(data stored in ACNUC3724 zone)

HOGENOM: HS11_PE2414

ID   HS11_PE2414                          STANDARD;      PRT;   466 AA.
AC   HS11_PE2414; Q15054; B7ZAI6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA polymerase delta subunit 3;AltName: Full=DNA polymerase
DE   delta subunit p66; (HS11.PE2414).
GN   Name=POLD3; Synonyms=KIAA0039;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE2414.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DPOD3_HUMAN
CC   -!- FUNCTION: Required for optimal DNA polymerase delta activity.
CC   -!- SUBUNIT: Heterotetramer composed of subunits of 125 kDa, 50 kDa,
CC       66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA.
CC   -!- INTERACTION:
CC       P12004:PCNA; NbExp=4; IntAct=EBI-864956, EBI-358311;
CC       P49005:POLD2; NbExp=5; IntAct=EBI-864956, EBI-372354;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA05039.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000008055 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000077514;ENST00000263681;ENSP00000263681.
DR   EMBL; AK297375; - ;
DR   EMBL; AK302677; - ;
DR   EMBL; AK316301; - ;
DR   EMBL; AK316370; - ;
DR   EMBL; BC020587; - ;
DR   EMBL; BC032636; - ;
DR   EMBL; BC092454; - ;
DR   EMBL; BC108908; - ;
DR   EMBL; BC108909; - ;
DR   EMBL; CH471076; - ;
DR   EMBL; D26018; - ;
DR   UniProtKB/Swiss-Prot; Q15054; B7ZAI6; -.
DR   EMBL; D26018; BAA05039.1; ALT_INIT; mRNA.
DR   EMBL; AK316301; BAH14672.1; -; mRNA.
DR   EMBL; CH471076; EAW74942.1; -; Genomic_DNA.
DR   IPI; IPI00394926; -.
DR   RefSeq; NP_006582.1; NM_006591.1.
DR   UniGene; Hs.82502; -.
DR   PDB; 1U76; X-ray; 2.60 A; B/D/F=452-466.
DR   PDB; 3E0J; X-ray; 3.00 A; B/D/F/H=1-144.
DR   PDBsum; 1U76; -.
DR   PDBsum; 3E0J; -.
DR   ProteinModelPortal; Q15054; -.
DR   SMR; Q15054; 2-144.
DR   DIP; DIP-35772N; -.
DR   IntAct; Q15054; 4.
DR   MINT; MINT-2789689; -.
DR   STRING; Q15054; -.
DR   PhosphoSite; Q15054; -.
DR   PeptideAtlas; Q15054; -.
DR   PRIDE; Q15054; -.
DR   Ensembl; ENST00000263681; ENSP00000263681; ENSG00000077514.
DR   GeneID; 10714; -.
DR   KEGG; hsa:10714; -.
DR   UCSC; uc001ovf.1; human.
DR   CTD; 10714; -.
DR   GeneCards; GC11P070599; -.
DR   H-InvDB; HIX0009934; -.
DR   HGNC; HGNC:20932; POLD3.
DR   HPA; HPA039627; -.
DR   MIM; 611415; gene.
DR   neXtProt; NX_Q15054; -.
DR   PharmGKB; PA134868595; -.
DR   InParanoid; Q15054; -.
DR   OMA; QQPKGIM; -.
DR   OrthoDB; EOG49KFQR; -.
DR   PhylomeDB; Q15054; -.
DR   Reactome; REACT_152; Cell Cycle, Mitotic.
DR   Reactome; REACT_216; DNA Repair.
DR   Reactome; REACT_22172; Chromosome Maintenance.
DR   Reactome; REACT_383; DNA Replication.
DR   NextBio; 40675; -.
DR   ArrayExpress; Q15054; -.
DR   Bgee; Q15054; -.
DR   Genevestigator; Q15054; -.
DR   GermOnline; ENSG00000077514; Homo sapiens.
DR   GO; GO:0043625; C:delta DNA polymerase complex; NAS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006284; P:base-excision repair; TAS:Reactome.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.
DR   GO; GO:0000731; P:DNA synthesis involved in DNA repair; NAS:UniProtKB.
DR   GO; GO:0006298; P:mismatch repair; NAS:UniProtKB.
DR   GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IMP:UniProtKB.
DR   GO; GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.
DR   GO; GO:0000722; P:telomere maintenance via recombination; TAS:Reactome.
DR   GO; GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
DR   InterPro; IPR019038; DNA_polymerase_subunit_Cdc27.
DR   Pfam; PF09507; CDC27; 1.
DR   HOGENOMDNA; HS11.PE2414; -.
KW   ENSG000000775141755old_1320000031; ENSP000002636817901old_1320000031;
KW   B4DMA6_HUMAN; B4DYZ7_HUMAN; B7ZAQ5_HUMAN; Q05BV7_HUMAN; Q32MZ9_HUMAN;
KW   Q569I8_HUMAN; Q8WUF6_HUMAN; AK297375; AK302677; AK316301; AK316370;
KW   BC032636; BC092454; BC108908; BC108909; CH471076; D26018;
KW   3D-structure; Acetylation; Complete proteome;
KW   Direct protein sequencing; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus;
KW   Phosphoprotein; Polymorphism; Reference proteome; Transferase.
SQ   SEQUENCE   466 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MADQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYDYVERKRK ENSGAQLHVT
     YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD
     ILKSNLQNCS KFSAIQCAAA VPRAPAESSS SSKKFEQSHL HMSSETQANN ELTTNGHGPP
     ASKQVSQQPK GIMGMFASKA AAKTQETNKE TKTEAKEVTN ASAAGNKAPG KGNMMSNFFG
     KAAMNKFKVN LDSEQAVKEE KIVEQPTVSV TEPKLATPAG LKKSSKKAEP VKVLQKEKKR
     GKRVALSDDE TKETENMRKK RRRIKLPESD SSEDEVFPDS PGAYEAESPS PPPPPSPPLE
     PVPKTEPEPP SVKSSSGENK RKRKRVLKSK TYLDGEGCIV TEKVYESESC TDSEEELNMK
     TSSVHRPPAM TVKKEPREER KGPKKGTAAL GKANRQVSIT GFFQRK
//

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