EMBL; U67274; - ;
DR   EMBL; X53795; - ;
DR   UniProtKB/Swiss-Prot; P27701; D3DQN6; Q7Z2D4; -.
DR   EMBL; X53795; CAA37804.1; -; mRNA.
DR   EMBL; S48196; AAB23825.1; -; mRNA.
DR   EMBL; U20770; AAC50133.1; -; mRNA.
DR   EMBL; U67274; AAC51205.1; -; Genomic_DNA.
DR   EMBL; U67268; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; U67269; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; U67270; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; U67271; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; U67272; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; U67273; AAC51205.1; JOINED; Genomic_DNA.
DR   EMBL; CR542255; CAG47051.1; -; mRNA.
DR   EMBL; CH471064; EAW68063.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68064.1; -; Genomic_DNA.
DR   EMBL; BC000726; AAH00726.1; -; mRNA.
DR   EMBL; BC001821; AAH01821.1; -; mRNA.
DR   IPI; IPI00020446; -.
DR   PIR; I38942; A46493.
DR   RefSeq; NP_001020015.1; NM_001024844.1.
DR   RefSeq; NP_002222.1; NM_002231.3.
DR   UniGene; Hs.527778; -.
DR   ProteinModelPortal; P27701; -.
DR   IntAct; P27701; 1.
DR   STRING; P27701; -.
DR   PhosphoSite; P27701; -.
DR   PRIDE; P27701; -.
DR   Ensembl; ENST00000227155; ENSP00000227155; ENSG00000085117.
DR   Ensembl; ENST00000441195; ENSP00000388758; ENSG00000085117.
DR   GeneID; 3732; -.
DR   KEGG; hsa:3732; -.
DR   UCSC; uc001myc.1; human.
DR   CTD; 3732; -.
DR   GeneCards; GC11P044296; -.
DR   H-InvDB; HIX0017389; -.
DR   HGNC; HGNC:6210; CD82.
DR   HPA; CAB002508; -.
DR   HPA; HPA028900; -.
DR   MIM; 600623; gene.
DR   neXtProt; NX_P27701; -.
DR   PharmGKB; PA142672155; -.
DR   eggNOG; prNOG18880; -.
DR   InParanoid; P27701; -.
DR   OMA; KCCGWVS; -.
DR   PhylomeDB; P27701; -.
DR   NextBio; 14607; -.
DR   ArrayExpress; P27701; -.
DR   Bgee; P27701; -.
DR   CleanEx; HS_CD82; -.
DR   Genevestigator; P27701; -.
DR   GermOnline; ENSG00000085117; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS11.PE1081; -.
KW   ENSG000000851171755old_1320000031; ENSP000002271557901old_1320000031;
KW   D3DQN6_HUMAN; Q6LET0_HUMAN; BC000726; BC001821; CH471064; CR407650;
KW   S48196; U20770; U67268; U67269; U67270; U67271; U67272; U67273; U67274;
KW   X53795;
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   267 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS SLRMGAYVFI
     GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV TAGALFYFNM GKLKQEMGGI
     VTELIRDYNS SREDSLQDAW DYVQAQVKCC GWVSFYNWTD NAELMNRPEV TYPCSCEVKG
     EEDNSLSVRK GFCEAPGNRT QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI
     IELLGMVLSI CLCRHVHSED YSKVPKY
//

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