(data stored in ACNUC20591 zone)

HOGENOM: HS11_PE1996

ID   HS11_PE1996                          STANDARD;      PRT;   1042 AA.
AC   HS11_PE1996; Q96FS4; O14518; O60484; O60618; Q2YD83;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Signal-induced proliferation-associated protein 1;
DE   Short=Sipa-1;AltName: Full=GTPase-activating protein Spa-1;AltName:
DE   Full=p130 SPA-1; (HS11.PE1996).
GN   Name=SIPA1; Synonyms=SPA1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE1996.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SIPA1_HUMAN
CC   -!- FUNCTION: GTPase activator for the nuclear Ras-related regulatory
CC       proteins Rap1 and Rap2 in vitro, converting it to the putatively
CC       inactive GDP-bound state.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region.
CC       Endomembrane system; Peripheral membrane protein. Note=Mostly
CC       localized in the perinuclear membraneous region.
CC   -!- TISSUE SPECIFICITY: Expressed in fetal as well as in adult
CC       tissues. Expressed abundantly in the lymphoid tissues such as
CC       thymus, spleen and peripheral blood lymphocytes and also shows a
CC       significant expression in the spinal cord.
CC   -!- INDUCTION: Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA)
CC       in promyelocytic HL-60 cells.
CC   -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC   -!- SIMILARITY: Contains 1 Rap-GAP domain.
CC   -!- GENE_FAMILY: HOG000154327 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000213445;ENST00000394224;ENSP00000377771.
DR   EMBL; AB005666; - ;
DR   EMBL; AF029789; - ;
DR   EMBL; AF052233; - ;
DR   EMBL; AF052234; - ;
DR   EMBL; AF052235; - ;
DR   EMBL; AF052236; - ;
DR   EMBL; AF052237; - ;
DR   EMBL; AF052238; - ;
DR   EMBL; BC010492; - ;
DR   EMBL; BC110353; - ;
DR   UniProtKB/Swiss-Prot; Q96FS4; O14518; O60484; O60618; Q2YD83; -.
DR   EMBL; AB005666; BAA22197.1; -; mRNA.
DR   EMBL; AF052238; AAC32559.1; -; Genomic_DNA.
DR   EMBL; AF052233; AAC32559.1; JOINED; Genomic_DNA.
DR   EMBL; AF052234; AAC32559.1; JOINED; Genomic_DNA.
DR   EMBL; AF052235; AAC32559.1; JOINED; Genomic_DNA.
DR   EMBL; AF052236; AAC32559.1; JOINED; Genomic_DNA.
DR   EMBL; AF052237; AAC32559.1; JOINED; Genomic_DNA.
DR   EMBL; AF029789; AAC32547.1; -; mRNA.
DR   EMBL; BC010492; AAH10492.1; -; mRNA.
DR   EMBL; BC110353; AAI10354.1; -; mRNA.
DR   IPI; IPI00305305; -.
DR   RefSeq; NP_006738.3; NM_006747.3.
DR   RefSeq; NP_694985.29; NM_153253.29.
DR   UniGene; Hs.530477; -.
DR   ProteinModelPortal; Q96FS4; -.
DR   SMR; Q96FS4; 206-547, 680-763.
DR   STRING; Q96FS4; -.
DR   PhosphoSite; Q96FS4; -.
DR   PeptideAtlas; Q96FS4; -.
DR   PRIDE; Q96FS4; -.
DR   Ensembl; ENST00000308755; ENSP00000312246; ENSG00000213445.
DR   Ensembl; ENST00000394224; ENSP00000377771; ENSG00000213445.
DR   GeneID; 6494; -.
DR   KEGG; hsa:6494; -.
DR   UCSC; uc001ofb.1; human.
DR   CTD; 6494; -.
DR   GeneCards; GC11P061734; -.
DR   H-InvDB; HIX0009803; -.
DR   HGNC; HGNC:10885; SIPA1.
DR   HPA; CAB020833; -.
DR   MIM; 602180; gene.
DR   neXtProt; NX_Q96FS4; -.
DR   PharmGKB; PA35785; -.
DR   eggNOG; prNOG12448; -.
DR   GeneTree; ENSGT00550000074284; -.
DR   InParanoid; Q96FS4; -.
DR   OMA; PEPVQDE; -.
DR   PhylomeDB; Q96FS4; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 25241; -.
DR   ArrayExpress; Q96FS4; -.
DR   Bgee; Q96FS4; -.
DR   CleanEx; HS_SIPA1; -.
DR   Genevestigator; Q96FS4; -.
DR   GermOnline; ENSG00000173442; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046582; F:Rap GTPase activator activity; NAS:UniProtKB.
DR   GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR   GO; GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.
DR   GO; GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
DR   GO; GO:0007162; P:negative regulation of cell adhesion; NAS:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; NAS:UniProtKB.
DR   GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR   InterPro; IPR001478; PDZ/DHR/GLGF.
DR   InterPro; IPR000331; Rap_GAP.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
DR   HOGENOMDNA; HS11.PE1996; -.
KW   ENSG000002134451755old_1320000031; ENSP000003777717901old_1320000031;
KW   AB005666; AF029789; AF052233; AF052234; AF052235; AF052236; AF052237;
KW   BC010492; BC110353;
KW   Coiled coil; Complete proteome; Cytoplasm; GTPase activation;
KW   Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome.
SQ   SEQUENCE   1042 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL LRSGSDAGEA
     RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA EEPEPAFPPV LEPRWFAHYD
     VQSLLFDWAP RSQGMGSHSE ASSGTLASAE DQAASSDLLH GAPGFVCELG GEGELGLGGP
     ASPPVPPALP NAAVSILEEP QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP
     VAVSLRREEK EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA
     PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM YNNQEAGPAF
     MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ DHEIMFHVST MLPYTPNNQQ
     QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT
     QDTPAFGPAL PAGGGPFAAN ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA
     TNEVTTTSLD SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAAPG ARVAAGAQAS
     GPEGIEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY HGRGEAITLR
     FDGSPGQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF EVDAEGFVTH VERFTFAETA
     GLRPGARLLR VCGQTLPSLR PEAAAQLLRS APKVCVTVLP PDESGRPRRS FSELYTLSLQ
     EPSRRGAPDP VQDEVQGVTL LPTTKQLLHL CLQDGGSPPG PGDLAEERTE FLHSQNSLSP
     RSSLSDEAPV LPNTTPDLLL ATTAKPSVPS ADSETPLTQD RPGSPSGSED KGNPAPELRA
     SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG QPIPESGDPK
     GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA ALEEEVRSLR HNNRRLQAES
     ESAATRLLLA SKQLGSPTAD LA
//

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