(data stored in ACNUC8465 zone)

HOGENOM: HS11_PE2127

ID   HS11_PE2127                          STANDARD;      PRT;   210 AA.
AC   HS11_PE2127; O00212;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoD;AltName:
DE   Full=Rho-related protein HP1; Short=RhoHP1;Flags: Precursor;
DE   (HS11.PE2127).
GN   Name=RHOD; Synonyms=ARHD;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE2127.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOD_HUMAN
CC   -!- FUNCTION: Involved in endosome dynamics. May coordinate membrane
CC       transport with the function of the cytoskeleton. Participates in
CC       reorganization of actin cytoskeleton (By similarity).
CC   -!- SUBUNIT: In the GTP-bound form, interacts with DIAPH2 isoform 3.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- TISSUE SPECIFICITY: Heart, placenta, liver, skeletal muscle, and
CC       pancreas and, with weaker intensity, in several other tissues.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000173156;ENST00000308831;ENSP00000308576.
DR   EMBL; AF498973; - ;
DR   EMBL; AP000729; - ;
DR   EMBL; BC001338; - ;
DR   EMBL; D85815; - ;
DR   UniProtKB/Swiss-Prot; O00212; -.
DR   EMBL; D85815; BAA19652.1; -; Genomic_DNA.
DR   EMBL; AF498973; AAM21120.1; -; mRNA.
DR   EMBL; AP000729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC001338; AAH01338.1; -; mRNA.
DR   IPI; IPI00010841; -.
DR   RefSeq; NP_055393.1; NM_014578.3.
DR   UniGene; Hs.15114; -.
DR   PDB; 2J1L; X-ray; 2.50 A; A=7-197.
DR   PDBsum; 2J1L; -.
DR   ProteinModelPortal; O00212; -.
DR   SMR; O00212; 15-193.
DR   STRING; O00212; -.
DR   PhosphoSite; O00212; -.
DR   PRIDE; O00212; -.
DR   Ensembl; ENST00000308831; ENSP00000308576; ENSG00000173156.
DR   GeneID; 29984; -.
DR   KEGG; hsa:29984; -.
DR   UCSC; uc001ojv.1; human.
DR   CTD; 29984; -.
DR   GeneCards; GC11P063152; -.
DR   H-InvDB; HIX0020551; -.
DR   HGNC; HGNC:670; RHOD.
DR   HPA; HPA024394; -.
DR   MIM; 605781; gene.
DR   neXtProt; NX_O00212; -.
DR   PharmGKB; PA24952; -.
DR   eggNOG; prNOG05048; -.
DR   GeneTree; ENSGT00550000074256; -.
DR   InParanoid; O00212; -.
DR   OMA; ENVHAVF; -.
DR   OrthoDB; EOG4P5KB3; -.
DR   PhylomeDB; O00212; -.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   NextBio; 52746; -.
DR   ArrayExpress; O00212; -.
DR   Bgee; O00212; -.
DR   CleanEx; HS_RHOD; -.
DR   Genevestigator; O00212; -.
DR   GermOnline; ENSG00000173156; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   GO; GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS11.PE2127; -.
KW   ENSG000001731561755old_1320000031; ENSP000003085767901old_1320000031;
KW   AF498973; AP000729; BC001338; D85815;
KW   3D-structure; Cell membrane; Complete proteome; GTP-binding;
KW   Lipoprotein; Membrane; Methylation; Nucleotide-binding; Polymorphism;
KW   Prenylation; Reference proteome.
SQ   SEQUENCE   210 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV
     KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK
     KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH
     AVFQEAAEVA LSSRGRNFWR RITQGFCVVT
//

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