(data stored in ACNUC21562 zone)

HOGENOM: HS11_PE2224

ID   HS11_PE2224                          STANDARD;      PRT;   321 AA.
AC   HS11_PE2224; Q8TDS7; Q8NGK7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mas-related G-protein coupled receptor member D;AltName:
DE   Full=Beta-alanine receptor;AltName: Full=G-protein coupled receptor TGR7;
DE   (HS11.PE2224).
GN   Name=MRGPRD; Synonyms=MRGD;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE2224.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MRGRD_HUMAN
CC   -!- FUNCTION: May regulate nociceptor function and/or development,
CC       including the sensation or modulation of pain. Functions as a
CC       specific membrane receptor for beta-alanine. Beta-alanine at
CC       micromolar doses specifically evoked Ca(2+) influx in cells
CC       expressing the receptor. Beta-alanine decreases forskolin-
CC       stimulated cAMP production in cells expressing the receptor,
CC       suggesting that the receptor couples with G-protein G(q) and G(i).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Note=Localized at the plasma membrane but internalized into the
CC       cytoplasm after treatment with beta-alanine.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06005.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000172938;ENST00000309106;ENSP00000310631.
DR   EMBL; AB065786; - ;
DR   EMBL; AB083627; - ;
DR   EMBL; AB154410; - ;
DR   EMBL; AY427820; - ;
DR   UniProtKB/Swiss-Prot; Q8TDS7; Q8NGK7; -.
DR   EMBL; AY427820; AAR05120.1; -; mRNA.
DR   EMBL; AB154410; BAD20638.1; -; mRNA.
DR   EMBL; AB083627; BAB89340.1; -; Genomic_DNA.
DR   EMBL; AB065786; BAC06005.1; ALT_INIT; Genomic_DNA.
DR   IPI; IPI00447219; -.
DR   RefSeq; NP_944605.2; NM_198923.2.
DR   UniGene; Hs.527802; -.
DR   ProteinModelPortal; Q8TDS7; -.
DR   SMR; Q8TDS7; 110-141.
DR   STRING; Q8TDS7; -.
DR   PRIDE; Q8TDS7; -.
DR   Ensembl; ENST00000309106; ENSP00000310631; ENSG00000172938.
DR   GeneID; 116512; -.
DR   KEGG; hsa:116512; -.
DR   UCSC; uc001oon.1; human.
DR   CTD; 116512; -.
DR   GeneCards; GC11M065086; -.
DR   H-InvDB; HIX0035840; -.
DR   HGNC; HGNC:29626; MRGPRD.
DR   HPA; HPA031346; -.
DR   MIM; 607231; gene.
DR   neXtProt; NX_Q8TDS7; -.
DR   PharmGKB; PA134978563; -.
DR   eggNOG; prNOG16936; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   InParanoid; Q8TDS7; -.
DR   OMA; DKVHELM; -.
DR   OrthoDB; EOG4MW86R; -.
DR   NextBio; 79958; -.
DR   ArrayExpress; Q8TDS7; -.
DR   Bgee; Q8TDS7; -.
DR   CleanEx; HS_MRGPRD; -.
DR   Genevestigator; Q8TDS7; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; HS11.PE2224; -.
KW   ENSG000001729381755old_1320000031; ENSP000003106317901old_1320000031;
KW   AB065786; AB083627; AB154410; AY427820;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   321 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP
     FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS
     TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM
     VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY
     WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
     REEPELEGGE TPTVGTNEMG A
//

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