(data stored in ACNUC31108 zone)

HOGENOM: HS11_PE117

ID   HS11_PE117                           STANDARD;      PRT;   253 AA.
AC   HS11_PE117; P48509; A8KAK8; Q14826; Q86U54; Q96TE3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD151 antigen;AltName: Full=GP27;AltName: Full=Membrane
DE   glycoprotein SFA-1;AltName: Full=Platelet-endothelial tetraspan antigen
DE   3; Short=PETA-3;AltName: Full=Tetraspanin-24; Short=Tspan-24;AltName:
DE   CD_antigen=CD151; (HS11.PE117).
GN   Name=CD151; Synonyms=TSPAN24;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE117.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD151_HUMAN
CC   -!- FUNCTION: Essential for the proper assembly of the glomerular and
CC       tubular basement membranes in kidney.
CC   -!- SUBUNIT: Interacts with integrins alpha3beta1, alpha5beta1,
CC       alpha3beta1 and alpha6beta4, with CD9 and CD181.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tissues including
CC       vascular endothelium and epidermis. Expressed on erythroid cells,
CC       with a higher level of expression in erythroid precursors than on
CC       mature erythrocytes.
CC   -!- INDUCTION: By HTLV-1.
CC   -!- POLYMORPHISM: CD151 defines the MER2=RAPH1 antigen of the RAPH
CC       blood group system. 92% of Caucasians are MER2-positive and 8% are
CC       apparently MER2-negative.
CC   -!- DISEASE: Defects in CD151 are the cause of nephropathy with
CC       pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057].
CC       NPEBD is characterized by the association of hereditary nephritis,
CC       epidermolysis bullosa, deafness, and beta-thalassemia minor.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene
CC       mutation database;
CC       URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=raph";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/cd151/";
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000177697;ENST00000397421;ENSP00000380566.
DR   EMBL; AF315942; - ;
DR   EMBL; AK223186; - ;
DR   EMBL; AK293073; - ;
DR   EMBL; BC001374; - ;
DR   EMBL; BC013302; - ;
DR   EMBL; BT007397; - ;
DR   EMBL; BT020132; - ;
DR   EMBL; CH471158; - ;
DR   EMBL; CR456826; - ;
DR   EMBL; CR542098; - ;
DR   EMBL; D29963; - ;
DR   EMBL; DQ074789; - ;
DR   EMBL; U14650; - ;
DR   UniProtKB/Swiss-Prot; P48509; A8KAK8; Q14826; Q86U54; Q96TE3; -.
DR   EMBL; U14650; AAA87064.1; -; mRNA.
DR   EMBL; D29963; BAA06229.1; -; mRNA.
DR   EMBL; AF315942; AAK14179.1; -; Genomic_DNA.
DR   EMBL; BT007397; AAP36061.1; -; mRNA.
DR   EMBL; BT020132; AAV38934.1; -; mRNA.
DR   EMBL; CR456826; CAG33107.1; -; mRNA.
DR   EMBL; CR542098; CAG46895.1; -; mRNA.
DR   EMBL; AK293073; BAF85762.1; -; mRNA.
DR   EMBL; DQ074789; AAY68211.1; -; Genomic_DNA.
DR   EMBL; CH471158; EAX02400.1; -; Genomic_DNA.
DR   EMBL; BC001374; AAH01374.1; -; mRNA.
DR   EMBL; BC013302; AAH13302.1; -; mRNA.
DR   IPI; IPI00298851; -.
DR   RefSeq; NP_001034579.1; NM_001039490.1.
DR   RefSeq; NP_004348.2; NM_004357.4.
DR   RefSeq; NP_620598.1; NM_139029.1.
DR   RefSeq; NP_620599.1; NM_139030.3.
DR   UniGene; Hs.654379; -.
DR   ProteinModelPortal; P48509; -.
DR   STRING; P48509; -.
DR   PhosphoSite; P48509; -.
DR   PeptideAtlas; P48509; -.
DR   PRIDE; P48509; -.
DR   Ensembl; ENST00000322008; ENSP00000324101; ENSG00000177697.
DR   Ensembl; ENST00000397420; ENSP00000380565; ENSG00000177697.
DR   Ensembl; ENST00000397421; ENSP00000380566; ENSG00000177697.
DR   Ensembl; ENST00000436957; ENSP00000413175; ENSG00000177697.
DR   GeneID; 977; -.
DR   KEGG; hsa:977; -.
DR   UCSC; uc001lry.1; human.
DR   CTD; 977; -.
DR   GeneCards; GC11P000648; -.
DR   H-InvDB; HIX0021759; -.
DR   HGNC; HGNC:1630; CD151.
DR   HPA; CAB002428; -.
DR   HPA; HPA011906; -.
DR   MIM; 179620; phenotype.
DR   MIM; 602243; gene.
DR   MIM; 609057; phenotype.
DR   neXtProt; NX_P48509; -.
DR   PharmGKB; PA26189; -.
DR   eggNOG; prNOG13048; -.
DR   InParanoid; P48509; -.
DR   OMA; YLLFTFN; -.
DR   OrthoDB; EOG46144V; -.
DR   PhylomeDB; P48509; -.
DR   Reactome; REACT_20676; Cell junction organization.
DR   NextBio; 4102; -.
DR   ArrayExpress; P48509; -.
DR   Bgee; P48509; -.
DR   CleanEx; HS_CD151; -.
DR   Genevestigator; P48509; -.
DR   GermOnline; ENSG00000177697; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0005624; C:membrane fraction; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; NAS:ProtInc.
DR   GO; GO:0031581; P:hemidesmosome assembly; EXP:Reactome.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS11.PE117; -.
KW   ENSG000001776971755old_1320000031; ENSP000003805667901old_1320000031;
KW   Q53FU5_HUMAN; AF315942; AK223186; AK293073; BC001374; BC013302; BT007397;
KW   CH471158; CR456826; CR542098; D29963; DQ074789; U14650;
KW   Blood group antigen; Complete proteome; Deafness;
KW   Epidermolysis bullosa; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW   Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   253 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT
     AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT
     ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV
     PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF
     TCCLYRSLKL EHY
//

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